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Christine Skerka

Christine Skerka

D-Index & Metrics

Microbiology

D-Index
78
Citations
19032
World Ranking
1308
National Ranking
87

Overview

Christine Skerka is affiliated with the Leibniz Association in Germany and has contributed extensively to research in medicine and immunology and microbiology. Their academic focus covers key areas such as immunology, nephrology, genetics, epidemiology, and hematology, with a particular concentration on the complement system's role in various diseases.

Their work frequently addresses the complement system in diseases, renal diseases and glomerulopathies, coagulation and angioedema mechanisms, bacterial infections and vaccines, blood groups and transfusion, hemoglobinopathies and related disorders, and the role of extracellular vesicles in disease processes.

Christine Skerka's research is published in a range of scientific journals, with notable frequent publication venues including:

  • Immunobiology
  • Scientific Reports
  • Journal of the American Society of Nephrology
  • European Journal of Immunology
  • Frontiers in Immunology

Their recent papers include:

  • CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy, 2020, Journal of the American Society of Nephrology
  • Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles, 2020, Nature Communications
  • Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth, 2022, mBio
  • The Protease SplB of Staphylococcus aureus Targets Host Complement Components and Inhibits Complement-Mediated Bacterial Opsonophagocytosis, 2021, Journal of Bacteriology
  • A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes, 2020, Proceedings of the National Academy of Sciences

Frequent co-authors who have collaborated with Christine Skerka include:

  • Peter F. Zipfel
  • Thorsten Wiech
  • Andrea Hartmann
  • Christoph J. Binder
  • Luce Perie

Best Publications

  • Complement regulators and inhibitory proteins.

    Peter F. Zipfel;Christine Skerka

  • Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

    David Weismann;Karsten Hartvigsen;Karsten Hartvigsen;Karsten Hartvigsen;Nadine Lauer;Keiryn L. Bennett

  • Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency

    Mihály Józsi;Christoph Licht;Stefanie Strobel;Svante L. H. Zipfel

  • Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

    Peter F Zipfel;Matthew Edey;Stefan Heinen;Mihály Józsi

  • Factor H–related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

    Stefan Heinen;Andrea Hartmann;Nadine Lauer;Ulrike Wiehl

  • Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins

    Peter Kraiczy;Jens Hellwage;Christine Skerka;Heiko Becker

  • The Molecular Basis of Familial Hemolytic Uremic Syndrome: Mutation Analysis of Factor H Gene Reveals a Hot Spot in Short Consensus Repeat 20

    Jessica Caprioli;Paola Bettinaglio;Peter F. Zipfel;Barbara Amadei

  • Atypical aHUS: State of the art.

    Carla M. Nester;Thomas Barbour;Santiago Rodriquez de Cordoba;Marie Agnes Dragon-Durey

  • Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1/reconectin and Factor H.

    Peter Kraiczy;Christine Skerka;Michael Kirschfink;Volker Brade

  • Complement factor H related proteins (CFHRs)

    Christine Skerka;Qian Chen;Veronique Fremeaux-Bacchi;Lubka T. Roumenina;Lubka T. Roumenina;Lubka T. Roumenina

  • Factor H family proteins: on complement, microbes and human diseases.

    P. F. Zipfel;C. Skerka;J. Hellwage;S. T. Jokiranta

  • Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1.

    S Kühn;C Skerka;P F Zipfel

  • ApoE attenuates unresolvable inflammation by complex formation with activated C1q

    Changjun Yin;Susanne Ackermann;Zhe Ma;Sarajo K. Mohanta

  • Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)

    Maria Asuncion Abrera-Abeleda;Carla Nishimura;Jenna L.H. Smith;Sanjjev Sethi

  • Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countries

    H P H Neumann;M Salzmann;B Bohnert-Iwan;T Mannuelian

  • Anti–factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome

    Mihály Józsi;Stefanie Strobel;Hans-Martin Dahse;Wei-shih Liu

  • Further Characterization of Complement Regulator-Acquiring Surface Proteins of Borrelia burgdorferi

    Peter Kraiczy;Christine Skerka;Volker Brade;Peter F. Zipfel

  • Complement and diseases: defective alternative pathway control results in kidney and eye diseases.

    Peter F. Zipfel;Stefan Heinen;Mihály Józsi;Christine Skerka

  • Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

    C. Licht;S. Heinen;M. Józsi;I. Löschmann

  • Hypocomplementemia Discloses Genetic Predisposition to Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura Role of Factor H Abnormalities

    Marina Noris;Piero Ruggenenti;Annalisa Perna;Silvia Orisio

  • The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models.

    Rebecca E. Saunders;Cynthia Abarrategui-Garrido;Véronique Frémeaux-Bacchi;Elena Goicoechea de Jorge

Frequent Co-Authors

Peter F. Zipfel
Peter F. Zipfel Friedrich Schiller University Jena
Peter Kraiczy
Peter Kraiczy Goethe University Frankfurt
Reinhard Wallich
Reinhard Wallich Heidelberg University
Michael Kirschfink
Michael Kirschfink Heidelberg University
Mihály Józsi
Mihály Józsi Eötvös Loránd University
Bernhard H. F. Weber
Bernhard H. F. Weber University of Regensburg
Timothy H.J. Goodship
Timothy H.J. Goodship Newcastle University
Brian Stevenson
Brian Stevenson University of Kentucky
Markus M. Simon
Markus M. Simon Max Planck Society
Marina Noris
Marina Noris Mario Negri Institute for Pharmacological Research

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