RNA, Transfer RNA, Biochemistry, Genetics and Methylation are his primary areas of study. His RNA research integrates issues from RNA methylation, Computational biology and Nucleotide. His research integrates issues of Protein biosynthesis, Base pair, Stereochemistry and Enzyme in his study of Transfer RNA.
His Methylation research includes elements of RNA-binding protein, Drosophila Protein and DNA methylation. His work deals with themes such as TRNA methyltransferase activity and TRNA Methyltransferase, which intersect with DNA methylation. His research investigates the connection between TRNA methylation and topics such as Molecular biology that intersect with problems in Post-transcriptional modification.
His primary scientific interests are in RNA, Transfer RNA, Biochemistry, Methylation and Genetics. Mark Helm combines subjects such as Nucleotide, DNA, Molecular biology, Cell biology and Computational biology with his study of RNA. His Molecular biology research is multidisciplinary, incorporating elements of Transcription and Mitochondrial DNA.
The Computational biology study combines topics in areas such as Epitranscriptomics and 2'-O-methylation. Mark Helm works mostly in the field of Transfer RNA, limiting it down to topics relating to Ribosomal RNA and, in certain cases, Small nucleolar RNA, as a part of the same area of interest. His Methylation study integrates concerns from other disciplines, such as Translation and DNA methylation.
Mark Helm spends much of his time researching RNA, Transfer RNA, Cell biology, Computational biology and Nucleotide. RNA is a primary field of his research addressed under Biochemistry. His Transfer RNA research is multidisciplinary, relying on both 2'-O-methylation, Methylation and Enzyme.
His Cell biology research is multidisciplinary, incorporating elements of Gene expression, DNA methylation, TLR7, Innate immune system and Binding site. The Computational biology study combines topics in areas such as Reference genome, Deep sequencing, Epitranscriptomics, Microscale thermophoresis and Sequence analysis. Mark Helm combines subjects such as Molecular biology, Manganese and DNA polymerase with his study of Nucleotide.
Mark Helm mainly focuses on RNA, Transfer RNA, Cell biology, Enzyme and Computational biology. His study of Uridine is a part of RNA. His study in Transfer RNA is interdisciplinary in nature, drawing from both Complementary DNA, Non-coding RNA, Polymerase and Methylation.
His Cell biology research includes themes of Transcriptome, TLR7, Innate immune system and DNA methylation. His Enzyme research entails a greater understanding of Biochemistry. Mark Helm has included themes like Microscale thermophoresis, Ribosomal RNA, RNA modification and Tissue Differentiation in his Computational biology study.
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MODOMICS: a database of RNA modification pathways—2013 update
Magdalena A. Machnicka;Kaja Milanowska;Okan Osman Oglou;Elzbieta Purta.
Nucleic Acids Research (2012)
MODOMICS: a database of RNA modification pathways. 2017 update.
Pietro Boccaletto;Magdalena A Machnicka;Magdalena A Machnicka;Elzbieta Purta;Pawel Piatkowski.
Nucleic Acids Research (2018)
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
Matthias Schaefer;Tim Pollex;Katharina Hanna;Francesca Tuorto.
Genes & Development (2010)
Post-transcriptional nucleotide modification and alternative folding of RNA.
Nucleic Acids Research (2006)
tRNA stabilization by modified nucleotides.
Yuri Motorin;Mark Helm.
RNA nucleotide methylation
Yuri Motorin;Mark Helm.
Wiley Interdisciplinary Reviews - Rna (2011)
Search for characteristic structural features of mammalian mitochondrial tRNAs.
Mark Helm;Hervé Brulé;Dagmar Friede;Richard Giegé.
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.
Francesca Tuorto;Reinhard Liebers;Tanja Musch;Matthias Schaefer.
Nature Structural & Molecular Biology (2012)
Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders
Sandra Blanco;Sabine Dietmann;Joana V Flores;Shobbir Hussain.
The EMBO Journal (2014)
Detecting RNA modifications in the epitranscriptome: predict and validate
Mark Helm;Yuri Motorin.
Nature Reviews Genetics (2017)
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