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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
12941
World Ranking
13112
National Ranking
933

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Ursula Klingmüller is a researcher affiliated with the German Cancer Research Center in Germany. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Molecular Biology, Immunology, Hepatology, Pulmonary and Respiratory Medicine, and Epidemiology.

The main topics covered by their research include:

  • Liver Disease Diagnosis and Treatment
  • Liver physiology and pathology
  • Metabolomics and Mass Spectrometry Studies
  • Cytokine Signaling Pathways and Interactions
  • Advanced Proteomics Techniques and Applications
  • Interferon and immune responses
  • Lung Cancer Treatments and Mutations

Klingmüller has contributed to multiple papers in well-recognized venues. Recent publications include:

  • mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability, 2020, Nature Communications
  • Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice, 2020, Nature Communications
  • Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis, 2020, Proceedings of the National Academy of Sciences
  • Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction, 2020, Molecular Systems Biology
  • Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production, 2021, Frontiers in Immunology

Frequent coauthors who have collaborated extensively with Klingmüller are:

  • Barbara Helm
  • Marcel Schilling
  • Lorenza A. D'Alessandro
  • Jan G. Hengstler
  • Thomas Muley

Research output is distributed across several publication venues with the most frequent venues being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zeitschrift für Gastroenterologie
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Molecular Systems Biology

Klingmüller is recognized as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

    A. Raue;C. Kreutz;T. Maiwald;J. Bachmann

  • SPECIFIC RECRUITMENT OF SH-PTP1 TO THE ERYTHROPOIETIN RECEPTOR CAUSES INACTIVATION OF JAK2 AND TERMINATION OF PROLIFERATIVE SIGNALS

    Ursula Klingmüller;Ursula Klingmüller;Ulrike Lorenz;Lewis C Cantley;Benjamin G Neel

  • Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling

    I. Swameye;I. Swameye;T. G. Müller;J. Timmer;O. Sandra;O. Sandra

  • Lessons learned from quantitative dynamical modeling in systems biology.

    Andreas Raue;Marcel Schilling;Julie Bachmann;Andrew Matteson

  • Interaction of the erythropoietin and stem-cell-factor receptors

    Hong Wu;Ursula Klingmüller;Peter Besmer;Harvey F. Lodish

  • The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

    Mirco Castoldi;Maja Vujic Spasic;Sandro Altamura;Joacim Elmén

  • CYTOKINE RECEPTOR SIGNAL TRANSDUCTION AND THE CONTROL OF HEMATOPOIETIC CELL DEVELOPMENT

    Stephanie S. Watowich;Hong Wu;Merav Socolovsky;Ursula Klingmuller

  • Data2Dynamics: A modeling environment tailored to parameter estimation in dynamical systems

    A. Raue;B. Steiert;M. Schelker;C. Kreutz

  • Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains

    Dehua Pei;Ulrike Lorenz;Ulrike Lorenz;Ursula Klingmuller;Benjamin G. Neel;Benjamin G. Neel

  • Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

    Ursula Klingmüller;Svetlana Bergelson;Jonathan G. Hsiao;Harvey F. Lodish

  • Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

    Richard J Weaver;Eric A Blomme;Amy E Chadwick;Ian M Copple

  • Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

    Ursula Klingmüller;Hong Wu;Hong Wu;Jonathan G. Hsiao;Jonathan G. Hsiao;Alex Toker

  • Addressing parameter identifiability by model-based experimentation

    A. Raue;C. Kreutz;T. Maiwald;U. Klingmuller

  • Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

    Hong Wu;Ursula Klingmüller;Adriana Acurio;Jonathan G. Hsiao;Jonathan G. Hsiao

  • Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor

    Verena Becker;Verena Becker;Marcel Schilling;Julie Bachmann;Ute Baumann

  • Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor.

    Ursula Klingmüller;Heinz Schaller

  • Simulation Methods for Optimal Experimental Design in Systems Biology

    Daniel Faller;Ursula Klingmüller;Jens Timmer

  • Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1

    Marcin Kortylewski;Peter C. Heinrich;Andrzej Mackiewicz;Ute Schniertshauer

  • A mouse model for visualization and conditional mutations in the erythroid lineage

    Achim C. Heinrich;Roberta Pelanda;Ursula Klingmüller

  • The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.

    Ulrike Lemke;Anja Krones-Herzig;Mauricio Berriel Diaz;Prachiti Narvekar

Frequent Co-Authors

Fabian J. Theis
Fabian J. Theis Technical University of Munich
Hong Wu
Hong Wu Peking University
Norbert Gretz
Norbert Gretz Heidelberg University
Thomas Höfer
Thomas Höfer German Cancer Research Center
Jan G. Hengstler
Jan G. Hengstler TU Dortmund University
Bob van de Water
Bob van de Water Leiden University
Stephanie S. Watowich
Stephanie S. Watowich The University of Texas MD Anderson Cancer Center
Benjamin G. Neel
Benjamin G. Neel New York University Langone Medical Center
Dieter Häussinger
Dieter Häussinger Heinrich Heine University Düsseldorf

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