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Giovanni Capranico

Giovanni Capranico

D-Index & Metrics

Molecular Biology

D-Index
57
Citations
9030
World Ranking
2166
National Ranking
48

Overview

Giovanni Capranico is affiliated with the University of Bologna in Italy and specializes in Biochemistry, Genetics and Molecular Biology. Their research largely focuses on Molecular Biology, with notable work in Oncology, Immunology, Neurology, and Genetics as subfields.

Their main research topics include:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • RNA and protein synthesis mechanisms
  • Cancer therapeutics and mechanisms
  • Lung Cancer Research Studies
  • Interferon and immune responses

Giovanni Capranico has contributed to several recent publications. Selected papers include:

  • "G-quadruplex-R-loop interactions and the mechanism of anticancer G-quadruplex binders" (2020), published in Nucleic Acids Research
  • "G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells" (2021), published in Nucleic Acids Research
  • "Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells" (2020), published in Journal of Medicinal Chemistry
  • "Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway" (2022), published in British Journal of Cancer
  • "Non-B DNA structures as a booster of genome instability" (2023), published in Biochimie

Frequent co-authors in their work include:

  • Marco Russo
  • Giulia Miglietta
  • Jessica Marinello
  • Renée C. Duardo
  • Simona Pepe

Their research has appeared repeatedly in key journals, particularly:

  • Nucleic Acids Research
  • Cell Reports
  • Biochimie
  • Journal of Medicinal Chemistry
  • British Journal of Cancer

Best Publications

  • Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development.

    Giovanni Capranico;Stella Tinelli;Caroline A. Austin;Mark L. Fisher

  • DNA topoisomerase II as the primary target of anti-tumor anthracyclines.

    F Zunino;G Capranico

  • Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.

    C Jaxel;G Capranico;D Kerrigan;K W Kohn

  • DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

    Alessio De Magis;Stefano G. Manzo;Marco Russo;Jessica Marinello

  • Anthracyclines: selected new developments.

    M. Binaschi;M. Bigioni;A. Cipollone;C. Rossi

  • Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

    Giovanni Capranico;Kurt W. Kohn;Yves Pommier

  • In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2.

    Francesca Fornari;Maddalena Milazzo;Pasquale Chieco;Massimo Negrini

  • Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives.

    Jessica Marinello;Maria Delcuratolo;Giovanni Capranico

  • Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

    Giovanni Capranico;Franco Zunino;Kurt W. Kohn;Yves Pommier

  • Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide

    Yves Pommier;Giovanni Capranico;Ann Orr;Kurt W. Kohn

  • Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.

    K Wassermann;J Markovits;C Jaxel;G Capranico

  • Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.

    Giuseppe Giaccone;Adi F. Gazdar;Hans Beck;Franco Zunino

  • DNA sequence selectivity of topoisomerases and topoisomerase poisons

    Giovanni Capranico;Monica Binaschi

  • Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors.

    Rosanna Filosa;Antonella Peduto;Simone Di Micco;Paolo de Caprariis

  • New developments in antitumor anthracyclines

    Federico Arcamone;Fabio Animati;Giovanni Capranico;Paolo Lombardi

  • Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

    Stefano Giustino Manzo;Zhao-Li Zhou;Ying-Qing Wang;Jessica Marinello

  • DNA Topoisomerase I differentially modulates R-loops across the human genome.

    Stefano G. Manzo;Stefano G. Manzo;Stella R. Hartono;Lionel A. Sanz;Jessica Marinello

  • A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons

    Giovanni Capranico;Monica Binaschi;M.Evelina Borgnetto;Franco Zunino

  • Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.

    Agnese Cristini;Giulia Ricci;Sébastien Britton;Simona Salimbeni;Simona Salimbeni

  • Characterization of novel antisense HIF-1α transcripts in human cancers

    Davide Bertozzi;Raffaella Iurlaro;Olivier Sordet;Jessica Marinello

Frequent Co-Authors

Franco Zunino
Franco Zunino University of Milan
Rosanna Supino
Rosanna Supino University of Milan
Yves Pommier
Yves Pommier National Institutes of Health
Kurt W. Kohn
Kurt W. Kohn National Institutes of Health
Giuseppe Giaccone
Giuseppe Giaccone Cornell University
Stefano Moro
Stefano Moro University of Padua
Ettore Novellino
Ettore Novellino University of Naples Federico II
Antonio Randazzo
Antonio Randazzo University of Naples Federico II
Davide Bertozzi
Davide Bertozzi University of Ferrara
Saverio Minucci
Saverio Minucci European Institute of Oncology

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