World's Best Scientists 2026 revealed!
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Best Female Scientists
2025
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Microbiology
USA
2026

D-Index & Metrics

Best Female Scientists

D-Index
126
Citations
49380
World Ranking
425
National Ranking
254

Microbiology

D-Index
126
Citations
51317
World Ranking
100
National Ranking
50

Molecular Biology

D-Index
126
Citations
50384
World Ranking
218
National Ranking
132

Research.com Recognitions

  • 2026 - Research.com Microbiology in United States Leader Award
  • 2025 - Research.com Best Female Scientists Award
  • 2025 - Research.com Microbiology in United States Leader Award

Overview

Keiko Ozato is affiliated with the Eunice Kennedy Shriver National Institute of Child Health and Human Development in the United States. Their research spans across key areas in biochemistry, genetics, molecular biology, immunology, and microbiology, with a focus on immunology and molecular biology as predominant fields of study.

Their work addresses several interconnected topics, including:

  • Immune cells in cancer
  • Immunotherapy and immune responses
  • Epigenetics and DNA methylation
  • T-cell and B-cell immunology
  • Protein degradation and inhibitors
  • Genomics and chromatin dynamics
  • Immune responses and vaccinations

Ozato's frequent coauthors include Keita Saeki, Daisuke Kurotaki, Tomohiko Tamura, Anup Dey, and Mahesh Bachu. Collaboration with these researchers has contributed significantly to their publications.

Their work has been published widely, especially in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology
  • Frontiers in Immunology
  • UNC Libraries
  • Proceedings of the National Academy of Sciences

Selected recent papers by Keiko Ozato include:

  • "Trained immunity, tolerance, priming and differentiation: distinct immunological processes," 2020, Nature Immunology
  • "Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction," 2020, The EMBO Journal
  • "A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes," 2021, Nature Immunology
  • "TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis," 2020, Frontiers in Immunology
  • "Innate Immune Memory in Hematopoietic Stem/Progenitor Cells: Myeloid-Biased Differentiation and the Role of Interferon," 2021, Frontiers in Immunology

Best Publications

  • The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

    Moon Kyoo Jang;Kazuki Mochizuki;Meisheng Zhou;Ho-Sang Jeong

  • Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

    Zhiyuan Yang;Jasper H.N. Yik;Ruichuan Chen;Ruichuan Chen;Nanhai He

  • TRIM family proteins and their emerging roles in innate immunity

    Keiko Ozato;Dong-Mi Shin;Tsung-Hsien Chang;Herbert C. Morse

  • Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

    Hansjorg Keller;Christine Dreyer;Jeffrey Medin;Abderrahim Mahfoudi

  • A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

    M. H. Rosner;M. A. Vigano;K. Ozato;P. M. Timmons

  • Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

    K Ozato;N Mayer;D H Sachs

  • Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.

    K Ozato;D H Sachs

  • The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

    Anup Dey;Farideh Chitsaz;Asim Abbasi;Tom Misteli

  • Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.

    Thomas Holtschke;Jürgen Löhler;Yuka Kanno;Thomas Fehr

  • Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA

    Bo Huang;Xiao Dong Yang;Ming Ming Zhou;Keiko Ozato

  • Monoclonal antibodies to mouse major histocompatibility complex antigens.

    Keiko Ozato;Nanci M. Mayer;David H. Sachs

  • Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes

    Jianxin You;Jennie L Croyle;Akiko Nishimura;Keiko Ozato

  • Trained immunity, tolerance, priming and differentiation: distinct immunological processes.

    Maziar Divangahi;Peter Aaby;Shabaana A. Khader;Luis B. Barreiro

  • The histone acetylase PCAF is a nuclear receptor coactivator

    Jorge C G Blanco;Saverio Minucci;Jianming Lu;Xiang Jiao Yang

  • Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins

    Robert D. Phair;Paola Scaffidi;Cem Elbi;Jaromíra Vecerová

  • Displacement of sequence-specific transcription factors from mitotic chromatin

    Marian A. Martínez-Balbás;Anup Dey;Sridhar K. Rabindran;Keiko Ozato

  • H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

    M S Marks;P L Hallenbeck;T Nagata;J H Segars

  • IFN Regulatory Factor-4 and -8 Govern Dendritic Cell Subset Development and Their Functional Diversity

    Tomohiko Tamura;Prafullakumar Tailor;Kunihiro Yamaoka;Hee Jeong Kong

  • Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

    Hyokjoon Kwon;Danielle Thierry-Mieg;Jean Thierry-Mieg;Hyoung Pyo Kim

  • Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.

    Haixia Xu;Jimmy Zhu;Sinead Smith;Julia Foldi

  • An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

    Paul H. Driggers;David L. Ennist;Shannon L. Gleason;Wai-Han Mak

Frequent Co-Authors

Tomohiko Tamura
Tomohiko Tamura Yokohama City University
Herbert C. Morse
Herbert C. Morse National Institute of Allergy and Infectious Diseases
Akira Nishiyama
Akira Nishiyama Kagawa University
David H. Sachs
David H. Sachs Columbia University
Ettore Appella
Ettore Appella National Institutes of Health
Saverio Minucci
Saverio Minucci European Institute of Oncology
Huabao Xiong
Huabao Xiong Icahn School of Medicine at Mount Sinai
Yuka Kanno
Yuka Kanno National Institutes of Health
Kebin Liu
Kebin Liu Augusta University
Jonathan G. Seidman
Jonathan G. Seidman Harvard University

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