Robert A. Kastelein

Overview

Best Publications

• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  Claire L. Langrish;Yi Yi Chen;Wendy M Blumenschein;Jeanine D. Mattson

  5391
  Citations

• IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

  Jochen Schmitz;Alexander Owyang;Elizabeth Oldham;Yaoli Song

  4484
  Citations

• Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

  Daniel J. Cua;Jonathan Sherlock;Yi Chen;Craig A. Murphy

  3743
  Citations

• Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

  Birgit Oppmann;Robin Lesley;Bianca Blom;Jackie C. Timans

  3712
  Citations

• Development, cytokine profile and function of human interleukin 17-producing helper T cells

  Nicholas J Wilson;Katia Boniface;Jason R Chan;Brent S McKenzie

  2621
  Citations

• Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

  Vassili Soumelis;Pedro A Reche;Holger Kanzler;Wei Yuan

  2614
  Citations

• Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

  Norimitsu Kadowaki;Stephen Ho;Svetlana Antonenko;Rene de Waal Malefyt

  2570
  Citations

• A family of human receptors structurally related to Drosophila Toll

  F L Rock;G Hardiman;J C Timans;R A Kastelein

  2503
  Citations

• Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

  Craig A. Murphy;Claire L. Langrish;Yi Yi Chen;Wendy M Blumenschein

  2175
  Citations

• Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

  R de Waal Malefyt;J Haanen;H Spits;M G Roncarolo

  2091
  Citations

• IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

  David Yen;Jeanne Cheung;Heleen Scheerens;Frédérique Poulet

  2007
  Citations

• IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

  Stefan Pflanz;Jackie C Timans;Jeanne Cheung;Rency Rosales

  1895
  Citations

• A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

  Christi Parham;Madaline Chirica;Jacqueline Timans;Elena Vaisberg

  1715
  Citations

• IL-23 promotes tumour incidence and growth

  John L. Langowski;Xueqing Zhang;Lingling Wu;Jeanine D. Mattson

  1254
  Citations

• The IL-12 Family of Heterodimeric Cytokines: New Players in the Regulation of T Cell Responses

  Giorgio Trinchieri;Stefan Pflanz;Robert A Kastelein

  1251
  Citations

• Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

  Frank A. W. Verreck;Tjitske de Boer;Dennis M. L. Langenberg;Marieke A. Hoeve

  1229
  Citations

• IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells

  Jonathan P Sherlock;Barbara Joyce-Shaikh;Scott P Turner;Cheng-Chi Chao

  1213
  Citations

• Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

  P Vieira;R de Waal-Malefyt;M N Dang;K E Johnson

  1165
  Citations

• Understanding the IL-23–IL-17 immune pathway

  Brent S. McKenzie;Robert A. Kastelein;Daniel J. Cua

  1067
  Citations

• Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation

  Robert A. Kastelein;Christopher A. Hunter;Daniel J. Cua

  964
  Citations