World's Best Scientists 2026 revealed!

Overview

John J. Ryan is affiliated with Virginia Commonwealth University in the United States and has contributed extensively to the field of medical research, focusing primarily on areas within medicine such as cardiology, pulmonary and respiratory medicine, and immunology. Their work spans several subfields, including cardiovascular medicine and respiratory diseases.

The scientist has published more than 200 works, with significant activity in the following subfields:

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Immunology
  • Complementary and Alternative Medicine
  • Physiology

Research topics addressed by John J. Ryan include:

  • Pulmonary Hypertension Research and Treatments
  • Cardiovascular and Exercise Physiology
  • Cardiovascular Function and Risk Factors
  • Heart Failure Treatment and Management
  • Mast Cells and Histamine
  • Vascular Anomalies and Treatments
  • Asthma and Respiratory Diseases

Common venues for publishing their work include:

  • The Journal of Immunology
  • Pulmonary Circulation
  • Journal of Applied Physiology
  • American Journal of Respiratory and Critical Care Medicine
  • Cellular Immunology

Frequent collaborators with whom John J. Ryan has co-authored multiple papers are:

  • D. Walter Wray
  • Jeremy K. Alpenglow
  • Kanokwan Bunsawat
  • Teresa De Marco
  • Sydney Ann Kee

Among several recent publications, notable papers include:

  • The Impact of COVID-19 on Medical Education, 2020, Cureus
  • The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial, 2021, Nature Medicine
  • Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry, 2022, Journal of the American Heart Association
  • Lactate Is a Metabolic Mediator That Shapes Immune Cell Fate and Function, 2021, Frontiers in Physiology
  • Care of patients with pulmonary arterial hypertension during the coronavirus (COVID-19) pandemic, 2020, Pulmonary Circulation

Best Publications

  • The IL-4 receptor: signaling mechanisms and biologic functions.

    Keats Nelms;Achsah D. Keegan;José Zamorano;John J. Ryan

  • Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

    Glenn Marsboom;Peter T. Toth;John J. Ryan;Zhigang Hong

  • The Right Ventricle in Pulmonary Arterial Hypertension: Disorders of Metabolism, Angiogenesis and Adrenergic Signaling in Right Ventricular Failure

    John J. Ryan;Stephen L. Archer

  • Fullerene nanomaterials inhibit the allergic response

    John J. Ryan;Henry R. Bateman;Alex Stover;Greg Gomez

  • Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

    Willard W. Sharp;Yong Hu Fang;Mei Han;Hannah J. Zhang

  • Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase

    Sandra Odom;Gregorio Gomez;Martina Kovarova;Yasuko Furumoto

  • Cardiovascular Effects of Exposure to Cigarette Smoke and Electronic Cigarettes : Clinical Perspectives From the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology

    Pamela B. Morris;Brian A. Ference;Eiman Jahangir;Dmitriy N. Feldman

  • Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension.

    John J. Ryan;Stephen L. Archer

  • Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

    John J. Ryan;Lisa J. McReynolds;Achsah Keegan;Lu Hai Wang

  • Mast cell production and response to IL-4 and IL-13.

    Jamie J.A. McLeod;Bianca Baker;John J. Ryan

  • Stat5 expression is critical for mast cell development and survival.

    Christopher P Shelburne;Margaret E McCoy;Roland Piekorz;Veronika Sexl

  • Belumosudil for Chronic Graft-versus-Host Disease (cGVHD) After 2 or More Prior Lines of Therapy: The ROCKstar Study

    Corey S Cutler;Stephanie J Lee;Sally Arai;Marcello Rotta

  • FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate

    Lin Piao;Vaninder K. Sidhu;Yong Hu Fang;John J. Ryan

  • A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

    Megan M. Price;Carole A. Oskeritzian;Yves T. Falanga;Kuzhuvelil B. Harikumar

  • Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension.

    Lin Piao;Yong-Hu Fang;Kishan Parikh;John J. Ryan

  • Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.

    Amanda L Harris;Xiaohong Yang;Alex Hegmans;Lawrence Povirk

  • Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

    Scott A. Oakes;Scott A. Oakes;Fabio Candotti;James A. Johnston;Yi-Qing Chen

  • Mitochondrial dynamics in pulmonary arterial hypertension.

    John Ryan;Asish Dasgupta;Jessica Huston;Kuang-Huieh Chen

  • Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

    Carole A. Oskeritzian;Megan M. Price;Nitai C. Hait;Dmitri Kapitonov

  • IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo.

    Sarah Kennedy Norton;Brian Barnstein;Jennifer Brenzovich;Daniel P. Bailey

Frequent Co-Authors

Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University
Gary L. Bowlin
Gary L. Bowlin University of Memphis
Barbara D. Boyan
Barbara D. Boyan Virginia Commonwealth University
Caroline S. Fox
Caroline S. Fox MSD (United States)
Edward K. Wakeland
Edward K. Wakeland The University of Texas Southwestern Medical Center

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