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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
52432
World Ranking
2905
National Ranking
54

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Saverio Minucci is affiliated with the European Institute of Oncology in Italy. Their research primarily spans the disciplines of biochemistry, genetics, and molecular biology, with a significant focus on medicine. Within these fields, their work delves deeply into several subfields, including molecular biology, oncology, cancer research, immunology, and hematology.

The scientist's research topics cover a wide range of areas related to cancer biology and treatment mechanisms. These topics include epigenetics and DNA methylation, histone deacetylase inhibitors research, acute myeloid leukemia research, cancer genomics and diagnostics, single-cell and spatial transcriptomics, metabolism related to diabetes and cancer, and protein degradation and inhibitors.

Saverio Minucci has published extensively, with notable recent papers including:

  • Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin, 2021, Blood
  • Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation, 2020, Science Advances
  • Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion, 2021, Clinical Cancer Research
  • Sex and cancer immunotherapy: Current understanding and challenges, 2022, Cancer Cell
  • Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib, 2020, Journal of Medicinal Chemistry

Their work has been published frequently in several venues. The main publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Clinical Cancer Research
  • Journal of Experimental & Clinical Cancer Research

Collaborative research is a significant aspect of Saverio Minucci's output. Frequent co-authors include:

  • Elena Ceccacci
  • Isabella Pallavicini
  • Riccardo Cazzoli
  • Roberto Ravasio
  • Tiziana Bonaldi

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

    Saverio Minucci;Saverio Minucci;Pier Giuseppe Pelicci;Pier Giuseppe Pelicci

  • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

    Martin Göttlicher;Saverio Minucci;Ping Zhu;Oliver H. Krämer

  • The tripartite motif family identifies cell compartments.

    Alexandre Reymond;Germana Meroni;Anna Fantozzi;Giuseppe Merla

  • Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

    Marco Giorgio;Enrica Migliaccio;Francesca Orsini;Demis Paolucci

  • Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.

    F Grignani;S De Matteis;Clara Nervi;L Tomassoni

  • Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

    Emma Langley;Mark Pearson;Mark Pearson;Mario Faretta;Uta Maria Bauer

  • PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

    Mark Pearson;Roberta Carbone;Carla Sebastiani;Mario Cioce

  • Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor

    Luciano Di Croce;Veronica A. Raker;Massimo Corsaro;Francesco Fazi

  • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

    Adrian P. Bracken;Daniela Kleine-Kohlbrecher;Nikolaj Dietrich;Diego Pasini

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

    Angelo Cicalese;Giuseppina Bonizzi;Cristina E. Pasi;Mario Faretta

  • Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway.

    Alessandra Insinga;Silvia Monestiroli;Simona Ronzoni;Vania Gelmetti

  • Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO

    Vania Gelmetti;Jinsong Zhang;Mirco Fanelli;Saverio Minucci

  • Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.

    Paolo Pinton;Alessandro Rimessi;Saverio Marchi;Francesca Orsini

  • The histone acetylase PCAF is a nuclear receptor coactivator

    Jorge C G Blanco;Saverio Minucci;Jianming Lu;Xiang Jiao Yang

  • A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

    Mirella Trinei;Marco Giorgio;Angelo Cicalese;Sara Barozzi

  • HDACs link the DNA damage response, processing of double-strand breaks and autophagy

    Thomas Robert;Fabio Vanoli;Irene Chiolo;Ghadeer Shubassi

  • Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

    Raffaella Di Micco;Gabriele Sulli;Miryana Dobreva;Michalis Liontos

Frequent Co-Authors

Pier Giuseppe Pelicci
Pier Giuseppe Pelicci European Institute of Oncology
Antonello Mai
Antonello Mai Sapienza University of Rome
Peter Herrlich
Peter Herrlich Leibniz Association
Andrea Mattevi
Andrea Mattevi University of Pavia
Keiko Ozato
Keiko Ozato Eunice Kennedy Shriver National Institute of Child Health and Human Development
Giancarlo Pruneri
Giancarlo Pruneri University of Milan
Sergio Valente
Sergio Valente Sapienza University of Rome
Iros Barozzi
Iros Barozzi Medical University of Vienna
Paolo Bernardi
Paolo Bernardi University of Padua
Leonidas C. Platanias
Leonidas C. Platanias Northwestern University

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