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Biology and Biochemistry

D-Index
52
Citations
23618
World Ranking
16426
National Ranking
6792

Overview

Franck J. Barrat is a researcher affiliated with the Hospital for Special Surgery in the United States, with a primary focus on immunology, molecular biology, and medicine. Their research spans several interconnected fields, including immunology and microbiology, biochemistry, genetics, and molecular biology.

The main topics of Barrat's work cover a wide range of immune-related processes and disorders. These include:

  • Immunotherapy and Immune Responses
  • Interferon and Immune Responses
  • Immune Response and Inflammation
  • T-cell and B-cell Immunology
  • Inflammasome and Immune Disorders
  • Immune Cell Function and Interaction
  • Systemic Sclerosis and Related Diseases

Barrat has contributed to studies published across multiple prominent journals. Frequent venues for their publications are:

  • The Journal of Experimental Medicine
  • The Journal of Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunological Reviews
  • Research Square (Research Square)

Recent notable papers include:

  • "Epigenetic memory of coronavirus infection in innate immune cells and their progenitors," 2023, Cell
  • "Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19," 2022, Science Immunology
  • "Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer," 2022, Cancer Discovery
  • "Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses," 2022, The Journal of Experimental Medicine
  • "Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation," 2022, The Journal of Experimental Medicine

Frequent co-authors in Barrat's work include:

  • Marie Dominique Ah Kioon
  • Lionel B. Ivashkiv
  • Yong Du
  • Chao Yang
  • Paôline Laurent

Best Publications

  • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

    Lionel Apetoh;François Ghiringhelli;Antoine Tesniere;Antoine Tesniere;Antoine Tesniere;Michel Obeid;Michel Obeid;Michel Obeid

  • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

    Franck J. Barrat;Daniel J. Cua;André Boonstra;David F. Richards

  • Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

    Gina S. Garcia-Romo;Simone Caielli;Barbara Vega;John Connolly

  • 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.

    André Boonstra;Franck J. Barrat;Chad Crain;Victoria L. Heath

  • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

    Franck J. Barrat;Thea Meeker;Josh Gregorio;Jean H. Chan

  • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

    Holger Kanzler;Franck J Barrat;Edith M Hessel;Robert L Coffman

  • IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells

    Pedro L. Vieira;Jillian R. Christensen;Sophie Minaee;Emma J. O’Neill

  • Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

    Dipyaman Ganguly;Georgios Chamilos;Roberto Lande;Josh Gregorio;Josh Gregorio

  • Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.

    Emmanuel Xystrakis;Siddharth Kusumakar;Sandra Boswell;Emma Peek

  • Strategies for use of IL‐10 or its antagonists in human disease

    Anne O'Garra;Franck J. Barrat;Antonio G. Castro;Alain Vicari

  • Interferon target-gene expression and epigenomic signatures in health and disease

    Franck J. Barrat;Mary K. Crow;Mary K. Crow;Lionel B. Ivashkiv;Lionel B. Ivashkiv

  • Griscelli Disease Maps to Chromosome 15q21 and Is Associated With Mutations in the myosin-Va Gene

    Pastural E;Barrat Fj;Dufourcq-Lagelouse R;Certain S

  • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

    Cristiana Guiducci;Gary Ott;Jean H. Chan;Emily Damon

  • Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

    Julien Diana;Julien Diana;Yannick Simoni;Yannick Simoni;Laetitia Furio;Laetitia Furio;Lucie Beaudoin;Lucie Beaudoin

  • Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

    Cheng Lung Ku;Horst Von Bernuth;Horst Von Bernuth;Capucine Picard;Shen Ying Zhang

  • Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

    Judith N Mandl;Ashley P Barry;Thomas H Vanderford;Natalia Kozyr

  • TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

    Cristiana Guiducci;Mei Gong;Zhaohui Xu;Michelle Gill

  • Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms.

    Franck J. Barrat;Thea Meeker;Jean H. Chan;Cristiana Guiducci

  • Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses

    Kun Yang;Kun Yang;Anne Puel;Shenying Zhang;Shenying Zhang;Céline Eidenschenk

  • TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

    Rafaz Hoque;Muhammad Sohail;Ahsan Malik;Sherhayar Sarwar

Frequent Co-Authors

Robert L. Coffman
Robert L. Coffman University of California, Santa Cruz
Anne O'Garra
Anne O'Garra The Francis Crick Institute
Virginia Pascual
Virginia Pascual Cornell University
Anne-Marie Fischer
Anne-Marie Fischer Université Paris Cité
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Alain Fischer
Alain Fischer Collège de France
Vassili Soumelis
Vassili Soumelis Université Paris Cité
Alfredo Criollo
Alfredo Criollo University of Chile
Carl Nathan
Carl Nathan Cornell University
Capucine Picard
Capucine Picard Université Paris Cité

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