Harald Steiner

Overview

Best Publications

• Reconstitution of gamma-secretase activity.

  Dieter Edbauer;Edith Winkler;Joerg T. Regula;Brigitte Pesold

  1327
  Citations

• Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

  Magdalena Sastre;Harald Steiner;Klaus Fuchs;Anja Capell

  643
  Citations

• A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

  Andrea Geling;Harald Steiner;Michael Willem;Laure Bally‐Cuif

  637
  Citations

• PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin

  Harald Steiner;Edith Winkler;Dieter Edbauer;Stefan Prokop

  411
  Citations

• Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42 *

  Christine Wild-Bode;Tsuneo Yamazaki;Anja Capell;Uwe Leimer

  410
  Citations

• A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

  Harald Steiner;Karen Duff;Anja Capell;Helmut Romig

  402
  Citations

• Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

  Sven Lammich;Masayasu Okochi;Masatoshi Takeda;Christoph Kaether

  385
  Citations

• Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

  Harald Steiner;Marcus Kostka;Helmut Romig;Gabriele Basset

  382
  Citations

• Maturation and Pro-peptide Cleavage of β-Secretase

  Anja Capell;Harald Steiner;Michael Willem;Hartmut Kaiser

  367
  Citations

• Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation

  Dieter Edbauer;Edith Winkler;Christian Haass;Harald Steiner

  342
  Citations

• Presenilins mediate a dual intramembranous γ‐secretase cleavage of Notch‐1

  Masayasu Okochi;Harald Steiner;Akio Fukumori;Hisashi Tanii

  330
  Citations

• Regulated intramembrane proteolysis – lessons from amyloid precursor protein processing

  Stefan F. Lichtenthaler;Christian Haass;Harald Steiner

  323
  Citations

• Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production

  Tobias Moehlmann;Edith Winkler;Xuefeng Xia;Dieter Edbauer

  321
  Citations

• An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

  Kai Schlepckow;Gernot Kleinberger;Akio Fukumori;Regina Feederle

  308
  Citations

• Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

  Alessio Vittorio Colombo;Rebecca Katie Sadler;Gemma Llovera;Vikramjeet Singh

  301
  Citations

• Intramembrane Proteolysis by γ-Secretase

  Harald Steiner;Regina Fluhrer;Christian Haass

  299
  Citations

• Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation

  Harald Steiner;Anja Capell;Brigitte Pesold;Martin Citron

  291
  Citations

• Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)

  Dieter Edbauer;Michael Willem;Sven Lammich;Harald Steiner

  289
  Citations

• The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.

  J. Wieland;A. M. Nitsche;J. Strayle;H. Steiner

  272
  Citations

• Identification of distinct γ-secretase complexes with different APH-1 variants

  Keiro Shirotani;Dieter Edbauer;Stefan Prokop;Christian Haass

  257
  Citations

• Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases

  Christian Haass;Harald Steiner

  251
  Citations

• Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

  Christoph Kaether;Sven Lammich;Dieter Edbauer;Michaela Ertl

  249
  Citations