Don W. Cleveland

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United States Leader Award
• 2025 - Research.com Best Scientists Award
• 2025 - Research.com Biology and Biochemistry in United States Leader Award
• 2023 - Research.com Biology and Biochemistry in United States Leader Award
• 2018 - Breakthrough Prize in Life Sciences for elucidating the molecular pathogenesis of a type of inherited ALS, including the role of glia in neurodegeneration, and for establishing antisense oligonucleotide therapy in animal models of ALS and Huntington disease.
• 2012 - Member of the National Academy of Medicine (NAM)
• 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
• 2006 - Fellow of the American Academy of Arts and Sciences
• 2006 - Member of the National Academy of Sciences
• 1999 - Sheila Essey Award for ALS Research, American Academy of Neurology

Overview

Best Publications

• Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

  Don W. Cleveland;Stuart G. Fischer;Marc W. Kirschner;Ulrich K. Laemmli

  6498
  Citations

• Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

  Don W. Cleveland;Margaret A. Lopata;Raymond J. MacDonald;Nicholas J. Cowan

  2045
  Citations

• Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

  Séverine Boillée;Koji Yamanaka;Christian S. Lobsiger;Neal G. Copeland

  1922
  Citations

• Decoding ALS: from genes to mechanism

  J. Paul Taylor;Robert H. Brown;Don W. Cleveland;Don W. Cleveland

  1896
  Citations

• Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.

  Shuo-Chien Ling;Magdalini Polymenidou;Don W. Cleveland

  1771
  Citations

• An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

  Philip C Wong;Carlos A Pardo;David R Borchelt;Michael K Lee

  1744
  Citations

• ALS: a disease of motor neurons and their nonneuronal neighbors.

  Séverine Boillée;Christine Vande Velde;Don W. Cleveland

  1738
  Citations

• From charcot to lou gehrig: deciphering selective motor neuron death in als

  Don W. Cleveland;Jeffrey D. Rothstein

  1696
  Citations

• Unraveling the mechanisms involved in motor neuron degeneration in ALS.

  Lucie I. Bruijn;Timothy M. Miller;Don W. Cleveland

  1666
  Citations

• ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

  L. I. Bruijn;M. W. Becher;M. K. Lee;K. L. Anderson

  1616
  Citations

• Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1.

  Lucie I. Bruijn;Megan K. Houseweart;Shinsuke Kato;Karen L. Anderson

  1533
  Citations

• On the road to cancer: aneuploidy and the mitotic checkpoint.

  Geert J. P. L. Kops;Beth A. A. Weaver;Don W. Cleveland

  1497
  Citations

• Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

  Magdalini Polymenidou;Clotilde Lagier-Tourenne;Kasey R. Hutt;Stephanie C. Huelga

  1360
  Citations

• Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice.

  A. M. Clement;M. D. Nguyen;E. A. Roberts;E. A. Roberts;M. L. Garcia;M. L. Garcia

  1356
  Citations

• Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.

  Koji Yamanaka;Seung Joo Chun;Severine Boillee;Noriko Fujimori-Tonou

  1275
  Citations

• A Structural Scaffolding of Intermediate Filaments in Health and Disease

  Elaine Fuchs;Don W. Cleveland

  1261
  Citations

• Chromosomal instability drives metastasis through a cytosolic DNA response.

  Samuel F. Bakhoum;Samuel F. Bakhoum;Bryan Ngo;Ashley M. Laughney;Julie Ann Cavallo;Julie Ann Cavallo

  1241
  Citations

• Centromeres and Kinetochores: From Epigenetics to Mitotic Checkpoint Signaling

  Don W Cleveland;Yinghui Mao;Kevin F Sullivan

  1228
  Citations

• High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

  Margaret A. Lopata;Don W. Cleveland;Barbara Sollner-Webb

  1221
  Citations

• Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin.

  Don W. Cleveland;Shu-Ying Hwo;Marc W. Kirschner

  1176
  Citations