World's Best Scientists 2026 revealed!

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Immunology

D-Index
103
Citations
66926
World Ranking
628
National Ranking
366

Medicine

D-Index
103
Citations
66937
World Ranking
7170
National Ranking
3765

Overview

Robert L. Coffman is affiliated with Schering-Plough in the United States and specializes in research primarily within the fields of Medicine and Immunology and Microbiology. Their work emphasizes subfields such as Immunology, Infectious Diseases, Epidemiology, Oncology, and Pulmonary and Respiratory Medicine.

The scientist's research focuses on key topics including SARS-CoV-2 and COVID-19 research, immunotherapy and immune responses, respiratory viral infections research, COVID-19 clinical research studies, immune response and inflammation, IL-33, ST2, and ILC pathways, as well as cancer immunotherapy and biomarkers.

Among the recent publications authored or co-authored by Robert L. Coffman are:

  • Adjuvanting a subunit COVID-19 vaccine to induce protective immunity, 2021, Nature
  • Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19, 2020, Scientific Reports
  • Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice, 2022, npj Vaccines
  • A Phase 2a, Double-Blind, Placebo-controlled Randomized Trial of Inhaled TLR9 Agonist AZD1419 in Asthma, 2020, American Journal of Respiratory and Critical Care Medicine
  • A CpG 1018 adjuvanted neuraminidase vaccine provides robust protection from influenza virus challenge in mice, 2022, npj Vaccines

The scientist frequently collaborates with other researchers, including Prabhu S. Arunachalam, Alexandra C. Walls, Lilin Lai, Samuel Wrenn, and Deleah Pettie. Their repeated collaborations indicate ongoing research partnerships in related areas of study.

Robert L. Coffman's work has been published multiple times in venues such as npj Vaccines, bioRxiv (Cold Spring Harbor Laboratory), Clinical Cancer Research, Nature, and Scientific Reports. These publications suggest an engagement with both peer-reviewed journals and preprint platforms.

Best Publications

  • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

    Timothy R Mosmann;Holly Cherwinski;Martha W Bond;Martin A Giedlin

  • Vaccine Adjuvants: Putting Innate Immunity to Work

    Robert L. Coffman;Alan Sher;Robert A. Seder

  • An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

    Chrystelle Asseman;Smita Mauze;Michael W. Leach;Robert L. Coffman

  • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.

    Fiona Powrie;Michael W. Leach;Smita Mauze;Satish Menon

  • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

    Franck J. Barrat;Daniel J. Cua;André Boonstra;David F. Richards

  • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

    F Powrie;M W Leach;S Mauze;L B Caddle

  • Lymphokine control of in vivo immunoglobulin isotype selection.

    Finkelman Fd;Holmes J;Katona Im;Urban Jf

  • Heterogeneity of cytokine secretion patterns and functions of helper T cells.

    Tim R. Mosmann;Robert L. Coffman

  • Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

    Gina S. Garcia-Romo;Simone Caielli;Barbara Vega;John Connolly

  • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

    Franck J. Barrat;Thea Meeker;Josh Gregorio;Jean H. Chan

  • A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

    F Powrie;J Carlino;M W Leach;S Mauze

  • Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

    and A Sher;R L Coffman

  • Two types of mouse helper T-cell clone Implications for immune regulation.

    Tim R. Mosmann;Robert L. Coffman

  • Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells.

    Tracy L. Stevens;Alexis Bossie;Virginia M. Sanders;Rafael Fernandez-Botran

  • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

    Holger Kanzler;Franck J Barrat;Edith M Hessel;Robert L Coffman

  • B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

    R L Coffman;J Ohara;M W Bond;J Carty

  • Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

    P Scott;P Natovitz;R L Coffman;E Pearce

  • The role of helper T cell products in mouse B cell differentiation and isotype regulation.

    Robert L. Coffman;Brian W. P. Seymour;Deborah A. Lebman;Debra D. Hiraki

  • New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25

    Stephen D. Hurst;Tony Muchamuel;Daniel M. Gorman;Jonathan M. Gilbert

  • Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice.

    Robert L. Coffman;Brian W. P. Seymour;Susan Hudak;John Jackson

Frequent Co-Authors

Franck J. Barrat
Franck J. Barrat Hospital for Special Surgery
Tim R. Mosmann
Tim R. Mosmann University of Rochester Medical Center
Jonathan W. Friedberg
Jonathan W. Friedberg University of Rochester
Fiona Powrie
Fiona Powrie University of Oxford
Virginia Pascual
Virginia Pascual Cornell University
Viswanath P. Kurup
Viswanath P. Kurup Medical College of Wisconsin
Arnold S. Freedman
Arnold S. Freedman Harvard University
Robert A. Kastelein
Robert A. Kastelein MSD (United States)
Paul B. Rothman
Paul B. Rothman Johns Hopkins University School of Medicine
Anne O'Garra
Anne O'Garra The Francis Crick Institute

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