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Yoshitsugu Shiro

Yoshitsugu Shiro

D-Index & Metrics

Chemistry

D-Index
66
Citations
12268
World Ranking
7486
National Ranking
496

Overview

Yoshitsugu Shiro is affiliated with the University of Hyogo in Japan. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant number of publications in molecular biology. Other notable subfields include radiation, cell biology, genetics, and physiology.

The main research topics explored by Yoshitsugu Shiro cover photosynthetic processes and mechanisms, hemoglobin structure and function, porphyrin metabolism and disorders, metal-catalyzed oxygenation mechanisms, advanced X-ray imaging techniques, bacterial genetics and biotechnology, and pharmacogenetics and drug metabolism.

Yoshitsugu Shiro has authored several recent scientific papers including:

  • Short-lived intermediate in N 2 O generation by P450 NO reductase captured by time-resolved IR spectroscopy and XFEL crystallography, 2021, Proceedings of the National Academy of Sciences
  • Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria, 2022, Proceedings of the National Academy of Sciences
  • XFEL Crystal Structures of Peroxidase Compound II, 2021, Angewandte Chemie International Edition
  • Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain, 2020, Angewandte Chemie International Edition
  • Timing of NO Binding and Protonation in the Catalytic Reaction of Bacterial Nitric Oxide Reductase as Established by Time-Resolved Spectroscopy, 2020, Bulletin of the Chemical Society of Japan

Frequent coauthors collaborating with Yoshitsugu Shiro include Takehiko Tosha, Hiroshi Sugimoto, Hitomi Sawai, Masaki Yamamoto, and Keitaro Yamashita.

Their work is published in a range of scientific venues, with repeated publications appearing in Zenodo (CERN European Organization for Nuclear Research), IOP Conference Series Materials Science and Engineering, Proceedings of the National Academy of Sciences, Angewandte Chemie International Edition, and The Journal of Physical Chemistry B.

Best Publications

  • Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase.

    Hiroshi Sugimoto;Shun-ichiro Oda;Takashi Otsuki;Tomoya Hino

  • Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase

    Tomoya Hino;Yushi Matsumoto;Shingo Nagano;Hiroshi Sugimoto

  • 1.25 a resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms.

    Sam-Yong Park;Takeshi Yokoyama;Naoya Shibayama;Yoshitsugu Shiro

  • Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies

    Dong-Sun Lee;Akari Yamada;Hiroshi Sugimoto;Isamu Matsunaga

  • Crystal structure of nitric oxide reductase from denitrifying fungus Fusarium oxysporum.

    S Y Park;H Shimizu;S Adachi;A Nakagawa

  • Spectroscopic and Kinetic Studies on Reaction of Cytochrome P450nor with Nitric Oxide IMPLICATION FOR ITS NITRIC OXIDE REDUCTION MECHANISM

    Yoshitsugu Shiro;Motoyasu Fujii;Tetsutaro Iizuka;Shin-ichi Adachi

  • Specific damage induced by X-ray radiation and structural changes in the primary photoreaction of bacteriorhodopsin.

    Yasuhiro Matsui;Keisuke Sakai;Midori Murakami;Yoshitsugu Shiro

  • Sensory mechanism of oxygen sensor FixL from Rhizobium meliloti: crystallographic, mutagenesis and resonance Raman spectroscopic studies

    Hideyuki Miyatake;Masahiro Mukai;Sam-Yong Park;Shin-ichi Adachi

  • Light-dependent regulation of structural flexibility in a photochromic fluorescent protein

    Hideaki Mizuno;Tapas Kumar Mal;Markus Wälchli;Akihiro Kikuchi

  • Hydrogen Peroxide Dependent Monooxygenations by Tricking the Substrate Recognition of Cytochrome P450BSβ

    Osami Shoji;Takashi Fujishiro;Hiroshi Nakajima;Misa Kim

  • Crystal structure of H2O2-dependent cytochrome P450SPalpha with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the alpha position.

    Takashi Fujishiro;Osami Shoji;Shingo Nagano;Hiroshi Sugimoto

  • Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton

    Masatomo Makino;Hiroshi Sugimoto;Yoshitsugu Shiro;Shumpei Asamizu

  • Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus.

    Yushi Matsumoto;Takehiko Tosha;Andrei V Pisliakov;Tomoya Hino

  • Presence of endogenous calcium ion and its functional and structural regulation in horseradish peroxidase.

    Y Shiro;M Kurono;I Morishima

  • Structural basis of human cytoglobin for ligand binding.

    Hiroshi Sugimoto;Masatomo Makino;Hitomi Sawai;Norifumi Kawada

  • Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties.

    Sam Yong Park;Kazuhide Yamane;Shin Ichi Adachi;Yoshitsugu Shiro

  • Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes

    Hideaki Shimizu;Eiji Obayashi;Yuki Gomi;Hiroshi Arakawa

  • The Crystal Structures of the Ferric and Ferrous Forms of the Heme Complex of HmuO, a Heme Oxygenase of Corynebacterium diphtheriae

    Shoko Hirotsu;Grace C. Chu;Masaki Unno;Dong Sun Lee

  • NO Reduction by Nitric-oxide Reductase from Denitrifying Bacterium Pseudomonas aeruginosa CHARACTERIZATION OF REACTION INTERMEDIATES THAT APPEAR IN THE SINGLE TURNOVER CYCLE

    Hideyuki Kumita;Koji Matsuura;Tomoya Hino;Satoshi Takahashi

  • Structure of PAS-linked histidine kinase and the response regulator complex

    Seiji Yamada;Hiroshi Sugimoto;Miki Kobayashi;Ayako Ohno

  • Unique binding of nitric oxide to ferric nitric oxide reductase from Fusarium oxysporum elucidated with infrared, resonance Raman, and X-ray absorption spectroscopies

    Eiji Obayashi;Koki Tsukamoto;Shin Ichi Adachi;Satoshi Takahashi

  • Calcium binding by horseradish peroxidase c and the heme environmental structure

    Satoshi Ogawa;Yoshitsugu Shiro;Isao Morishima

Frequent Co-Authors

Shin-ichi Adachi
Shin-ichi Adachi High Energy Accelerator Research Organization
Yoshihito Watanabe
Yoshihito Watanabe Nagoya University
Takashi Ogura
Takashi Ogura University of Hyogo
Isao Morishima
Isao Morishima Kyoto University
Seiki Kuramitsu
Seiki Kuramitsu Osaka University
Hirofumi Shoun
Hirofumi Shoun University of Tokyo
S. Samar Hasnain
S. Samar Hasnain University of Liverpool
Yuji Sugita
Yuji Sugita RIKEN Center for Biosystems Dynamics Research
Katsutoshi Yoshizato
Katsutoshi Yoshizato Osaka Metropolitan University

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