D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 57 Citations 11,333 119 World Ranking 7630 National Ranking 591
Biology and Biochemistry D-index 67 Citations 15,122 149 World Ranking 5258 National Ranking 374

Overview

What is he best known for?

The fields of study Harald Steiner is best known for:

  • Gene
  • Enzyme
  • Amino acid

When carried out as part of a general Component (thermodynamics) research project, his work on Thermodynamics is frequently linked to work in Computational biology, therefore connecting diverse disciplines of study. He combines Thermodynamics and Component (thermodynamics) in his studies. He incorporates Computational biology and Biochemistry in his studies. Harald Steiner combines Biochemistry and Inorganic chemistry in his research. His Inorganic chemistry study frequently draws connections between related disciplines such as Amyloid (mycology). Alzheimer's disease and Proteolysis are two areas of study in which he engages in interdisciplinary work. Harald Steiner integrates Proteolysis with Alzheimer's disease in his study. As part of his studies on Disease, he often connects relevant subjects like BACE1-AS. Harald Steiner undertakes multidisciplinary studies into BACE1-AS and Amyloid precursor protein in his work.

His most cited work include:

  • Reconstitution of γ-secretase activity (828 citations)
  • Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch (456 citations)
  • A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling (296 citations)

What are the main themes of his work throughout his whole career to date

In his works, Harald Steiner conducts interdisciplinary research on Biochemistry and Biophysics. Harald Steiner performs multidisciplinary study on Biophysics and Biochemistry in his works. Many of his studies on Disease apply to Internal medicine as well. His research ties Disease and Internal medicine together. Harald Steiner integrates many fields, such as Alzheimer's disease and Proteolysis, in his works. He integrates Proteolysis and Alzheimer's disease in his studies. He conducted interdisciplinary study in his works that combined Cell biology and Enzyme. Harald Steiner undertakes interdisciplinary study in the fields of Enzyme and Protease through his works. He incorporates Presenilin and Alpha secretase in his studies.

Harald Steiner most often published in these fields:

  • Biochemistry (76.99%)
  • Disease (66.37%)
  • Alzheimer's disease (64.60%)

What were the highlights of his more recent work (between 2018-2022)?

  • Biochemistry (66.67%)
  • Disease (46.67%)
  • Cell biology (40.00%)

In recent works Harald Steiner was focusing on the following fields of study:

As part of his inquiry into Mutation and Protein subunit, Harald Steiner is doing Gene research. Harald Steiner applies his multidisciplinary studies on Mutation and Gene in his research. Harald Steiner is investigating Proteases and Proteolysis as part of his examination of Enzyme. Harald Steiner performs integrative Biochemistry and Organic chemistry research in his work. Harald Steiner performs multidisciplinary study in Organic chemistry and Biochemistry in his work. Disease and Pathology are two areas of study in which Harald Steiner engages in interdisciplinary research. As part of his studies on Pathology, Harald Steiner often connects relevant areas like Alzheimer's disease. He connects Alzheimer's disease with Alpha secretase in his research. His Disease research extends to the thematically linked field of Alpha secretase.

Between 2018 and 2022, his most popular works were:

  • Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition (92 citations)
  • Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease (28 citations)
  • Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage (28 citations)

In his most recent research, the most cited works focused on:

  • Gene
  • Enzyme
  • Amino acid

A component of his Enzyme study involves Proteases and Proteolysis. He undertakes multidisciplinary studies into Proteases and Enzyme in his work. Biochemistry and Biophysics are two areas of study in which Harald Steiner engages in interdisciplinary work. In his works, he performs multidisciplinary study on Biophysics and Biochemistry. His work on Ectodomain expands to the thematically related Receptor. Harald Steiner merges Ectodomain with Signal transduction in his research. Harald Steiner performs integrative Signal transduction and Receptor research in his work. Harald Steiner performs integrative Transmembrane protein and Transmembrane domain research in his work. Harald Steiner conducted interdisciplinary study in his works that combined Transmembrane domain and C-terminus.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Reconstitution of gamma-secretase activity.

Dieter Edbauer;Edith Winkler;Joerg T. Regula;Brigitte Pesold.
Nature Cell Biology (2003)

1284 Citations

Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

Magdalena Sastre;Harald Steiner;Klaus Fuchs;Anja Capell.
EMBO Reports (2001)

625 Citations

A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

Andrea Geling;Harald Steiner;Michael Willem;Laure Bally‐Cuif.
EMBO Reports (2002)

600 Citations

PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin

Harald Steiner;Edith Winkler;Dieter Edbauer;Stefan Prokop.
Journal of Biological Chemistry (2002)

398 Citations

Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42 *

Christine Wild-Bode;Tsuneo Yamazaki;Anja Capell;Uwe Leimer.
Journal of Biological Chemistry (1997)

397 Citations

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

Harald Steiner;Karen Duff;Anja Capell;Helmut Romig.
Journal of Biological Chemistry (1999)

389 Citations

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

Harald Steiner;Marcus Kostka;Helmut Romig;Gabriele Basset.
Nature Cell Biology (2000)

374 Citations

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Sven Lammich;Masayasu Okochi;Masatoshi Takeda;Christoph Kaether.
Journal of Biological Chemistry (2002)

365 Citations

Maturation and Pro-peptide Cleavage of β-Secretase

Anja Capell;Harald Steiner;Michael Willem;Hartmut Kaiser.
Journal of Biological Chemistry (2000)

360 Citations

Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation

Dieter Edbauer;Edith Winkler;Christian Haass;Harald Steiner.
Proceedings of the National Academy of Sciences of the United States of America (2002)

325 Citations

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