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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
14316
World Ranking
10218
National Ranking
4461

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Eric M. Phizicky is affiliated with the University of Rochester in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology within these broader fields.

The scientist's work encompasses several main topics, including:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • Peptidase inhibition and analysis
  • Cancer-related gene regulation
  • Protein structure and dynamics
  • Enzyme structure and function

Phizicky has contributed to a number of recent publications. Notable papers include:

  • "The life and times of a tRNA," 2023, RNA
  • "Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences," 2020, PLoS Genetics
  • "Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species," 2022, PLoS Genetics
  • "A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay," 2024, PLoS Genetics
  • "Identification of a Trm732 Motif Required for 2'- O -methylation of the tRNA Anticodon Loop by Trm7," 2022, ACS Omega

The frequent coauthors who have appeared alongside Phizicky in publications include:

  • Erin Marcus
  • Thareendra De Zoysa
  • Justin C. Fay
  • Monika Tasak
  • Alayna C. Hauke

Phizicky's work has been published repeatedly in certain venues, reflecting a focus on specific journals and repositories:

  • bioRxiv (Cold Spring Harbor Laboratory), 5 publications
  • PLoS Genetics, 3 publications
  • RNA, 2 publications
  • The FASEB Journal, 2 publications
  • ACS Omega, 1 publication

In recognition of contributions to the scientific community, Phizicky was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Protein-protein interactions: methods for detection and analysis.

    E M Phizicky;S Fields

  • Protein analysis on a proteomic scale.

    Eric Phizicky;Philippe I. H. Bastiaens;Heng Zhu;Michael Snyder

  • tRNA biology charges to the front

    Eric M. Phizicky;Anita K. Hopper

  • Biochemical and genetic analysis of the yeast proteome with a movable ORF collection

    Daniel M. Gelperin;Michael A. White;Martha L. Wilkinson;Yoshiko Kon

  • A biochemical genomics approach for identifying genes by the activity of their products.

    Mark R. Martzen;Stephen M. McCraith;Sherry L. Spinelli;Francy M. Torres

  • Rapid tRNA Decay Can Result from Lack of Nonessential Modifications

    Andrei Alexandrov;Irina Chernyakov;Weifeng Gu;Shawna L. Hiley

  • ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

    Aaron E Cozen;Erin Quartley;Andrew D Holmes;Eva Hrabeta-Robinson

  • tRNA transfers to the limelight.

    Anita K. Hopper;Eric M. Phizicky

  • Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA

    Andrei Alexandrov;Mark R. Martzen;Eric M. Phizicky

  • Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5′–3′ exonucleases Rat1 and Xrn1

    Irina Chernyakov;Joseph M. Whipple;Lakmal Kotelawala;Elizabeth J. Grayhack

  • Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation

    Cristina Pop;Silvi Rouskin;Nicholas T Ingolia;Lu Han

  • Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9.

    Jane E. Jackman;Rebecca K. Montange;Harmit S. Malik;Eric M. Phizicky

  • Saccharomyces cerevisiae tRNA ligase. Purification of the protein and isolation of the structural gene.

    E M Phizicky;R C Schwartz;J Abelson

  • Induction of SOS functions: Regulation of proteolytic activity of E. coil RecA protein by interaction with DNA and nucleoside triphosphate

    Eric M. Phizicky;Jeffrey W. Roberts

  • Do all modifications benefit all tRNAs

    Eric M. Phizicky;Juan D. Alfonzo

  • Activity of the Escherichia coli recA-gene product.

    J. W. Roberts;C. W. Roberts;N. L. Craig;E. M. Phizicky

  • tRNAs Marked with CCACCA Are Targeted for Degradation

    Jeremy E. Wilusz;Joseph M. Whipple;Eric M. Phizicky;Phillip A. Sharp

  • The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA

    Joseph M. Whipple;Elizabeth A. Lane;Irina Chernyakov;Sonia D'Silva

  • Mutation in WDR4 impairs tRNA m7G46 methylation and causes a distinct form of microcephalic primordial dwarfism

    Ranad Shaheen;Ghada M H Abdel-Salam;Michael P. Guy;Michael P. Guy;Rana Alomar

  • tRNAs Marked with CCACCA Are Targeted for Degradation

    J. M. Whipple;E. M. Phizicky;Jeremy Wilusz;Phillip A. Sharp

Frequent Co-Authors

Stanley Fields
Stanley Fields University of Washington
Fowzan S. Alkuraya
Fowzan S. Alkuraya Alfaisal University
Anita K. Hopper
Anita K. Hopper The Ohio State University
Douglas H. Turner
Douglas H. Turner University of Rochester
Wim G. J. Hol
Wim G. J. Hol University of Washington
Jeffrey W. Roberts
Jeffrey W. Roberts Cornell University
Ranad Shaheen
Ranad Shaheen King Faisal Specialist Hospital & Research Centre
Todd M. Lowe
Todd M. Lowe University of California, Santa Cruz
David J. Galas
David J. Galas Pacific Northwest Diabetes Research Institute
John Abelson
John Abelson University of California, San Francisco

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