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Biology and Biochemistry

D-Index
68
Citations
20178
World Ranking
7688
National Ranking
561

Overview

Mark Helm is affiliated with Johannes Gutenberg University of Mainz in Germany and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology with a particular focus on Molecular Biology. Their work addresses core aspects of RNA biology and cancer research.

Their research covers several key topics including:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • Cancer-related molecular mechanisms research
  • Cancer-related gene regulation
  • Epigenetics and DNA methylation
  • Genomics and phylogenetic studies

Mark Helm's frequent coauthors include Yuri Motorin, Virginie Marchand, Susanne Gerber, Kristina Friedland, and Larissa Bessler, indicating collaborative efforts in RNA-related molecular studies.

The most common venues for their publications are:

  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • RNA
  • Angewandte Chemie International Edition

Among their recent papers are:

  • RNA modifications in physiology and disease: towards clinical applications, 2023, Nature Reviews Genetics
  • Hakai is required for stabilization of core components of the m6A mRNA methylation machinery, 2021, Nature Communications
  • HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA, 2020, Nucleic Acids Research
  • METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer, 2023, Molecular Cancer
  • Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs, 2021, Molecular Cell

Best Publications

  • MODOMICS: a database of RNA modification pathways. 2017 update.

    Boccaletto P;Machnicka Ma;Machnicka Ma;Purta E;Piatkowski P

  • MODOMICS: a database of RNA modification pathways—2013 update

    Magdalena A. Machnicka;Kaja Milanowska;Okan Osman Oglou;Elzbieta Purta

  • RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

    Matthias Schaefer;Tim Pollex;Katharina Hanna;Francesca Tuorto

  • Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders

    Sandra Blanco;Sabine Dietmann;Joana V Flores;Shobbir Hussain

  • RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

    Francesca Tuorto;Reinhard Liebers;Tanja Musch;Matthias Schaefer

  • Detecting RNA modifications in the epitranscriptome: predict and validate

    Mark Helm;Yuri Motorin

  • m 6 A modulates neuronal functions and sex determination in Drosophila

    Tina Lence;Junaid Akhtar;Marc Bayer;Katharina Schmid

  • Post-transcriptional nucleotide modification and alternative folding of RNA.

    Mark Helm

  • tRNA stabilization by modified nucleotides.

    Yuri Motorin;Mark Helm

  • Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.

    Philip Knuckles;Tina Lence;Irmgard U. Haussmann;Dominik Jacob

  • RNA nucleotide methylation

    Yuri Motorin;Mark Helm

  • Search for characteristic structural features of mammalian mitochondrial tRNAs.

    Mark Helm;Hervé Brulé;Dagmar Friede;Richard Giegé

  • 5-methylcytosine in RNA: detection, enzymatic formation and biological functions.

    Yuri Motorin;Frank Lyko;Mark Helm

  • A Watson-Crick base-pair-disrupting methyl group (m1A9) is sufficient for cloverleaf folding of human mitochondrial tRNALys.

    Mark Helm;Richard Giegé;Catherine Florentz

  • The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA

    Mark Helm;Hervé Brulé;Hervé Brulé;Françoise Degoul;Claude Cepanec

  • Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland.

    Mark Helm;Juan D. Alfonzo

  • Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.

    Tomasz P. Jurkowski;Madeleine Meusburger;Sameer Phalke;Mark Helm

  • Illumina-based RiboMethSeq approach for mapping of 2′-O-Me residues in RNA

    Virginie Marchand;Florence Blanloeil-Oillo;Mark Helm;Yuri Motorin

  • Pseudouridine: Still mysterious, but never a fake (uridine)!

    Felix Spenkuch;Yuri Motorin;Mark Helm

  • Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation

    Albert Jeltsch;Ann Ehrenhofer-Murray;Tomasz P. Jurkowski;Frank Lyko

Frequent Co-Authors

G. Ulrich Nienhaus
G. Ulrich Nienhaus Karlsruhe Institute of Technology
Catherine Florentz
Catherine Florentz University of Strasbourg
Frank Lyko
Frank Lyko German Cancer Research Center
Richard Giegé
Richard Giegé Centre national de la recherche scientifique, CNRS
Alexander H. Dalpke
Alexander H. Dalpke Heidelberg University
Kaloian Koynov
Kaloian Koynov Max Planck Institute for Polymer Research
Christoph Dieterich
Christoph Dieterich University Hospital Heidelberg
Volker Mailänder
Volker Mailänder Max Planck Society
Hans-Jürgen Butt
Hans-Jürgen Butt Max Planck Society
Holger Frey
Holger Frey Johannes Gutenberg University of Mainz

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