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Molecular Biology

D-Index
51
Citations
19473
World Ranking
2465
National Ranking
1214

Overview

Robert K. Bradley is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with additional focus on Medicine. Within these domains, their work emphasizes subfields such as Molecular Biology, Hematology, Immunology, Oncology, and Cancer Research.

The scientist's recent publications highlight significant contributions related to RNA splicing and cancer. Notable papers include:

  • RNA splicing dysregulation and the hallmarks of cancer (2023, Nature reviews. Cancer)
  • Pharmacologic modulation of RNA splicing enhances anti-tumor immunity (2021, Cell)
  • Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer (2020, Cancer Cell)
  • RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons (2020, Nature Genetics)
  • Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome (2021, Cell Reports)

The topics frequently addressed in their research include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Acute Myeloid Leukemia Research
  • Cancer Genomics and Diagnostics
  • CRISPR and Genetic Engineering
  • Epigenetics and DNA Methylation

Frequent co-authors collaborating with Robert K. Bradley are:

  • Omar Abdel-Wahab
  • Austin M. Gabel
  • Jose Mario Bello Pineda
  • James D. Thomas
  • Eric Wang

Their research outputs have appeared in multiple publication venues, with recurring appearances in:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Cancer Research
  • Blood Cancer Discovery

Robert K. Bradley's work entails an extensive focus on the molecular mechanics of RNA, particularly its role in cancer biology, including how RNA splicing impacts oncogenic processes and tumor immunity. The breadth of their studies encompasses both fundamental biochemical mechanisms and applied medical research, contributing to understanding genetic regulation and cancer pathology on multiple levels.

Best Publications

  • Integrative clinical genomics of advanced prostate cancer

    Dan Robinson;Eliezer M. Van Allen;Eliezer M. Van Allen;Yi Mi Wu;Nikolaus Schultz

  • The Molecular Taxonomy of Primary Prostate Cancer

    Adam Abeshouse;Jaeil Ahn;Rehan Akbani;Adrian Ally

  • Evolution of genes and genomes on the Drosophila phylogeny.

    Andrew G. Clark;Michael B. Eisen;Michael B. Eisen;Douglas R. Smith;Casey M. Bergman

  • Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment

    Carla A. Klattenhoff;Johanna C. Scheuermann;Lauren E. Surface;Robert K. Bradley

  • RNA splicing factors as oncoproteins and tumour suppressors

    Heidi Dvinge;Eunhee Kim;Omar Abdel-Wahab;Robert K. Bradley

  • SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

    Eunhee Kim;Janine O. Ilagan;Yang Liang;Gerrit M. Daubner

  • Erratum: Integrative Clinical Genomics of Advanced Prostate Cancer

    Dan Robinson;Eliezer M. Van Allen;Yi Mi Wu;Nikolaus Schultz

  • Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

    Stanley Chun-Wei Lee;Heidi Dvinge;Eunhee Kim;Hana Cho

  • Widespread intron retention diversifies most cancer transcriptomes

    Heidi Dvinge;Robert K. Bradley

  • U2AF1 mutations alter splice site recognition in hematological malignancies

    Janine O. Ilagan;Aravind Ramakrishnan;Aravind Ramakrishnan;Brian Hayes;Michele E. Murphy

  • Binding Site Turnover Produces Pervasive Quantitative Changes in Transcription Factor Binding between Closely Related Drosophila Species

    Robert K. Bradley;Xiao-Yong Li;Xiao-Yong Li;Cole Trapnell;Stuart Davidson

  • Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

    Sydney X. Lu;Emma De Neef;Emma De Neef;James D. Thomas;Erich Sabio;Erich Sabio

  • Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

    Stanley Chun-Wei Lee;Khrystyna North;Eunhee Kim;Eunjung Jang

  • Spliceosomal disruption of the non-canonical BAF complex in cancer.

    Daichi Inoue;Daichi Inoue;Guo-Liang Chew;Bo Liu;Brittany C. Michel;Brittany C. Michel

  • Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

    Akihide Yoshimi;Kuan Ting Lin;Daniel H. Wiseman;Mohammad Alinoor Rahman

  • Massive Mitochondrial Gene Transfer in a Parasitic Flowering Plant Clade

    Zhenxiang Xi;Yuguo Wang;Robert K. Bradley;M. Sugumaran

  • Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

    Christopher G. Hubert;Robert K. Bradley;Yu Ding;Chad M. Toledo

  • RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

    Heidi Dvinge;Jamie Guenthoer;Peggy L. Porter;Robert K. Bradley

  • Alternative Splicing of RNA Triplets Is Often Regulated and Accelerates Proteome Evolution

    Robert K. Bradley;Jason Merkin;Nicole J. Lambert;Christopher B. Burge

  • Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

    Luisa F. Escobar-Hoyos;Alex Penson;Ram Kannan;Hana Cho

Frequent Co-Authors

Omar Abdel-Wahab
Omar Abdel-Wahab Memorial Sloan Kettering Cancer Center
Harold E. Varmus
Harold E. Varmus Cornell University
Peter S. Nelson
Peter S. Nelson Fred Hutchinson Cancer Research Center
Stephen R. Plymate
Stephen R. Plymate University of Washington
Peter Smith
Peter Smith University of Aberdeen
Francesca Demichelis
Francesca Demichelis University of Trento
Eliezer M. Van Allen
Eliezer M. Van Allen Harvard University
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Andrea Sboner
Andrea Sboner Cornell University
Jianjiong Gao
Jianjiong Gao Memorial Sloan Kettering Cancer Center

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