DNA, Stereochemistry, Platinum, Adduct and Nucleotide excision repair are her primary areas of study. Her studies in DNA integrate themes in fields like Guanine and Cytotoxicity. The Cis–trans isomerism research Jana Kasparkova does as part of her general Stereochemistry study is frequently linked to other disciplines of science, such as Ligand, therefore creating a link between diverse domains of science.
Her Platinum research incorporates themes from Coordination complex and Pharmacology. The Adduct study which covers Oligonucleotide that intersects with Methylamine, Thiazole, Proton NMR, Thymine and Comet assay. Her research investigates the connection with Nucleotide excision repair and areas like Platinum Compound which intersect with concerns in DNA polymerase.
Jana Kasparkova mostly deals with DNA, Stereochemistry, Platinum, Biochemistry and Cytotoxicity. Her biological study spans a wide range of topics, including Bifunctional, Adduct and Guanine. Her Stereochemistry study incorporates themes from DNA polymerase, Molecule, Ligand and Ruthenium.
Her work carried out in the field of Platinum brings together such families of science as Combinatorial chemistry, Oxaliplatin and Pharmacology. Her work on Antitumor activity, HMG-box, Electrophoretic mobility shift assay and Gel electrophoresis as part of general Biochemistry study is frequently connected to DNA clamp, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. Her study in Cytotoxicity is interdisciplinary in nature, drawing from both Cancer cell, Cytotoxic T cell, Cell culture and Molecular biology.
Her primary areas of investigation include DNA, Medicinal chemistry, Cancer cell, Tris and Cancer research. Her DNA research is multidisciplinary, incorporating perspectives in Combinatorial chemistry, Enantiomer, Stereochemistry and Intercalation. Her Stereochemistry research includes themes of Radical, Cleavage and Mode of action.
Her Medicinal chemistry research incorporates elements of Denticity, Ligand, 1,2,3-Triazole and Dna interaction. Jana Kasparkova interconnects DNA damage, Mechanism of action, Moiety, Platinum and Prodrug in the investigation of issues within Cancer cell. Her work deals with themes such as Cinnamic acid and Spheroid, which intersect with Platinum.
The scientist’s investigation covers issues in Cancer cell, Combinatorial chemistry, DNA, Phenylbutyrate and DNA damage. The various areas that Jana Kasparkova examines in her Cancer cell study include Tumor microenvironment, Cancer stem cell, Cancer research and Propidium iodide. She has included themes like Cell culture, Mechanism of action, Oxaliplatin, Cytoskeleton and Cytotoxic T cell in her Cancer research study.
Her Combinatorial chemistry research integrates issues from Reactive oxygen species, Photodynamic therapy, Superoxide and Photosensitizer. In her research, Jana Kasparkova performs multidisciplinary study on DNA and Quinolone. Combining a variety of fields, including Phenylbutyrate, Moiety, Prodrug and Biological activity, are what the author presents in her essays.
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Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.
Viktor Brabec;Jana Kasparkova.
Drug Resistance Updates (2005)
A potent cytotoxic photoactivated platinum complex
Fiona S. Mackay;Julie A. Woods;Julie A. Woods;Pavla Heringová;Jana Kašpárková.
Proceedings of the National Academy of Sciences of the United States of America (2007)
DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent.
Viktor Brabec;Jana Kašpárková;Oldřich Vrána;Olga Nováková.
Double‐check probing of DNA bending and unwinding by XPA–RPA: an architectural function in DNA repair
Miriam Missura;Tonko Buterin;Robert Hindges;Ulrich Hübscher.
The EMBO Journal (2001)
Molecular aspects of resistance to antitumor platinum drugs.
Viktor Brabec;Jana Kasparkova.
Drug Resistance Updates (2002)
DNA Interstrand Cross-links of the Novel Antitumor Trinuclear Platinum Complex BBR3464 CONFORMATION, RECOGNITION BY HIGH MOBILITY GROUP DOMAIN PROTEINS, AND NUCLEOTIDE EXCISION REPAIR
Jana Kasparkova;Jana Zehnulova;Nicholas Farrell;Viktor Brabec.
Journal of Biological Chemistry (2002)
Conformation of DNA Modified by Monofunctional Ru(II) Arene Complexes: Recognition by DNA Binding Proteins and Repair. Relationship to Cytotoxicity
Olga Novakova;Jana Kasparkova;Vendula Bursova;Ctirad Hofr.
Chemistry & Biology (2005)
Mechanism of the formation of DNA–protein cross-links by antitumor cisplatin
Kateřina Chválová;Viktor Brabec;Jana Kašpárková.
Nucleic Acids Research (2007)
DNA interactions of bifunctional dinuclear platinum(II) antitumor agents
Renata Žaludová;Alena Žákovská;Jana Kašpárková;Zdenka Balcarová.
FEBS Journal (1997)
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.
Jana Kasparkova;Victoria Marini;Yousef Najajreh;Dan Gibson.
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