World's Best Scientists 2026 revealed!
Yoshihito Watanabe

Yoshihito Watanabe

D-Index & Metrics

Chemistry

D-Index
73
Citations
15418
World Ranking
5111
National Ranking
296

Overview

Yoshihito Watanabe is affiliated with Nagoya University in Japan and contributes to the fields of Chemistry and Biochemistry, Genetics and Molecular Biology. Their research spans subfields such as Molecular Biology, Inorganic Chemistry, Computational Theory and Mathematics, Pharmacology, and Spectroscopy.

The scientist's major research topics include:

  • Computational Drug Discovery Methods
  • Pharmacogenetics and Drug Metabolism
  • Metal-Catalyzed Oxygenation Mechanisms
  • Asymmetric Hydrogenation and Catalysis
  • Mass Spectrometry Techniques and Applications
  • Chemical Synthesis and Analysis
  • Analytical Chemistry and Chromatography

Their recent publications cover a range of studies involving enzyme catalysis and molecular design. Notable papers include:

  • "Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3," 2020, ACS Catalysis
  • "Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain," 2020, Angewandte Chemie International Edition
  • "Molecular Design and Regulation of Metalloenzyme Activities through Two Novel Approaches: Ferritin and P450s," 2020, Bulletin of the Chemical Society of Japan
  • "Enhanced cis- and enantioselective cyclopropanation of styrene catalysed by cytochrome P450BM3 using decoy molecules," 2020, Chemical Communications
  • "Exploring hitherto uninvestigated reactions of the fatty acid peroxygenase CYP152A1: catalase reaction and Compound I formation," 2021, Faraday Discussions

Frequent publication venues for Yoshihito Watanabe's work include:

  • ACS Catalysis
  • Angewandte Chemie International Edition
  • Bulletin of the Chemical Society of Japan
  • Chemical Communications
  • Faraday Discussions

The scientist collaborates regularly with a defined group of co-authors, including:

  • Osami Shoji
  • Joshua Kyle Stanfield
  • Chie Kasai
  • Hiroshi Sugimoto
  • Shinya Ariyasu

Best Publications

  • Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.

    Michiyo Imai;Hideo Shimada;Yoshihito Watanabe;Yuko Matsushima-Hibiya

  • Size‐Selective Olefin Hydrogenation by a Pd Nanocluster Provided in an Apo‐Ferritin Cage

    Takafumi Ueno;Masako Suzuki;Toshiaki Goto;Tomoharu Matsumoto

  • Reactive iron porphyrin derivatives related to the catalytic cycles of cytochrome P-450 and peroxidase. Studies of the mechanism of oxygen activation

    John Taylor Groves;Yoshihito Watanabe

  • Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450, chloroperoxidase, and catalase.

    Shin Ichi Adachi;Shingo Nagano;Koichiro Ishimori;Yoshihito Watanabe

  • Preparation of artificial metalloenzymes by insertion of chromium(III) Schiff base complexes into apomyoglobin mutants.

    Masataka Ohashi;Tomomi Koshiyama;Takafumi Ueno;Manabu Yanase

  • The mechanism of olefin epoxidation by oxo-iron porphyrins. Direct observation of an intermediate.

    John Taylor Groves;Yoshihito Watanabe

  • pH-Dependent Transfer Hydrogenation of Ketones with HCOONa as a Hydrogen Donor Promoted by (η6-C6Me6)Ru Complexes

    Seiji Ogo;Tsutomu Abura;Yoshihito Watanabe

  • Coordinated Design of Cofactor and Active Site Structures in Development of New Protein Catalysts

    Takafumi Ueno;Tomomi Koshiyama;Masataka Ohashi;Kazuyoshi Kondo

  • Effects of the location of distal histidine in the reaction of myoglobin with hydrogen peroxide.

    Toshitaka Matsui;Shin Ichi Ozaki;Elaine Liong;George N. Phillips

  • Isolation and crystal structure of a water-soluble iridium hydride: a robust and highly active catalyst for acid-catalyzed transfer hydrogenations of carbonyl compounds in acidic media.

    Tsutomu Abura;Seiji Ogo;Yoshihito Watanabe;Shunichi Fukuzumi

  • pH-Dependent Transfer Hydrogenation of Water-Soluble Carbonyl Compounds with [Cp*IrIII(H2O)3]2+ (Cp* = η5-C5Me5) as a Catalyst Precursor and HCOONa as a Hydrogen Donor in Water

    Seiji Ogo;Nobuyuki Makihara;Yoshihito Watanabe

  • pH-dependent transfer hydrogenation, reductive amination, and dehalogenation of water-soluble carbonyl compounds and alkyl halides promoted by Cp*Ir complexes

    Seiji Ogo;Nobuyuki Makihara;Yuichi Kaneko;Yoshihito Watanabe

  • Reactivities of oxo and peroxo intermediates studied by hemoprotein mutants.

    Yoshihito Watanabe;Hiroshi Nakajima;Takafumi Ueno

  • Polymerization of phenylacetylene by rhodium complexes within a discrete space of apo-ferritin.

    Satoshi Abe;Kunio Hirata;Takafumi Ueno;Kazuhide Morino

  • Mechanisms of Sulfoxidation Catalyzed by High-Valent Intermediates of Heme Enzymes: Electron-Transfer vs Oxygen-Transfer Mechanism

    Yoshio Goto;Toshitaka Matsui;Shin Ichi Ozaki;Yoshihito Watanabe

  • Synthesis, Structures, and Properties of Bis(μ-oxo)nickel(III) and Bis(μ-superoxo)nickel(II) Complexes: An Unusual Conversion of a NiIII2(μ-O)2 Core into a NiII2(μ-OO)2 Core by H2O2 and Oxygenation of Ligand

    Kazushi Shiren;Seiji Ogo;Shuhei Fujinami;Hideki Hayashi

  • Investigations of the roles of the distal heme environment and the proximal heme iron ligand in peroxide activation by heme enzymes via molecular engineering of myoglobin.

    Shin-ichi Ozaki,†,‡,§;Mark P. Roach;Toshitaka Matsui,†,‡,‖ and;Yoshihito Watanabe

  • Direct observation of the push effect on the oxygen-oxygen bond cleavage of acylperoxoiron(III) porphyrin complexes

    Kazuya Yamaguchi;Yoshihito Watanabe;Isao Morishima

  • Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules

    Osami Shoji;Tatsuya Kunimatsu;Norifumi Kawakami;Yoshihito Watanabe

  • Acylperoxo-Iron(III) Porphyrin Complexes: A New Entry of Potent Oxidants for the Alkene Epoxidation

    Kenji Machii;Yoshihito Watanabe;Isao Morishima

Frequent Co-Authors

Takafumi Ueno
Takafumi Ueno Tokyo Institute of Technology
Isao Morishima
Isao Morishima Kyoto University
Yoshitsugu Shiro
Yoshitsugu Shiro University of Hyogo
Shunichi Fukuzumi
Shunichi Fukuzumi Osaka University
Teizo Kitagawa
Teizo Kitagawa University of Hyogo
Katsuomi Takehira
Katsuomi Takehira Hiroshima University
John T. Groves
John T. Groves Princeton University
Shun Hirota
Shun Hirota Nara Institute of Science and Technology
Hideki Masuda
Hideki Masuda Nagoya Institute of Technology
Koichiro Ishimori
Koichiro Ishimori Hokkaido University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Chemistry, exploring related fields such as forensic science can open diverse career opportunities. Many professionals in forensic science rely on strong chemistry skills to analyze evidence and support criminal investigations. Pursuing an online master's in forensic psychology can complement a Chemistry background by enhancing understanding of behavioral aspects relevant to crime scene analysis.

The forensic career landscape includes roles like forensic chemist, crime lab analyst, and toxicologist, all of which benefit from in-depth chemistry knowledge. For those considering stepping into this field, learning more about forensic careers is a great starting point.

When evaluating educational paths, understanding the financial commitment is crucial. Resources explaining how much does a criminal justice degree cost provide valuable insights into program expenses and budgeting for your studies.

For those just beginning their academic journey, pursuing a criminal justice associate degree online can be an affordable and flexible way to enter the field and build a foundation for more advanced studies.

Best Scientists Citing Yoshihito Watanabe

Trending Scientists