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Neuroscience

D-Index
89
Citations
27007
World Ranking
1158
National Ranking
594

Overview

Cheng-Xin Gong is affiliated with the City University of New York in the United States. Their research focuses primarily on the fields of Medicine and Neuroscience, with particular expertise in subfields such as Physiology, Molecular Biology, Neurology, Psychiatry and Mental Health, and Cellular and Molecular Neuroscience.

The scientist's main research topics include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Neuroscience and Neuropharmacology Research
  • Cholinesterase and Neurodegenerative Diseases
  • Prion Diseases and Protein Misfolding
  • Neurological Disease Mechanisms and Treatments

Cheng-Xin Gong has contributed through numerous publications in several scientific journals, including frequent appearances in the Journal of Alzheimer s Disease, Alzheimer s & Dementia, Frontiers in Aging Neuroscience, Acta Neuropathologica Communications, and the Journal of Biological Chemistry.

Selected recent papers authored or co-authored include:

  • "Truncation of Tau selectively facilitates its pathological activities," 2020, Journal of Biological Chemistry
  • "Multi-Targets: An Unconventional Drug Development Strategy for Alzheimer's Disease," 2022, Frontiers in Aging Neuroscience
  • "Alzheimer's disease brain contains tau fractions with differential prion-like activities," 2021, Acta Neuropathologica Communications
  • "Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice," 2020, Alzheimer s Research & Therapy
  • "Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK-3β in 3xTg-AD mice," 2020, Journal of Neurochemistry

The scientist has collaborated extensively with a group of frequent co-authors, including Khalid Iqbal, Fei Liu, Chun-Ling Dai, Yunn Chyn Tung, and Jianlan Gu.

Best Publications

  • Tau pathology in Alzheimer disease and other tauopathies

    Khalid Iqbal;Alejandra del C. Alonso;She Chen;M. Omar Chohan

  • Tau in Alzheimer disease and related tauopathies.

    Khalid Iqbal;Fei Liu;Cheng-Xin Gong;Inge Grundke-Iqbal

  • Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

    Fei Liu;Inge Grundke-Iqbal;Khalid Iqbal;Cheng-Xin Gong

  • O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease

    Fei Liu;Khalid Iqbal;Inge Grundke-Iqbal;Gerald Warren Hart

  • Tau and neurodegenerative disease: the story so far

    Khalid Iqbal;Fei Liu;Cheng-Xin Gong

  • Mechanisms of tau-induced neurodegeneration

    Khalid Iqbal;Fei Liu;Cheng-Xin Gong;Alejandra del C. Alonso

  • Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease.

    C.-X. Gong;K. Iqbal

  • Phosphoprotein phosphatase activities in Alzheimer disease brain.

    Cheng-Xin Gong;Toolsee J. Singh;Inge Grundke-Iqbal;Khalid Iqbal

  • Post-translational modifications of tau protein in Alzheimer's disease.

    C.-X. Gong;F. Liu;I. Grundke-Iqbal;K. Iqbal

  • Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain IMPLICATIONS FOR NEUROFIBRILLARY DEGENERATION IN ALZHEIMER'S DISEASE

    Cheng-Xin Gong;Theodore Lidsky;Jerzy Wegiel;Lorinda Zuck

  • Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

    Cheng‐Xin Gong;Sadia Shaikh;Jian‐Zhi Wang;Tanweer Zaidi

  • Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes.

    Ying Liu;Fei Liu;Inge Grundke-Iqbal;Khalid Iqbal

  • Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

    Fei Liu;Fei Liu;Jianhua Shi;Hitoshi Tanimukai;Jinhua Gu

  • Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

    Ying Liu;Fei Liu;Khalid Iqbal;Inge Grundke-Iqbal

  • Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B

    Jian-Zhi Wang;Cheng-Xin Gong;Tanweer Zaidi;Inge Grundke-Iqbal

  • Tau exon 10 alternative splicing and tauopathies

    Fei Liu;Fei Liu;Cheng-Xin Gong

  • The role of DYRK1A in neurodegenerative diseases

    Jerzy Wegiel;Cheng-Xin Gong;Yu-Wen Hwang

  • A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

    Yanxing Chen;Zhihou Liang;Julie Blanchard;Chun-Ling Dai

  • Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets

    Joshua F. Alfaro;Cheng Xin Gong;Matthew E. Monroe;Joshua T. Aldrich

  • Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease.

    Yanqiu Deng;Yanqiu Deng;Bin Li;Ying Liu;Khalid Iqbal

Frequent Co-Authors

Inge Grundke-Iqbal
Inge Grundke-Iqbal University of York
Khalid Iqbal
Khalid Iqbal University of York
Youming Lu
Youming Lu Huazhong University of Science and Technology
Heiko Braak
Heiko Braak University of Ulm

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