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Biology and Biochemistry

D-Index
138
Citations
66677
World Ranking
304
National Ranking
204

Overview

Gerald W. Hart is affiliated with the University of Georgia in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant emphasis on molecular biology, immunology, organic chemistry, cell biology, and cellular and molecular neuroscience as subfields of study.

The scientist's work centers on topics related to glycosylation and glycoproteins research, galectins and cancer biology, carbohydrate chemistry and synthesis, protein tyrosine phosphatases, RNA modifications and cancer, RNA and protein synthesis mechanisms, and ubiquitin and proteasome pathways.

Hart has a substantial publication record in several scientific venues. The most frequent publication venues include:

  • Journal of Biological Chemistry
  • Molecular & Cellular Proteomics
  • The FASEB Journal
  • FASEB BioAdvances
  • Frontiers in Immunology

Frequent coauthors in their research collaborations include Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, Roger Colbran, and Peter Cresswell. Each of these collaborators has contributed extensively alongside Hart in various studies.

Among their recent papers are:

  • "Analytical and Biochemical Perspectives of Protein O-GlcNAcylation," 2021, Chemical Reviews
  • "Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death," 2021, Circulation
  • "Targeting O-GlcNAcylation to develop novel therapeutics," 2020, Molecular Aspects of Medicine
  • "Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin," 2023, Cell
  • "Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms," 2020, Journal of Clinical Investigation

Best Publications

  • Essentials of Glycobiology [Internet]

    Ajit Varki;Richard D Cummings;Jeffrey D Esko;Pamela Stanley

  • Essentials of Glycobiology

    Ajit Varki;Richard D Cummings;Jeffrey D Esko;Hudson H Freeze

  • Cycling of O-linked β- N -acetylglucosamine on nucleocytoplasmic proteins

    Gerald Warren Hart;Michael P. Housley;Chad Slawson

  • Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease.

    Gerald W. Hart;Chad Slawson;Genaro Ramirez-Correa;Olof Lagerlof

  • Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc.

    C. R. Torres;Gerald Warren Hart

  • Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

    Lance Wells;Keith Vosseller;Gerald W. Hart

  • Symbol Nomenclature for Graphical Representations of Glycans.

    Ajit Varki;Richard D. Cummings;Markus Aebi;Nicole H. Packer

  • O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

    Fei Liu;Khalid Iqbal;Inge Grundke-Iqbal;Gerald Warren Hart

  • Dynamic Glycosylation of Nuclear and Cytosolic Proteins CLONING AND CHARACTERIZATION OF A UNIQUE O-GlcNAc TRANSFERASE WITH MULTIPLE TETRATRICOPEPTIDE REPEATS

    Lisa K. Kreppel;Melissa A. Blomberg;Gerald Warren Hart

  • The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

    Raheel Shafi;Sai Prasad N Iyer;Lesley G. Ellies;Niall O'Donnell

  • Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins CLONING AND CHARACTERIZATION OF A NEUTRAL, CYTOSOLIC β-N-ACETYLGLUCOSAMINIDASE FROM HUMAN BRAIN

    Yuan Gao;Lance Wells;Frank I. Comer;Glendon J. Parker

  • Glycomics Hits the Big Time

    Gerald Warren Hart;Ronald J. Copeland

  • Dynamic O-Linked Glycosylation of Nuclear and Cytoskeletal Proteins

    Gerald Warren Hart

  • Dynamic O-GlcNAc Modification of Nucleocytoplasmic Proteins in Response to Stress A SURVIVAL RESPONSE OF MAMMALIAN CELLS

    Natasha E. Zachara;Niall O'Donnell;Win D. Cheung;Jessica J. Mercer

  • Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

    Jeffrey R. Erickson;Laetitia Pereira;Lianguo Wang;Guanghui Han

  • Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

    Dennis L Y Dong;Gerald Warren Hart

  • Carbohydrates in chemistry and biology

    Beat Ernst;Gerald Warren Hart;Pierre Sinay

  • c-Myc Is Glycosylated at Threonine 58, a Known Phosphorylation Site and a Mutational Hot Spot in Lymphomas

    Teh-Ying Chou;Gerald W. Hart;Chi V. Dang

  • Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

    Keith Vosseller;Lance Wells;M. Daniel Lane;Gerald Warren Hart

  • Regulation of a Cytosolic and Nuclear O-GlcNAc Transferase ROLE OF THE TETRATRICOPEPTIDE REPEATS

    Lisa K. Kreppel;Gerald Warren Hart

Frequent Co-Authors

Beat Ernst
Beat Ernst University of Basel
Jeffrey D. Esko
Jeffrey D. Esko University of California, San Diego
Pamela Stanley
Pamela Stanley Albert Einstein College of Medicine
Carolyn R. Bertozzi
Carolyn R. Bertozzi Stanford University
Ajit Varki
Ajit Varki University of California, San Diego
Lance Wells
Lance Wells University of Georgia
Richard D. Cummings
Richard D. Cummings Harvard Medical School
Paul T. Englund
Paul T. Englund Johns Hopkins University
Robert N. Cole
Robert N. Cole Johns Hopkins University School of Medicine
Hudson H. Freeze
Hudson H. Freeze Discovery Institute

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