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Paola Perego

Paola Perego

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
13779
World Ranking
11895
National Ranking
348

Overview

Paola Perego is affiliated with the University of Milan in Italy. Their research output spans multiple areas within biochemistry, genetics, molecular biology, and medicine. The scientist's work focuses on several specialized subfields including molecular biology, oncology, cancer research, organic chemistry, and cell biology.

Key topics covered in their research include:

  • Ubiquitin and proteasome pathways
  • Histone deacetylase inhibitors research
  • Cancer, lipids, and metabolism
  • Cancer-related molecular pathways
  • Cancer, hypoxia, and metabolism
  • Advanced biosensing and bioanalysis techniques
  • Metal complexes synthesis and properties

Paola Perego has contributed to scholarly publications in several prominent venues, with multiple works appearing in:

  • Current Medicinal Chemistry
  • Frontiers in Cell and Developmental Biology
  • International Journal of Molecular Sciences
  • Cancer Research
  • Cancers

The scientist's recent publications include:

  • The rediscovery of platinum-based cancer therapy, 2020, Nature Reviews. Cancer
  • The mTOR/4E-BP1/eIF4E Signalling Pathway as a Source of Cancer Drug Targets, 2022, Current Medicinal Chemistry
  • Synergistic Effect of Perampanel and Temozolomide in Human Glioma Cell Lines, 2021, Journal of Personalized Medicine
  • Curcumin and Related Compounds in Cancer Cells: New Avenues for Old Molecules, 2022, Frontiers in Pharmacology
  • Targeting of the Lipid Metabolism Impairs Resistance to BRAF Kinase Inhibitor in Melanoma, 2022, Frontiers in Cell and Developmental Biology

Frequent collaborators in Paola Perego's research include:

  • Cristina Corno
  • Giovanni Luca Beretta
  • Matteo Costantino
  • Luca Mirra
  • Elisabetta Corna

Best Publications

  • Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment.

    Giulia Bertolini;Luca Roz;Paola Perego;Monica Tortoreto

  • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.

    Giovanna Andreola;Licia Rivoltini;Chiara Castelli;Veronica Huber

  • Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer.

    Alessandro Leonetti;Sugandhi Sharma;Roberta Minari;Paola Perego

  • The rediscovery of platinum-based cancer therapy

    Sven Rottenberg;Carmen Disler;Paola Perego

  • Inhibition of proteasome deubiquitinating activity as a new cancer therapy

    Pádraig D'Arcy;Slavica Brnjic;Maria Hägg Olofsson;Mårten Fryknäs

  • Association between Cisplatin Resistance and Mutation of p53 Gene and Reduced Bax Expression in Ovarian Carcinoma Cell Systems

    Paola Perego;Monica Giarola;Sabina C. Righetti;Rosanna Supino

  • Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer.

    N. Zaffaroni;M. Pennati;G. Colella;P. Perego

  • A novel trinuclear platinum complex overcomes cisplatin resistance in an osteosarcoma cell system.

    Paola Perego;Claudia Caserini;Laura Gatti;Nives Carenini

  • A proteomic approach to cisplatin resistance in the cervix squamous cell carcinoma cell line A431.

    Annalisa Castagna;Paolo Antonioli;Hubert Astner;Malimoud Hamdan

  • p53 Gene Status and Response to Platinum/Paclitaxel-Based Chemotherapy in Advanced Ovarian Carcinoma

    Cinzia Lavarino;Silvana Pilotti;Maria Oggionni;Laura Gatti

  • In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems

    Simona Romanelli;Paola Perego;Graziella Pratesi;Nives Carenini

  • A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts

    G Pratesi;P Perego;D Polizzi;S C Righetti

  • Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity

    Sabrina Dallavalle;Anna Ferrari;Barbara Biasotti;Lucio Merlini

  • Molecular mechanisms controlling sensitivity to toxic metal ions in yeast.

    Paola Perego;Stephen B. Howell

  • Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.

    Elisabetta Vergani;Viviana Vallacchi;Simona Frigerio;Paola Deho

  • Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.

    Giacomo Buscemi;Paola Perego;Nives Carenini;Makoto Nakanishi

  • Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.

    F Facchetti;S Previdi;M Ballarini;S Minucci;S Minucci

  • Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin

    Giovanni Luca Beretta;Valentina Benedetti;Giacomo Cossa;Yehuda G.A. Assaraf

  • Ovarian cancer cisplatin-resistant cell lines: Multiple changes including collateral sensitivity to Taxol

    P Perego;S Romanelli;N Carenini;I Magnani

  • A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line.

    Paola Perego;Michelandrea De Cesare;Paola De Isabella;Nives Carenini

Frequent Co-Authors

Franco Zunino
Franco Zunino University of Milan
Nadia Zaffaroni
Nadia Zaffaroni University of Milan
Rosanna Supino
Rosanna Supino University of Milan
Domenico Delia
Domenico Delia University of Milan
Stig Linder
Stig Linder Linköping University
Licia Rivoltini
Licia Rivoltini Fondazione IRCCS Istituto Nazionale dei Tumori
Silvana Pilotti
Silvana Pilotti University of Milan
Gabriella Sozzi
Gabriella Sozzi University of Milan
Silvana Canevari
Silvana Canevari University of Milan
Nicholas Farrell
Nicholas Farrell Virginia Commonwealth University

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