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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
17879
World Ranking
12952
National Ranking
5517

Overview

Zuoshang Xu is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on fields related to Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Within these broader areas, they have contributed extensively to subfields including Neurology, Molecular Biology, Genetics, Cellular and Molecular Neuroscience, and Biomaterials.

The main topics of Xu's work include Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, biodegradable polymer synthesis and properties, Parkinson's Disease Mechanisms and Treatments, Prion Diseases and Protein Misfolding, RNA Research and Splicing, and Genetic Neurodegenerative Diseases.

Xu has published several recent papers across a variety of scientific journals. These include:

  • Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice (2022), PLoS ONE
  • Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models (2022), Acta Neuropathologica Communications
  • Imaging Net Retrograde Axonal Transport In Vivo: A Physiological Biomarker (2022), Annals of Neurology
  • TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord (2022), Cerebral Cortex
  • RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability (2024), bioRxiv (Cold Spring Harbor Laboratory)

Xu frequently collaborates with several researchers including Issa Olakunle Yusuf, Sepideh Parsi, Robert H. Brown, Tao Qiao, and Paul R. Thompson. These collaborations have resulted in multiple joint publications and contributions within their areas of study.

The most common venues for Xu's publications include Acta Neuropathologica Communications, bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Annals of Neurology, and Cerebral Cortex. Their focus on journal publications reflects consistent involvement in scientific discourse within these journals.

Best Publications

  • Asymmetry in the assembly of the RNAi enzyme complex.

    Dianne S. Schwarz;György Hutvágner;Tingting Du;Zuoshang Xu

  • Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1

    Jiming Kong;Zuoshang Xu

  • Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

    David R. Borchelt;Michael K. Lee;Hilda S. Slunt;Michael Guarnieri

  • Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis

    Chi Hong Wu;Claudia Fallini;Nicola Ticozzi;Pamela J. Keagle

  • Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

    Zuoshang Xu;Linda C. Cork;John W. Griffin;Don W. Cleveland

  • Neurofilaments are obligate heteropolymers in vivo

    Michael K. Lee;Zuoshang Xu;Philip C. Wong;Don W. Cleveland

  • Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

    Carlos A. Pardo;Zuoshang Xu;David R. Borchelt;Donald L. Price

  • Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

    Hitoshi Kikuchi;Gabriele Almer;Satoshi Yamashita;Christelle Guégan

  • Designing siRNA that distinguish between genes that differ by a single nucleotide.

    Dianne S. Schwarz;Hongliu Ding;Lori A. Kennington;Jessica T. Moore

  • Reactive astrocytes secrete lcn2 to promote neuron death

    Fangfang Bi;Cao Huang;Jianbin Tong;Guang Qiu

  • Several rAAV Vectors Efficiently Cross the Blood–brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System

    Hongwei Zhang;Bin Yang;Xin Mu;Xin Mu;Seemin Seher Ahmed

  • ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes.

    Cynthia M. J. Higgins;Chelowha Jung;Zuoshang Xu

  • Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS.

    Cynthia M. J. Higgins;Cheolwha Jung;Hongliu Ding;Zuoshang Xu

  • Regional modulation of neurofilament organization by myelination in normal axons.

    Sung Tsang Hsieh;Grahame J. Kidd;Thomas O. Crawford;Zuoshang Xu

  • Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis.

    Cheolwha Jung;Cynthia M. J. Higgins;Zuoshang Xu

  • Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M.

    D. L.-Y. Dong;Zuo-Shang Xu;M. R. Chevrier;R. J. Cotter

  • Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model

    Cheolwha Jung;Yongqi Rong;Susan Doctrow;Michel Baudry

  • Mitochondrial dysfunction and its role in motor neuron degeneration in ALS

    Giovanni Manfredi;Zuoshang Xu

  • Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.

    Bin Yang;Bin Yang;Shaoyong Li;Hongyan Wang;Yansu Guo;Yansu Guo

  • A construct with fluorescent indicators for conditional expression of miRNA

    Linghua Qiu;Hongyan Wang;Xugang Xia;Xugang Xia;Hongxia Zhou;Hongxia Zhou

Frequent Co-Authors

Don W. Cleveland
Don W. Cleveland University of California, San Diego
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Donald L. Price
Donald L. Price Johns Hopkins University
John W. Griffin
John W. Griffin Johns Hopkins University
Phillip D. Zamore
Phillip D. Zamore University of Massachusetts Chan Medical School
David R. Borchelt
David R. Borchelt University of Florida
Sangram S. Sisodia
Sangram S. Sisodia University of Chicago
Gerald W. Hart
Gerald W. Hart University of Georgia
Sung-Tsang Hsieh
Sung-Tsang Hsieh National Taiwan University
Philip C. Wong
Philip C. Wong Johns Hopkins University School of Medicine

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