His primary scientific interests are in SOD1, Cell biology, Mutant, Amyotrophic lateral sclerosis and Superoxide dismutase. Zuoshang Xu has researched SOD1 in several fields, including Motor neuron and Mitochondrion. His biological study spans a wide range of topics, including Intermediate filament, Protein filament, Transfection and Anatomy.
His studies examine the connections between Amyotrophic lateral sclerosis and genetics, as well as such issues in Mutation, with regards to Actin and Filamentous actin. As part of the same scientific family, Zuoshang Xu usually focuses on Superoxide dismutase, concentrating on Molecular biology and intersecting with Neurodegeneration and Superoxide. His research investigates the connection with Small interfering RNA and areas like RNA interference which intersect with concerns in Enzyme complex.
Zuoshang Xu spends much of his time researching Amyotrophic lateral sclerosis, SOD1, RNA interference, Cell biology and Genetically modified mouse. His Amyotrophic lateral sclerosis research incorporates elements of Motor neuron, Neuroscience, Spinal cord and Neurodegeneration. As a part of the same scientific study, Zuoshang Xu usually deals with the SOD1, concentrating on Mitochondrion and frequently concerns with Mitochondrial permeability transition pore.
Zuoshang Xu's looking at RNA interference as part of his Genetics and RNA and RNA interference study. His research in Genetically modified mouse intersects with topics in Axoplasmic transport, Axon, Anatomy, Protein subunit and Wild type. The Mutant study combines topics in areas such as Molecular biology, Gene mutation and Enzyme.
His primary areas of investigation include Amyotrophic lateral sclerosis, Central nervous system, Neuroscience, Spinal cord and Genetic enhancement. The study of Amyotrophic lateral sclerosis is intertwined with the study of Cell biology in a number of ways. Zuoshang Xu combines subjects such as Motor neuron and Denervation with his study of Cell biology.
His Neuroscience research is multidisciplinary, relying on both Mutation, Mutant, Neurodegeneration and Gene knockdown. The Spinal cord study combines topics in areas such as Endocrinology, Lysosomal storage disease, Astrogliosis, Pathology and SOD1. In his research on the topic of SOD1, Homologous chromosome and Function is strongly related with RNA interference.
His primary areas of study are Central nervous system, Transgene, Genetic enhancement, Immunology and Amyotrophic lateral sclerosis. His studies deal with areas such as Gene delivery, Neuroscience, Gene knockdown and Pathogenesis as well as Transgene. His studies in Genetic enhancement integrate themes in fields like Cancer research and Transduction.
His Immunology research incorporates elements of RNA interference, RNAi Therapeutics and SOD1. His work on Spinal cord expands to the thematically related Amyotrophic lateral sclerosis.
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Asymmetry in the assembly of the RNAi enzyme complex.
Dianne S. Schwarz;György Hutvágner;Tingting Du;Zuoshang Xu.
Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1
Jiming Kong;Zuoshang Xu.
The Journal of Neuroscience (1998)
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity
David R. Borchelt;Michael K. Lee;Hilda S. Slunt;Michael Guarnieri.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
Zuoshang Xu;Linda C. Cork;John W. Griffin;Don W. Cleveland.
Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis
Chi Hong Wu;Claudia Fallini;Nicola Ticozzi;Pamela J. Keagle.
Neurofilaments are obligate heteropolymers in vivo
Michael K. Lee;Zuoshang Xu;Philip C. Wong;Don W. Cleveland.
Journal of Cell Biology (1993)
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons
Carlos A. Pardo;Zuoshang Xu;David R. Borchelt;Donald L. Price.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
Hitoshi Kikuchi;Gabriele Almer;Satoshi Yamashita;Christelle Guégan.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Designing siRNA that distinguish between genes that differ by a single nucleotide.
Dianne S. Schwarz;Hongliu Ding;Lori A. Kennington;Jessica T. Moore.
PLOS Genetics (2005)
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes.
Cynthia M. J. Higgins;Chelowha Jung;Zuoshang Xu.
BMC Neuroscience (2003)
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