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Chemistry

D-Index
108
Citations
40024
World Ranking
876
National Ranking
348

Biology and Biochemistry

D-Index
110
Citations
41261
World Ranking
973
National Ranking
599

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1992 - Royal Netherlands Academy of Arts and Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Wim G. J. Hol is a researcher affiliated with the University of Washington in the United States. Their scholarly work spans various areas within Biochemistry, Genetics, and Molecular Biology, with particular focus on Molecular Biology, Epidemiology, Endocrinology, and Genetics.

The research topics addressed by Hol include:

  • RNA and protein synthesis mechanisms
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Biochemical and Molecular Research
  • Vibrio bacteria research studies
  • Bacterial Genetics and Biotechnology
  • CRISPR and Genetic Engineering

Hol's publications appear in several scientific venues, demonstrating contributions to multiple fields. Frequent publication venues include:

  • RSC Medicinal Chemistry
  • mSphere
  • Acta Crystallographica Section D Structural Biology

Recent papers authored or coauthored by Hol cover a range of biological and biochemical subjects:

  • Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei, 2020, RSC Medicinal Chemistry
  • Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease, 2020, mSphere
  • Jan Drenth (1925-2025), 2025, Acta Crystallographica Section D Structural Biology

Hol has collaborated with several researchers across these topics and publications, with frequent coauthors including Zhongsheng Zhang, Ximena Barros-Álvarez, J. Robert Gillespie, Ranae M. Ranade, and Wenlin Huang.

Hol's career is marked by recognition from scientific communities and academies. Honors include:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2013
  • Royal Netherlands Academy of Arts and Sciences, 1992
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Prediction of the Occurrence of the ADP-binding βαβ-fold in Proteins, Using an Amino Acid Sequence Fingerprint

    Rik K. Wierenga;Peter Terpstra;Wim G.J. Hol

  • ALPHA-HELIX DIPOLE AND PROPERTIES OF PROTEINS

    W. G. J. Hol;P. T. van Duijnen;H. J. C. Berendsen

  • Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

    Matthew R. Redinbo;Lance Stewart;Peter Kuhn;James J. Champoux

  • A model for the mechanism of human topoisomerase I.

    Lance Stewart;Matthew R. Redinbo;Xiayang Qiu;Wim G. J. Hol

  • A general protocol for the generation of Nanobodies for structural biology

    Els Pardon;Toon Laeremans;Sarah Triest;Søren G F Rasmussen

  • Crystal structure of cholera toxin B‐pentamer bound to receptor GM1 pentasaccharide

    E. A. Merritt;S. Sarfaty;F. van den Akker;C. L'Hoir

  • The role of the α-helix dipole in protein function and structure

    Wim G.J. Hol

  • Crystal Structure of a Cholera Toxin-Related Heat-Labile Enterotoxin from E. coli

    Titia K. Sixma;Sylvia E. Pronk;Kor H. Kalk;Ellen S. Wartna

  • The type II secretion system: biogenesis, molecular architecture and mechanism.

    Konstantin V. Korotkov;Maria Sandkvist;Wim G. J. Hol

  • Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution.

    Anne Volbeda;Wim G.J. Hol

  • Structure of Bovine Pancreatic Phospholipase A2 at 1.7Å Resolution

    Bauke W. Dijkstra;Kor H. Kalk;Wim G.J. Hol;Jan Drenth

  • Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences

    Karen A. Magnus;Bart Hazes;Hoa Ton‐That;Celia Bonaventura

  • Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant

    Rik K. Wierenga;Wim G. J. Hol

  • 3.2 Å structure of the copper-containing, oxygen-carrying protein Panulirus interruptus haemocyanin

    W. P. J. Gaykema;W. G. J. Hol;J. M. Vereijken;N. M. Soeter

  • The covalent and tertiary structure of bovine liver rhodanese.

    Jan H. Ploegman;Gé Drent;Kor H. Kalk;Wim G. J. Hol

  • Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation.

    B Hazes;K.A Magnus;C Bonaventura;J Bonaventura

  • Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

    Tk Sixma;Kh Kalk;Bam Vanzanten;Z Dauter

  • THE INTACT AND CLEAVED HUMAN ANTITHROMBIN-III COMPLEX AS A MODEL FOR SERPIN-PROTEINASE INTERACTIONS

    H A Schreuder;B de Boer;R Dijkema;J Mulders

  • The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

    Sergio E. Martinez;Albert Y. Wu;Natalie A. Glavas;Xiao-Bo Tang

  • Structure-based drug design: progress, results and challenges

    Christophe Lmj Verlinde;Wim Gj Hol

Frequent Co-Authors

Christophe L. M. J. Verlinde
Christophe L. M. J. Verlinde University of Washington
Ethan A. Merritt
Ethan A. Merritt University of Washington
Frederick S. Buckner
Frederick S. Buckner University of Washington
Kor H. Kalk
Kor H. Kalk University of Groningen
Wesley C. Van Voorhis
Wesley C. Van Voorhis University of Washington
Randall K. Holmes
Randall K. Holmes University of Colorado Denver
Michael H. Gelb
Michael H. Gelb University of Washington
Paul A. M. Michels
Paul A. M. Michels University of Edinburgh
James J. Champoux
James J. Champoux University of Washington
Titia K. Sixma
Titia K. Sixma Antoni van Leeuwenhoek Hospital

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