James J. Champoux

James J. Champoux publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where James J. Champoux sits on this spectrum.

James J. Champoux D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where James J. Champoux sits on this spectrum.

Research.com Recognitions

• 2017 - Fellow of the American Association for the Advancement of Science (AAAS)
• 1980 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Best Publications

• DNA topoisomerases: structure, function, and mechanism.

  James J. Champoux

  3860
  Citations

• Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

  Matthew R. Redinbo;Lance Stewart;Peter Kuhn;James J. Champoux

  1166
  Citations

• A model for the mechanism of human topoisomerase I.

  Lance Stewart;Matthew R. Redinbo;Xiayang Qiu;Wim G. J. Hol

  914
  Citations

• DNA topoisomerase I is involved in both repression and activation of transcription

  Alejandro Merino;Knut R. Madden;William S. Lane;James J. Champoux

  523
  Citations

• An Activity from Mammalian Cells That Untwists Superhelical DNA—A Possible Swivel For DNA Replication

  James J. Champoux;Renato Dulbecco

  403
  Citations

• The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

  Heidrun Interthal;Jeffrey J. Pouliot;James J. Champoux

  378
  Citations

• Human DNA topoisomerase I: relaxation, roles, and damage control.

  John B. Leppard;James J. Champoux

  299
  Citations

• Deletions affecting the transposition of an antibiotic resistance gene.

  Fred Heffron;Pat Bedinger;James J. Champoux;Stanley Falkow

  290
  Citations

• Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages

  Heidrun Interthal;Hong Jing Chen;James J. Champoux

  285
  Citations

• Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA

  Michael D. Been;Richard R. Burgess;James J. Champoux

  272
  Citations

• SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.

  Heidrun Interthal;Hong Jing Chen;Thomas E Kehl-Fie;Jörg Zotzmann

  268
  Citations

• Proteins that affect DNA conformation.

  James J. Champoux

  257
  Citations

• The Domain Organization of Human Topoisomerase I

  Lance Stewart;Gregory C. Ireton;James J. Champoux

  244
  Citations

• The Crystal Structure of Human Tyrosyl-DNA Phosphodiesterase, Tdp1

  Douglas R Davies;Heidrun Interthal;James J Champoux;Wim G.J Hol

  216
  Citations

• Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.

  Matthew R. Redinbo;James J. Champoux;Wim G J Hol

  210
  Citations

• Biochemical and Biophysical Analyses of Recombinant Forms of Human Topoisomerase I

  Lance Stewart;Gregory C. Ireton;Leon H. Parker;Knut R. Madden

  201
  Citations

• RNase H activity: Structure, specificity, and function in reverse transcription

  Sharon J. Schultz;James J. Champoux

  185
  Citations

• Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNA.

  James J. Champoux

  183
  Citations

• Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin.

  Knut R. Madden;James J. Champoux

  176
  Citations

• The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

  Stephaie E. Porter;James J. Champoux

  175
  Citations