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Lars-Åke Fransson

Lars-Åke Fransson

Overview

Lars-Åke Fransson is affiliated with Lund University in Sweden and works primarily within the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their published research is concentrated on topics including Alzheimer's disease research and treatments, Parkinson's Disease mechanisms and treatments, neurogenesis and neuroplasticity mechanisms, sphingolipid metabolism and signaling, polysaccharides and plant cell walls, cellular transport and secretion, and endoplasmic reticulum stress and disease.

Fransson's recent publications span several well-regarded scientific journals. Notable works include:

  • Complex modulation of cytokine-induced α-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells, 2021, Glycobiology
  • Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1, 2020, Glycobiology
  • Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells, 2023, Glycobiology
  • Modulation of pTau181 by Glypican-1-Derived Heparan Sulfate in Human Neural Progenitor Cells and ApoE4 -Expressing Induced Neurons, 2025, Journal of Neurochemistry
  • Interplay between Glypican-1, Amyloid-B and Tau Phosphorylation in Human Neural Stem Cells, 2024, SSRN Electronic Journal

Frequent co-authors collaborating with Fransson include:

  • Fang Cheng
  • Katrin Mani

Their publications are primarily found in venues such as:

  • Glycobiology
  • Journal of Neurochemistry
  • SSRN Electronic Journal

Fransson's research covers subfields including physiology, neurology, molecular biology, cell biology, and developmental neuroscience. This interdisciplinary approach supports their focus on neurodegenerative diseases and molecular cellular processes involved in neural function and pathology.

Best Publications

  • Structure of the antithrombin-binding site in heparin

    Ulf Lindahl;Gudrun Backstrom;Magnus Hook;Lennart Thunberg

  • Structure and function of cell-associated proteoglycans

    Lars-Åke Fransson

  • Glypican-1 Is a Vehicle for Polyamine Uptake in Mammalian Cells A PIVOTAL ROLE FOR NITROSOTHIOL-DERIVED NITRIC OXIDE

    Mattias Belting;Katrin Mani;Mats Jönsson;Fang Cheng

  • Novel aspects of glypican glycobiology.

    Lars-Åke Fransson;Mattias Belting;Fang Cheng;M Jönsson

  • Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine.

    I Carlstedt;A Herrmann;Hasse Karlsson;J Sheehan

  • Biosynthesis of dermatan sulfate. I. Formation of L-iduronic acid residues.

    A Malmström;L A Fransson

  • Structure of dermatan sulfate. VII. The copolymeric structure of dermatan sulfate from horse aorta.

    Lars-Åke Fransson;Birgitta Havsmark

  • Tumor attenuation by combined heparan sulfate and polyamine depletion

    Mattias Belting;Lubor Borsig;Mark M. Fuster;Jillian R. Brown

  • Patterns of uronosyl epimerization and 4-/6-O-sulphation in chondroitin/dermatan sulphate from decorin and biglycan of various bovine tissues.

    Fang Cheng;Dick Heinegård;Anders Malmström;Artur Schmidtchen

  • Proteoglycan involvement in polyamine uptake.

    Mattias Belting;Susanne Persson;Lars-Åke Fransson

  • Proliferation of cultured fibroblasts is inhibited by L-iduronate-containing glycosaminoglycans.

    Gunilla Westergren‐Thorsson;Per‐Ola Önnervik;Lars‐ÅKe Fransson;Anders Malmström

  • Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes.

    Fang Cheng;Katrin Mani;Jacob van den Born;Kan Ding

  • The copolymeric structure of dermatan sulphate produced by cultured human fibroblasts. Different distribution of iduronic acid and glucuronic acid-containing units in soluble and cell-associated glycans.

    A Malström;I Carlstedt;L Aberg;L A Fransson

  • Hunter's syndrome: A deficiency of L-idurono-sulfate sulfatase

    Ingrid Sjöberg;Lars Ake Fransson;Reuben Matalon;Albert Dorfman

  • Biosynthesis of heparin. III. Formation of iduronic acid residues

    Magnus Höök;Ulf Lindahl;Gudrun Bäckström;Anders Malmström

  • METHOD OF PRODUCING DEPOLYMERIZED HEPARIN

    Lindal Ulf Per Fredrik;Bekstren Gudrun Elizabet;Tunberg Dzhon Yungve Lennart;Fransson Lars-Oke

  • Periodate oxidation and alkaline degradation of heparin-related glycans

    Lars-Åke Fransson;Anders Malmström;Ingrid Sjöberg;Thomas N. Huckerby

  • Biosynthesis of L-iduronic acid in heparin: Epimerization of D-glucuronic acid on the polymer level

    Ulf Lindahl;Gudrun Bäckström;Anders Malmström;Lars-Åke Fransson

  • Inventory of human skin fibroblast proteoglycans. Identification of multiple heparan and chondroitin/dermatan sulphate proteoglycans.

    Artur Schmidtchen;Ingemar Carlstedt;Anders Malmström;Lars-Åke Fransson

  • Structural studies on heparan sulphates. Characterization of oligosaccharides; obtained by periodate oxidation and alkaline elimination.

    Lars-Åke Fransson;Ingrid Sjöberg;Birgitta Havsmark

Frequent Co-Authors

Mattias Belting
Mattias Belting Lund University
Anders Malmström
Anders Malmström Lund University
Artur Schmidtchen
Artur Schmidtchen Lund University
Åke Oldberg
Åke Oldberg Lund University
Ingemar Carlstedt
Ingemar Carlstedt Lund University
Roberto Cappai
Roberto Cappai University of Melbourne
Dick Heinegård
Dick Heinegård Lund University
Ulf Lindahl
Ulf Lindahl Uppsala University
Gerd Multhaup
Gerd Multhaup McGill University
Colin L. Masters
Colin L. Masters University of Melbourne

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