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Biology and Biochemistry

D-Index
51
Citations
10719
World Ranking
17078
National Ranking
1178

Overview

Ralf Baumeister is affiliated with the University of Freiburg in Germany. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant emphasis on molecular biology, aging, physiology, genetics, and cell biology as subfields. Their work spans several interconnected topics including genetics, aging, and longevity in model organisms, physiological and biochemical adaptations, evolution and genetic dynamics, PI3K/AKT/mTOR signaling in cancer, microtubule and mitosis dynamics, adipose tissue and metabolism, and mitochondrial function and pathology.

Baumeister's publication record includes contributions to high-impact journals and frequent appearances in venues such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Science, Cell, and Cells. Notable recent papers include:

  • "Neutrophils self-limit swarming to contain bacterial growth in vivo," 2021, Science
  • "G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling," 2021, Cell
  • "Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold," 2023, Cells
  • "Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation," 2024, Immunity
  • "TORC2-SGK-1 signaling integrates external signals to regulate autophagic turnover of mitochondria via mtROS," 2020, Autophagy

The scientist frequently collaborates with other researchers, with common coauthors including Wenjing Qi, Thomas Heimbucher, Fan Xu, Erika D. von Gromoff, and Bettina Warscheid. These collaborations often contribute to the breadth and depth of their investigations into molecular and cellular mechanisms.

Their work covers a range of biological processes with a special focus on complex signaling pathways and metabolic adaptations at the cellular level, especially relating to aging and longevity. The focus on PI3K/AKT/mTOR signaling highlights an intersection with cancer biology, while studies on mitochondrial function and apoptosis contribute to understanding cellular homeostasis and immune responses.

Best Publications

  • Perception of UV-B by the arabidopsis UVR8 protein

    Luca Rizzini;Jean Jacques Favory;Catherine Cloix;Davide Faggionato

  • Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

    Jennifer M. A. Tullet;Maren Hertweck;Jae Hyung An;Jae Hyung An;Joseph Baker

  • C. elegans SGK-1 Is the Critical Component in the Akt/PKB Kinase Complex to Control Stress Response and Life Span

    Maren Hertweck;Christine Göbel;Ralf Baumeister;Ralf Baumeister

  • A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

    Harald Steiner;Karen Duff;Anja Capell;Helmut Romig

  • Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

    Harald Steiner;Marcus Kostka;Helmut Romig;Gabriele Basset

  • Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

    Kathrin Thedieck;Birgit Holzwarth;Mirja Tamara Prentzell;Christopher Boehlke

  • Thermal avoidance in Caenorhabditis elegans: an approach to the study of nociception.

    Nicole Wittenburg;Ralf Baumeister

  • Endocrine signaling in Caenorhabditis elegans controls stress response and longevity.

    Ralf Baumeister;Elke Schaffitzel;Maren Hertweck

  • C. elegans metallothioneins: new insights into the phenotypic effects of cadmium toxicosis

    S C Swain;K Keusekotten;R Baumeister;Stephen Sturzenbaum

  • Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

    Eva D. Runkel;Shu Liu;Ralf Baumeister;Ekkehard Schulze

  • Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch

    Anja Capell;Harald Steiner;Helmut Romig;Simone Keck

  • Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth.

    Julia Sämann;Jan Hegermann;Erika von Gromoff;Stefan Eimer

  • Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.

    Barbara Meissner;Barbara Meissner;Michael Boll;Hannelore Daniel;Ralf Baumeister;Ralf Baumeister

  • Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

    Chronis Fatouros;Ghulam Jeelani Pir;Jacek Biernat;Sandhya Padmanabhan Koushika

  • The Biological and Pathological Function of the Presenilin-1 ΔExon 9 Mutation Is Independent of Its Defect to Undergo Proteolytic Processing

    Harald Steiner;Helmut Romig;Melissa G. Grim;Uwe Philipp

  • Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis

    Tim O Lankisch;Jochen Metzger;Ahmed A Negm;Katja Vosskuhl

  • A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation

    Piero Dalle Pezze;Annika G Sonntag;Antje Thien;Mirja T Prentzell

  • Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.

    Thorsten Hoppe;Thorsten Hoppe;Giuseppe Cassata;José M. Barral;Wolfdieter Springer

  • A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.

    Assunta Croce;Giuseppe Cassata;Andrea Disanza;Maria Cristina Gagliani

  • Presenilin is required for proper morphology and function of neurons in C. elegans.

    Nicole Wittenburg;Stefan Eimer;Bernard Lakowski;Sascha Röhrig

Frequent Co-Authors

Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Harald Steiner
Harald Steiner Ludwig-Maximilians-Universität München
Anja Capell
Anja Capell Ludwig-Maximilians-Universität München
Michael Reth
Michael Reth University of Freiburg
John Hardy
John Hardy University College London
Aurelio A. Teleman
Aurelio A. Teleman German Cancer Research Center
Jacek Gaertig
Jacek Gaertig University of Georgia
Elisabeth Kremmer
Elisabeth Kremmer Max Planck Society
Roland Nitschke
Roland Nitschke University of Freiburg
Dietmar Pfeifer
Dietmar Pfeifer University of Freiburg

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