James J. Champoux

Research.com Recognitions

• 2017 - Fellow of the American Association for the Advancement of Science (AAAS)
• 1980 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Best Publications

• DNA topoisomerases: structure, function, and mechanism.

  James J. Champoux

  3860
  Citations

• Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

  Matthew R. Redinbo;Lance Stewart;Peter Kuhn;James J. Champoux

  1166
  Citations

• A model for the mechanism of human topoisomerase I.

  Lance Stewart;Matthew R. Redinbo;Xiayang Qiu;Wim G. J. Hol

  914
  Citations

• DNA topoisomerase I is involved in both repression and activation of transcription

  Alejandro Merino;Knut R. Madden;William S. Lane;James J. Champoux

  523
  Citations

• An Activity from Mammalian Cells That Untwists Superhelical DNA—A Possible Swivel For DNA Replication

  James J. Champoux;Renato Dulbecco

  403
  Citations

• The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

  Heidrun Interthal;Jeffrey J. Pouliot;James J. Champoux

  378
  Citations

• Human DNA topoisomerase I: relaxation, roles, and damage control.

  John B. Leppard;James J. Champoux

  299
  Citations

• Deletions affecting the transposition of an antibiotic resistance gene.

  Fred Heffron;Pat Bedinger;James J. Champoux;Stanley Falkow

  290
  Citations

• Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages

  Heidrun Interthal;Hong Jing Chen;James J. Champoux

  285
  Citations

• Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA

  Michael D. Been;Richard R. Burgess;James J. Champoux

  272
  Citations

• SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.

  Heidrun Interthal;Hong Jing Chen;Thomas E Kehl-Fie;Jörg Zotzmann

  268
  Citations

• Proteins that affect DNA conformation.

  James J. Champoux

  257
  Citations

• The Domain Organization of Human Topoisomerase I

  Lance Stewart;Gregory C. Ireton;James J. Champoux

  244
  Citations

• The Crystal Structure of Human Tyrosyl-DNA Phosphodiesterase, Tdp1

  Douglas R Davies;Heidrun Interthal;James J Champoux;Wim G.J Hol

  216
  Citations

• Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.

  Matthew R. Redinbo;James J. Champoux;Wim G J Hol

  210
  Citations

• Biochemical and Biophysical Analyses of Recombinant Forms of Human Topoisomerase I

  Lance Stewart;Gregory C. Ireton;Leon H. Parker;Knut R. Madden

  201
  Citations

• RNase H activity: Structure, specificity, and function in reverse transcription

  Sharon J. Schultz;James J. Champoux

  185
  Citations

• Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNA.

  James J. Champoux

  183
  Citations

• Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin.

  Knut R. Madden;James J. Champoux

  176
  Citations

• The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

  Stephaie E. Porter;James J. Champoux

  175
  Citations