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D-Index & Metrics

Chemistry

D-Index
76
Citations
17539
World Ranking
4329
National Ranking
1368

Overview

Nicholas Farrell is affiliated with Virginia Commonwealth University in the United States and specializes in Biochemistry, Genetics, and Molecular Biology. Their research primarily spans molecular biology, organic chemistry, and cell biology, with additional work in oncology and materials chemistry. The scientist's publications also reflect a notable focus on proteoglycans and glycosaminoglycans research, glycosylation and glycoproteins research, advanced biosensing and bioanalysis techniques, DNA and nucleic acid chemistry, RNA interference and gene delivery, click chemistry and applications, and carbohydrate chemistry and synthesis.

Frequent publication venues for Nicholas Farrell include:

  • Journal of Inorganic Biochemistry
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cambridge Structural Database

Their collaborations feature multiple frequent co-authors, highlighting ongoing research relationships within their field. Notable frequent collaborators include:

  • Erica J. Peterson
  • James D. Hampton
  • Jennifer E. Koblinski
  • Susan J. Berners-Price
  • Samantha J. Katner

Recent publications illustrate the range and focus of their scientific output, presenting studies on chemical and biochemical innovations. Selected recent papers include:

  • "Controlling Nuclease Degradation of Wireframe DNA Origami with Minor Groove Binders," 2022, ACS Nano
  • "Ru(II)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer," 2020, Dalton Transactions
  • "A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II)-Modified Triplex-Forming Oligonucleotides," 2021, Angewandte Chemie International Edition
  • "Platinum complexes act as shielding agents against virus infection," 2021, Chemical Communications
  • "Conformational Modulation of Iduronic Acid-Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound and Implications for Development of Antimetastatic Platinum Drugs," 2020, Angewandte Chemie International Edition

The scientist's work integrates molecular and chemical biology to explore nucleic acid chemistry and therapeutic applications, particularly in oncology and antiviral fields.

Best Publications

  • Transition Metal Complexes as Drugs and Chemotherapeutic Agents

    Nicholas Farrell

  • Platinum-based drugs in cancer therapy

    Lloyd R. Kelland;Nicholas P. Farrell

  • Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N-methylimidazole, thiazole and quinoline. Crystal and molecular structure of trans-dichlorobis (thiazole)platinum(II)

    Marijo Van Beusichem;Nicholas Farrell

  • Biomedical uses and applications of inorganic chemistry. An overview

    Nicholas Farrell

  • Molecular methods for assessment of non-covalent metallodrug–DNA interactions

    Andrew Kellett;Zara Molphy;Creina Slator;Vickie McKee;Vickie McKee

  • DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent.

    Viktor Brabec;Jana Kašpárková;Oldřich Vrána;Olga Nováková

  • Multi-platinum anti-cancer agents. Substitution-inert compounds for tumor selectivity and new targets.

    N. P. Farrell

  • Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.

    N Farrell;L R Kelland;J D Roberts;M Van Beusichem

  • BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin.

    C Manzotti;G Pratesi;E Menta;R Di Domenico

  • Cytostatic trans-platinum(II) complexes.

    Nicholas Farrell;Tam T. B. Ha;Jean Pierre Souchard;Franz L. Wimmer

  • Comparison of chemical reactivity, cytotoxicity, interstrand cross-linking and DNA sequence specificity of bis(platinum) complexes containing monodentate or bidentate coordination spheres with their monomeric analogues.

    Nicholas Farrell;Y. Qu;L. Feng;B. Van Houten

  • Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes

    Nicholas Farrell;Yun Qu;Miles P. Hacker

  • A Third Mode of DNA Binding: Phosphate Clamps by a Polynuclear Platinum Complex

    Seiji Komeda;Tinoush Moulaei;Kristen Kruger Woods;Masahiko Chikuma

  • Towards Antitumor Active trans-Platinum Compounds

    Sheena M. Aris;Nicholas P. Farrell

  • Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity.

    Maria G. Mendoza-Ferri;Christian G. Hartinger;Marco A. Mendoza;Michael Groessl

  • DNA Interstrand Cross-links of the Novel Antitumor Trinuclear Platinum Complex BBR3464 CONFORMATION, RECOGNITION BY HIGH MOBILITY GROUP DOMAIN PROTEINS, AND NUCLEOTIDE EXCISION REPAIR

    Jana Kasparkova;Jana Zehnulova;Nicholas Farrell;Viktor Brabec

  • Zinc metalloproteins as medicinal targets

    A. I. Anzellotti;N. P. Farrell

  • Polynuclear platinum drugs.

    Nicholas Farrell

  • A novel trinuclear platinum complex overcomes cisplatin resistance in an osteosarcoma cell system.

    Paola Perego;Claudia Caserini;Laura Gatti;Nives Carenini

  • Current status of structure-activity relationships of platinum anticancer drugs: activation of the trans geometry.

    Farrell N

Frequent Co-Authors

Viktor Brabec
Viktor Brabec Czech Academy of Sciences
Susan J. Berners-Price
Susan J. Berners-Price Griffith University
Jana Kasparkova
Jana Kasparkova Czech Academy of Sciences
John D. Roberts
John D. Roberts Yale University
John J. Ryan
John J. Ryan Virginia Commonwealth University
Kazuaki Takabe
Kazuaki Takabe Roswell Park Cancer Institute
Colin Eaborn
Colin Eaborn University of Sussex
David Neumark
David Neumark University of California, Irvine
David A. Gewirtz
David A. Gewirtz Virginia Commonwealth University
Rosanna Supino
Rosanna Supino University of Milan

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