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Biology and Biochemistry

D-Index
49
Citations
9338
World Ranking
17987
National Ranking
1236

Overview

Dieter Langosch is affiliated with the Technical University of Munich in Germany and has a body of research primarily situated within Biochemistry, Genetics, and Molecular Biology. Their work has contributed to various subfields including Molecular Biology, Cell Biology, Physiology, Cellular and Molecular Neuroscience, and Biophysics.

The researcher's main topics of focus encompass cellular transport and secretion, protein structure and dynamics, Alzheimer's disease research and treatments, lipid membrane structure and behavior, photoreceptor and optogenetics research, photosynthetic processes and mechanisms, and advanced fluorescence microscopy techniques.

Some of the recent papers authored or coauthored by Langosch include:

  • Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion (2020) in Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix (2020) in iScience
  • Determining the Stoichiometry of Small Protein Oligomers Using Steady-State Fluorescence Anisotropy (2020) in Biophysical Journal
  • Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity (2022) in EMBO Molecular Medicine
  • Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces (2020) in Computational and Structural Biotechnology Journal

Langosch has published multiple papers in a variety of scientific venues, notably:

  • Biophysical Journal
  • Scientific Reports
  • Biochimica et Biophysica Acta (BBA) - Biomembranes
  • iScience
  • EMBO Molecular Medicine

Coauthors frequently collaborating with Langosch include Walter Stelzer, Harald Steiner, Stefan F. Lichtenthaler, Claudia Muhle-Goll, and Gökhan Güner.

Best Publications

  • Identification of a gephyrin binding motif on the glycine receptor β subunit

    Guido Meyer;Joachim Kirsch;Heinrich Betz;Dieter Langosch

  • Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

    Dieter Langosch;Leo Thomas;Heinrich Betz

  • The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

    I. Pribilla;T. Takagi;D. Langosch;J. Bormann

  • Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane.

    Leo Thomas;Klaus Hartung;Dieter Langosch;Hubert Rehm

  • Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein

    P. Prior;B. Schmitt;G. Grenningloh;I. Pribilla

  • GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

    Lisa-Marie Munter;Philipp Voigt;Anja Harmeier;Daniela Kaden

  • The 93-kDa glycine receptor-associated protein binds to tubulin.

    J. Kirsch;D. Langosch;P. Prior;U.Z. Littauer

  • Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers.

    J Bormann;N Rundström;H Betz;D Langosch

  • Dimerisation of the Glycophorin A Transmembrane Segment in Membranes Probed with the ToxR Transcription Activator

    Dieter Langosch;Bettina Brosig;Harald Kolmar;Hans-Joachim Fritz

  • The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues.

    Bettina Brosig;Dieter Langosch

  • A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments.

    Rolf Gurezka;Rico Laage;Bettina Brosig;Dieter Langosch

  • The inhibitory glycine receptor: a ligand-gated chloride channel of the central nervous system.

    Dieter Langosch;Cord‐Michael Becker;Heinrich Betz

  • Role of GxxxG Motifs in Transmembrane Domain Interactions

    Mark G. Teese;Mark G. Teese;Dieter Langosch;Dieter Langosch

  • Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing

    Christian Ungermann;Dieter Langosch

  • Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.

    D. Langosch;Bodo Laube;N. Rundström;V. Schmieden

  • Interaction of transmembrane helices by a knobs‐into‐holes packing characteristic of soluble coiled coils

    Dieter Langosch;Jaap Heringa

  • Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity.

    Dieter Langosch;Jonathan M Crane;Bettina Brosig;Andrea Hellwig

  • Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

    Katharina F. Kubatzky;Weiming Ruan;Rolf Gurezka;Jacob Cohen

  • Interaction and conformational dynamics of membrane-spanning protein helices

    Dieter Langosch;Isaiah T. Arkin

  • Decreased agonist affinity andchloride conductance ofmutantglycine receptors associated withhuman hereditary hyperekplexia

    Dieter Langosch;Volker Schmieden

Frequent Co-Authors

Heinrich Betz
Heinrich Betz Max Planck Society
Gerd Multhaup
Gerd Multhaup McGill University
Daniel Huster
Daniel Huster Leipzig University
Harald Steiner
Harald Steiner Ludwig-Maximilians-Universität München
Burkhard Luy
Burkhard Luy Karlsruhe Institute of Technology
Dmitrij Frishman
Dmitrij Frishman Technical University of Munich
Christian Ungermann
Christian Ungermann Osnabrück University
Huub J. M. de Groot
Huub J. M. de Groot Leiden University
Cord-Michael Becker
Cord-Michael Becker University of Erlangen-Nuremberg
Ursula Klingmüller
Ursula Klingmüller German Cancer Research Center

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