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Dick Heinegård

Dick Heinegård

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
116
Citations
45814
World Ranking
753
National Ranking
13

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Dick Heinegård was a researcher affiliated with Lund University in Sweden. Their scientific work focused extensively on the biomedical field, particularly in medicine with a strong intersection in biochemistry, genetics, and molecular biology. The subfields of their research included rheumatology, cell biology, surgery, molecular biology, and biomedical engineering.

The scientist's research topics covered a variety of areas related to musculoskeletal health and cellular biology. Key topics addressed in their publications included osteoarthritis treatment and mechanisms, knee injuries and reconstruction techniques, proteoglycans and glycosaminoglycans research, cell adhesion molecules research, cellular mechanics and interactions, tendon structure and treatment, and spine and intervertebral disc pathology.

Heinegård published extensively in multiple scientific venues, with notable frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Biomaterialia
  • Osteoarthritis and Cartilage
  • Biofabrication
  • Journal of Bone and Mineral Research

Their recent significant papers include:

  • Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages (2021), Biomaterials
  • Targeting cartilage EGFR pathway for osteoarthritis treatment (2021), Science Translational Medicine
  • 4D printing of self-folding and cell-encapsulating 3D microstructures as scaffolds for tissue-engineering applications (2020), Biofabrication
  • Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis (2020), Acta Biomaterialia
  • Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization (2020), Scientific Reports

Throughout their career, Heinegård collaborated frequently with several researchers including Robert L. Mauck, X. Lucas Lu, Biao Han, Bryan Kwok, and Eiki Koyama.

In addition to articles, the scientist contributed to book literature, notably publishing "Electromechanobiology of Cartilage and Osteoarthritis" in 2023 through Springer Nature.

Best Publications

  • Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence

    A Oldberg;A Franzén;D Heinegård

  • Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.

    A Hildebrand;M Romarís;L M Rasmussen;D Heinegård

  • Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon.

    K G Vogel;M Paulsson;D Heinegård

  • Osteopontin--a possible anchor of osteoclasts to bone.

    Finn P. Reinholt;Kjell Hultenby;Ake Oldberg;Dick Heinegard

  • Structure and biology of cartilage and bone matrix noncollagenous macromolecules.

    Dick Heinegård;åke Oldberg

  • Aggregation of Cartilage Proteoglycans I. THE ROLE OF HYALURONIC ACID

    Vincent C. Hascall;Dick Heinegård

  • Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.

    E. Hedbom;P. Antonsson;A. Hjerpe;Daniel Aeschlimann

  • Aggregation of Cartilage Proteoglycans: III. CHARACTERISTICS OF THE PROTEINS ISOLATED FROM TRYPSIN DIGESTS OF AGGREGATES

    Dick Heinegård;Vincent C. Hascall

  • The role of the cartilage matrix in osteoarthritis

    Dick Heinegård;Tore Saxne

  • Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon.

    Liz Svensson;Attila Aszódi;Finn P. Reinholt;Reinhard Fässler

  • Prognostic laboratory markers of joint damage in rheumatoid arthritis

    Elisabet Lindqvist;Kerstin Eberhardt;Klaus Bendtzen;Dick Heinegard

  • Aggregation of cartilage proteoglycans. II. Oligosaccharide competitors of the proteoglycan-hyaluronic acid interaction.

    Vincent C. Hascall;Dick Heinegård

  • Cartilage Oligomeric Matrix Protein Shows High Affinity Zinc-dependent Interaction with Triple Helical Collagen

    Krisztina Rosenberg;Henric Olsson;Matthias Mörgelin;Dick Heinegård

  • Classification of osteoarthritis biomarkers: a proposed approach

    D. C. Bauer;D. J. Hunter;S. B. Abramson;M. Attur

  • Binding of fibromodulin and decorin to separate sites on fibrillar collagens.

    E Hedbom;D Heinegård

  • The primary structure of a cell-binding bone sialoprotein.

    A Oldberg;A Franzén;D Heinegård

  • Interaction of a 59-kDa connective tissue matrix protein with collagen I and collagen II.

    E Hedbom;D Heinegård

  • COMP acts as a catalyst in collagen fibrillogenesis.

    Krisztina Halász;Anja Kassner;Matthias Mörgelin;Dick Heinegård

  • COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins.

    A Oldberg;P Antonsson;K Lindblom;D Heinegård

  • The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.

    Anders Aspberg;Ryu Miura;Sandrine Bourdoulous;Motoyuki Shimonaka

Frequent Co-Authors

Tore Saxne
Tore Saxne Lund University
Matthias Mörgelin
Matthias Mörgelin Lund University
Åke Oldberg
Åke Oldberg Lund University
Anna M. Blom
Anna M. Blom Lund University
Mats Paulsson
Mats Paulsson University of Cologne
Jörgen Wieslander
Jörgen Wieslander Lund University
Anna Teti
Anna Teti University of L'Aquila
Kjell Hultenby
Kjell Hultenby Karolinska Institute
Jürgen Engel
Jürgen Engel University of Basel
Anders Malmström
Anders Malmström Lund University

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