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Chemistry

D-Index
58
Citations
10162
World Ranking
10799
National Ranking
48

Overview

Jana Kasparkova is affiliated with the Czech Academy of Sciences in the Czech Republic. Their research spans across several interconnected fields, including chemistry, medicine, and materials science, with a particular focus on organic chemistry, materials chemistry, oncology, molecular biology, and inorganic chemistry.

The scientist's work covers a range of main topics, notably metal complexes synthesis and properties, click chemistry and applications, crystallization and solubility studies, X-ray diffraction in crystallography, synthesis and biological evaluation, ferrocene chemistry and applications, and nanoplatforms for cancer theranostics.

The following are some of the recent papers authored or co-authored by Jana Kasparkova:

  • Induction of immunogenic cell death in cancer cells by a photoactivated platinum(iv) prodrug, 2020, published in Inorganic Chemistry Frontiers
  • A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death, 2021, published in Inorganic Chemistry Frontiers
  • Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis, 2022, published in Journal of Medicinal Chemistry
  • A Multi-action PtIV Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells, 2020, published in Angewandte Chemie International Edition
  • Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis, 2023, published in Journal of Medicinal Chemistry

Jana Kasparkova frequently collaborates with a group of co-authors, including:

  • Viktor Brabec
  • Vojtěch Novohradský
  • Lenka Marková
  • Hana Kostrhunová
  • Jitka Prachařová

The scientist's research is regularly published in various venues, with a notable number of contributions to:

  • The Cambridge Structural Database
  • Journal of Medicinal Chemistry
  • Inorganic Chemistry Frontiers
  • Chemico-Biological Interactions
  • Angewandte Chemie International Edition

Best Publications

  • Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.

    Viktor Brabec;Jana Kasparkova

  • A potent cytotoxic photoactivated platinum complex

    Fiona S. Mackay;Julie A. Woods;Julie A. Woods;Pavla Heringová;Jana Kašpárková

  • Correlation between cytotoxicity and DNA binding of polypyridyl ruthenium complexes.

    O Nováková;J Kaspárková;O Vrána;P M van Vliet

  • DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent.

    Viktor Brabec;Jana Kašpárková;Oldřich Vrána;Olga Nováková

  • Double‐check probing of DNA bending and unwinding by XPA–RPA: an architectural function in DNA repair

    Miriam Missura;Tonko Buterin;Robert Hindges;Ulrich Hübscher

  • Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin

    Vojtech Novohradsky;Anna Rovira;Cormac Hally;Alex Galindo

  • Molecular aspects of resistance to antitumor platinum drugs.

    Viktor Brabec;Jana Kasparkova

  • DNA Interstrand Cross-links of the Novel Antitumor Trinuclear Platinum Complex BBR3464 CONFORMATION, RECOGNITION BY HIGH MOBILITY GROUP DOMAIN PROTEINS, AND NUCLEOTIDE EXCISION REPAIR

    Jana Kasparkova;Jana Zehnulova;Nicholas Farrell;Viktor Brabec

  • Mechanism of the formation of DNA–protein cross-links by antitumor cisplatin

    Kateřina Chválová;Viktor Brabec;Jana Kašpárková

  • Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

    Viktor Brabec;Jana Kasparkova

  • Cytotoxic platinum coordination compounds. DNA binding agents

    Viktor Brabec;Ondrej Hrabina;Ondrej Hrabina;Jana Kasparkova

  • Conformation of DNA Modified by Monofunctional Ru(II) Arene Complexes: Recognition by DNA Binding Proteins and Repair. Relationship to Cytotoxicity

    Olga Novakova;Jana Kasparkova;Vendula Bursova;Ctirad Hofr

  • DNA interactions of bifunctional dinuclear platinum(II) antitumor agents

    Renata Žaludová;Alena Žákovská;Jana Kašpárková;Zdenka Balcarová

  • Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes.

    Tijana Bugarcic;Olga Nováková;Anna Halámiková;Lenka Zerzánková

  • DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.

    Jana Kasparkova;Victoria Marini;Yousef Najajreh;Dan Gibson

  • DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes

    Olga Novakova;Jana Kasparkova;Jaroslav Malina;Giovanni Natile

  • The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes

    Tijana Bugarcic;Abraha Habtemariam;Jana Stepankova;Pavla Heringova

  • A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex

    Vojtech Novohradsky;Vojtech Novohradsky;Lenka Zerzankova;Jana Stepankova;Anna Kisova

  • Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.

    Jana Kasparkova;Marie Vojtiskova;Giovanni Natile;Viktor Brabec

  • Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes.

    Jana Kasparkova;Nicholas Farrell;Viktor Brabec

Frequent Co-Authors

Viktor Brabec
Viktor Brabec Czech Academy of Sciences
Nicholas Farrell
Nicholas Farrell Virginia Commonwealth University
Dan Gibson
Dan Gibson Hebrew University of Jerusalem
Peter J. Sadler
Peter J. Sadler University of Warwick
Giovanni Natile
Giovanni Natile University of Bari Aldo Moro
Abraha Habtemariam
Abraha Habtemariam University of Warwick
José Ruiz
José Ruiz University of Murcia
Simon Parsons
Simon Parsons University of Edinburgh
Kamil Kuca
Kamil Kuca University of Hradec Králové
Guy J. Clarkson
Guy J. Clarkson University of Warwick

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