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Michael Kirschfink

Michael Kirschfink

D-Index & Metrics

Microbiology

D-Index
60
Citations
11490
World Ranking
3161
National Ranking
235

Overview

Michael Kirschfink is affiliated with Heidelberg University in Germany and has contributed extensively to research in the fields of Immunology and Microbiology as well as Medicine. Their work prominently features studies on the complement system in diseases, coagulation processes, autoimmune disorders, and renal pathologies.

The scientist's major topics of research include:

  • Complement system in diseases
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Renal Diseases and Glomerulopathies
  • Blood groups and transfusion
  • Immunodeficiency and Autoimmune Disorders
  • Monoclonal and Polyclonal Antibodies Research
  • Immune Cell Function and Interaction

Michael Kirschfink has published significant papers across various respected journals. Notable recent publications include:

  • European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management, 2020, Journal of Clinical Immunology
  • Neutrophils activated by membrane attack complexes increase the permeability of melanoma blood vessels, 2022, Proceedings of the National Academy of Sciences
  • Expanding Horizons in Complement Analysis and Quality Control, 2021, Frontiers in Immunology
  • Janus kinase inhibition in complement component 1 deficiency, 2020, Journal of Allergy and Clinical Immunology
  • H1N1 Infection Reduces Glucose Level in Human U937 Monocytes Culture, 2020, Viral Immunology

The scientist frequently collaborates with certain coauthors, including Ashley Frazer-Abel, Anete Sevciovic Grumach, Zoltán Prohászka, Mahmoud Mohamed Bahgat, and Sabine Goseberg.

Michael Kirschfink's research has been published mainly in the following venues:

  • Frontiers in Immunology
  • Trillium Immunologie
  • Journal of Clinical Immunology
  • Proceedings of the National Academy of Sciences
  • Journal of Allergy and Clinical Immunology

Their subfields of study reflect a focus not only in immunology but also in related biomedical disciplines, such as hematology, genetics, nephrology, and physiology.

Best Publications

  • Obstacles to cancer immunotherapy: expression of membrane complement regulatory proteins (mCRPs) in tumors.

    Z Fishelson;N Donin;S Zell;S Schultz

  • Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease): An Update

    Gerald B. Appel;H. Terence Cook;Gregory Hageman;J. Charles Jennette

  • Eculizumab in severe Shiga-toxin-associated HUS.

    Anne-Laure Lapeyraque;Michal Malina;Véronique Fremeaux-Bacchi;Tobias Boppel

  • Eculizumab for atypical hemolytic-uremic syndrome.

    Jens Nürnberger;Thomas Philipp;Oliver Witzke;Anabelle Opazo Saez

  • Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins

    Peter Kraiczy;Jens Hellwage;Christine Skerka;Heiko Becker

  • Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1/reconectin and Factor H.

    Peter Kraiczy;Christine Skerka;Michael Kirschfink;Volker Brade

  • Complement in human diseases: Lessons from complement deficiencies.

    Marina Botto;Michael Kirschfink;Paolo Macor;Matthew C. Pickering

  • Complement resistance of tumor cells: basal and induced mechanisms.

    K Jurianz;S Ziegler;H Garcia-Schüler;S Kraus

  • Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

    C. Licht;S. Heinen;M. Józsi;I. Löschmann

  • An international serum standard for application in assays to detect human complement activation products

    Grethe Bergseth;Judith K. Ludviksen;Michael Kirschfink;Patricia C. Giclas

  • Controlling the complement system in inflammation

    Michael Kirschfink

  • Complement Inhibitor Eculizumab in Atypical Hemolytic Uremic Syndrome

    Christoph J. Mache;Birgit Acham-Roschitz;Veronique Frémeaux-Bacchi;Michael Kirschfink

  • Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach.

    Anete Sevciovic Grumach;Michael Kirschfink

  • Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1.

    Kristina Hartmann;Carsten Corvey;Christine Skerka;Michael Kirschfink

  • Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family

    Peter Kraiczy;Jens Hellwage;Christine Skerka;Michael Kirschfink

  • Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndrome.

    G. Zilow;J. A. Sturm;U. Rother;M. Kirschfink

  • Complement analysis in the 21st century.

    Tom Eirik Mollnes;Tom Eirik Mollnes;T. Sakari Jokiranta;Lennart Truedsson;Bo Nilsson

  • Targeting complement in therapy

    Michael Kirschfink

  • Mechanism of complement resistance of pathogenic Borrelia burgdorferi isolates.

    Peter Kraiczy;Christine Skerka;Michael Kirschfink;Peter F Zipfel

  • Complement resistance of human carcinoma cells depends on membrane regulatory proteins, protein kinases and sialic acid

    N. Donin;K. Jurianz;L. Ziporen;S. Schultz

  • Strategies of therapeutic complement inhibition.

    Tom E. Mollnes;Michael Kirschfink

  • Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15.

    Christoph Licht;Annic Weyersberg;Stefan Heinen;Ludwig Stapenhorst

Frequent Co-Authors

Peter F. Zipfel
Peter F. Zipfel Friedrich Schiller University Jena
Christine Skerka
Christine Skerka Leibniz Association
Peter Kraiczy
Peter Kraiczy Goethe University Frankfurt
Reinhard Wallich
Reinhard Wallich Heidelberg University
Tom Eirik Mollnes
Tom Eirik Mollnes Oslo University Hospital
Markus M. Simon
Markus M. Simon Max Planck Society
Bo Nilsson
Bo Nilsson Uppsala University
Antonio Condino-Neto
Antonio Condino-Neto Universidade de São Paulo
Norbert Gretz
Norbert Gretz Heidelberg University

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