Glenda Kohlhagen

Overview

Best Publications

• Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA

  Myoung Sook Kim;Mellissa Blake;Jin Hyen Baek;Glenda Kohlhagen

  664
  Citations

• DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.

  Yves Pommier;Glenda Kohlhagen;Christian Bailly;Michael Waring

  436
  Citations

• Repair of and checkpoint response to topoisomerase I-mediated DNA damage.

  Yves Pommier;Christophe Redon;V.Ashutosh Rao;Jennifer A Seiler

  390
  Citations

• Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.

  Mariafiorella Brangi;Thomas Litman;Marco Ciotti;Kenryu Nishiyama

  342
  Citations

• Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol

  Bernard W. Parker;Gurmeet Kaur;Wilberto Nieves-Neira;Mohammed Taimi

  335
  Citations

• Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors

  Yves Pommier;D. Pharm;Mark R. Fesen;Akira Fujimori

  289
  Citations

• EFFECTS OF URACIL INCORPORATION, DNA MISMATCHES, AND ABASIC SITES ON CLEAVAGE AND RELIGATION ACTIVITIES OF MAMMALIAN TOPOISOMERASE I

  Philippe Pourquier;Li-Ming Ueng;Glenda Kohlhagen;Abhijit Mazumder

  287
  Citations

• Human mitochondrial topoisomerase I.

  Hongliang Zhang;Juana M. Barceló;Benson Lee;Glenda Kohlhagen

  253
  Citations

• Trapping of Mammalian Topoisomerase I and Recombinations Induced by Damaged DNA Containing Nicks or Gaps: IMPORTANCE OF DNA END PHOSPHORYLATION AND CAMPTOTHECIN EFFECTS *

  Philippe Pourquier;André A. Pilon;Glenda Kohlhagen;Abhijit Mazumder

  247
  Citations

• Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions.

  Isabelle Plo;Zhi Yong Liao;Juana M Barceló;Glenda Kohlhagen

  238
  Citations

• The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.

  David Bom;Dennis P. Curran;Stefan Kruszewski;Stephen G. Zimmer

  228
  Citations

• Mutation at the Catalytic Site of Topoisomerase I in CEM/C2, a Human Leukemia Cell Line Resistant to Camptothecin

  Fujimori A;Harker Wg;Kohlhagen G;Hoki Y

  217
  Citations

• Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites

  Yves Pommier;Glenda Kohlhagen;Kurt W. Kohn;Francois Leteurtre

  201
  Citations

• Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives

  Akihiko Tanizawa;Kurt W. Kohn;Glenda Kohlhagen;Francois Leteurtre

  171
  Citations

• Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase.

  Laurent Debéthune;Glenda Kohlhagen;Anna Grandas;Yves Pommier

  168
  Citations

• Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells.

  Philippe Pourquier;Yuji Takebayashi;Yoshimasa Urasaki;Christopher Gioffre

  153
  Citations

• Characterization of a Novel Topoisomerase I Mutation from a Camptothecin-resistant Human Prostate Cancer Cell Line

  Yoshimasa Urasaki;Gary S. Laco;Phillipe Pourquier;Yuji Takebayashi

  143
  Citations

• Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine), an Antimetabolite That Poisons Topoisomerase I

  Philippe Pourquier;Christopher Gioffre;Glenda Kohlhagen;Yoshimasa Urasaki

  138
  Citations

• Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove.

  Yuji Takebayashi;Philippe Pourquier;Akira Yoshida;Glenda Kohlhagen

  134
  Citations

• Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.

  A Tanizawa;R Beitrand;G Kohlhagen;A Tabuchi

  126
  Citations