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Chemistry

D-Index
48
Citations
14986
World Ranking
15044
National Ranking
112

Overview

Dan Gibson is affiliated with the Hebrew University of Jerusalem in Israel. Their research primarily focuses on the intersection of medicine and chemistry, with significant contributions to oncology and organic chemistry.

Their published work spans several key subfields including oncology, organic chemistry, biomaterials, molecular biology, and biomedical engineering. The scientist's investigations often revolve around metal complexes synthesis and properties, with additional research exploring ferrocene chemistry and applications, nanoparticle-based drug delivery, click chemistry, nanoplatforms for cancer theranostics, adenosine and purinergic signaling, and asymmetric hydrogenation and catalysis.

Some of the recent papers authored or co-authored by Dan Gibson include:

  • Platinum(IV) anticancer agents; are we en route to the holy grail or to a dead end? (2021), Journal of Inorganic Biochemistry
  • A Multi-action and Multi-target RuII-PtIV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers (2020), Angewandte Chemie International Edition
  • Multiaction Pt(IV) Carbamate Complexes Can Codeliver Pt(II) Drugs and Amine Containing Bioactive Molecules (2020), Inorganic Chemistry
  • Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs? (2021), Journal of Medicinal Chemistry
  • Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells (2020), Journal of Medicinal Chemistry

The scientist frequently collaborates with several researchers including Tomer Babu, Hana Kostrhunová, Viktor Brabec, Vojtěch Novohradský, and Subhendu Karmakar.

Dan Gibson's work has been published mostly in journals such as:

  • Journal of Medicinal Chemistry
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Dalton Transactions
  • Chemistry & Biodiversity

The main fields of study that Dan Gibson contributes to are medicine and chemistry, with a particular focus on therapeutic strategies in oncology. Their research addresses the synthesis and properties of metal complexes and explores applications in drug delivery systems and anticancer therapies. The topics bridge chemistry and biomedical research, reflecting interdisciplinary approaches to developing anticancer agents and exploring prodrug mechanisms.

Best Publications

  • ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR

    William A. Devane;Lumir Hanuš;Aviva Breuer;Roger G. Pertwee

  • X-ray structure of the major adduct of the anticancer drug cisplatin with DNA: cis-[Pt(NH3)2(d(pGpG))]

    Suzanne E. Sherman;Dan Gibson;Andrew H.-J. Wang;Stephen J. Lippard

  • What do we know about the reduction of Pt(IV) pro-drugs?

    Ezequiel Wexselblatt;Dan Gibson

  • Platinum(IV) anticancer prodrugs – hypotheses and facts

    Dan Gibson

  • Crystal and molecular structure of cis-[Pt(NH3)2{d(pGpG)}], the principal adduct formed by cis-diamminedichloroplatinum(II) with DNA

    Suzanne E. Sherman;Dan. Gibson;Andrew H. J. Wang;Stephen J. Lippard

  • Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies.

    Olga Aronov;Aviva T. Horowitz;and Alberto Gabizon;Dan Gibson

  • Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

    Jenny Z. Zhang;Ezequiel Wexselblatt;Trevor W. Hambley;Dan Gibson

  • The mechanism of action of platinum anticancer agents—what do we really know about it?

    Dan Gibson

  • A Multi-action and Multi-target Ru II -Pt IV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers.

    Johannes Karges;Thirumal Yempala;Mickaël Tharaud;Dan Gibson

  • Pt( iv ) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

    Raji Raveendran;Jeremy Phillip Braude;Ezequiel Wexselblatt;Vojtech Novohradsky

  • Is glutathione the major cellular target of cisplatin? A study of the interactions of cisplatin with cancer cell extracts.

    Yonit Kasherman;Stefan Sturup;Dan Gibson

  • Multi-action Pt(IV) anticancer agents; do we understand how they work?

    Dan Gibson

  • Interactions of cisplatin and transplatin with proteins. Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles.

    Tal Peleg-Shulman;Yousef Najajreh;Dan Gibson

  • Triple action Pt(IV) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

    Emanuele Petruzzella;Roman Sirota;Irene Solazzo;Valentina Gandin

  • Synthesis and antitumor activity of quinonoid derivatives of cannabinoids.

    Natalya M Kogan;Ruth Rabinowitz;Paloma Levi;Dan Gibson

  • A Quadruple-Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines.

    Emanuele Petruzzella;Jeremy Phillip Braude;Janice R. Aldrich-Wright;Valentina Gandin

  • DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.

    Jana Kasparkova;Victoria Marini;Yousef Najajreh;Dan Gibson

  • Facile Preparation of Mono‐, Di‐ and Mixed‐Carboxylato Platinum(IV) Complexes for Versatile Anticancer Prodrug Design

    Jenny Z. Zhang;Paul Bonnitcha;Ezequiel Wexselblatt;Alice V. Klein

  • Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines.

    Yousef Najajreh;Jose Manuel Perez;Carmen Navarro-Ranninger;Dan Gibson

  • Reduction of cis,trans,cis-[PtCl2(OCOCH3)2(NH3)2] by aqueous extracts of cancer cells.

    Alina Nemirovski;Yonit Kasherman;Yael Tzaraf;Dan Gibson

  • New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells.

    Vojtech Novohradsky;Lenka Zerzankova;Jana Stepankova;Oldrich Vrana

  • A mass spectral study of the binding of the anticancer drug cisplatin to ubiquitin

    Dan Gibson;Catherine E. Costello

Frequent Co-Authors

Viktor Brabec
Viktor Brabec Czech Academy of Sciences
Jana Kasparkova
Jana Kasparkova Czech Academy of Sciences
Rafik Karaman
Rafik Karaman Al-Quds University
Valentina Gandin
Valentina Gandin University of Padua
Michael Chorev
Michael Chorev Harvard University
Simon Benita
Simon Benita Hebrew University of Jerusalem
Yechezkel Barenholz
Yechezkel Barenholz Hebrew University of Jerusalem
Janice R. Aldrich-Wright
Janice R. Aldrich-Wright Western Sydney University
Andrew H.-J. Wang
Andrew H.-J. Wang Academia Sinica

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