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Chemistry

D-Index
94
Citations
36923
World Ranking
1681
National Ranking
12

Overview

Yechezkel Barenholz is affiliated with the Hebrew University of Jerusalem in Israel. Their research primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with a particular focus on molecular biology, biomaterials, biomedical engineering, surgery, and immunology.

The scientist's research topics include nanoparticle-based drug delivery, RNA interference and gene delivery, immunotherapy and immune responses, SARS-CoV-2 and COVID-19 research, oral microbiology and periodontitis research, immune response and inflammation, and bone metabolism and diseases.

Frequent coauthors in their work include Keren Turjeman, Ahuva Cern, Stella Chaushu, Yehuda Klein, and Yaelle Bavli.

Barenholz's publications have appeared in several prominent venues such as Pharmaceutics, ACS Nano, Journal of Controlled Release, UNC Libraries, and Frontiers in Veterinary Science.

Notable recent papers include:

  • Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines, 2022, Nature Nanotechnology
  • Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA-Lipid Complexes, 2023, ACS Nano
  • Immune Changes Induced by Orthodontic Forces: A Critical Review, 2021, Journal of Dental Research
  • Anti-PEG antibodies before and after a first dose of Comirnaty® (mRNA-LNP-based SARS-CoV-2 vaccine), 2023, Journal of Controlled Release
  • Immunorthodontics: in vivo gene expression of orthodontic tooth movement, 2020, Scientific Reports

The diversity of publication venues and topics illustrates a multidisciplinary approach, often addressing biomedical engineering challenges and molecular biology mechanisms related to drug delivery systems and immune response modulation.

Best Publications

  • Doxil®--the first FDA-approved nano-drug: lessons learned.

    Unknown

  • Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies.

    Alberto Gabizon;Hilary Shmeeda;Yechezkel Barenholz

  • Fluidity parameters of lipid regions determined by fluorescence polarization.

    Unknown

  • Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases

    Gilad Haran;Rivka Cohen;Liliana K Bar;Yechezkel Barenholz

  • A simple method for the preparation of homogeneous phospholipid vesicles.

    Barenholz Y;Gibbes D;Litman Bj;Goll J

  • Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing dicetylphosphate.

    Unknown

  • Fluorescence Depolarization Studies of Phase Transitions and Fluidity in Phospholipid Bilayers. 2. Two-Component Phosphatidylcholine Liposomes

    Barry R. Lentz;Barry R. Lentz;Y. Barenholz;T. E. Thompson

  • Liposome application: problems and prospects

    Unknown

  • Nomenclature for Synthetic Gene Delivery Systems

    P. L. Felgner;Y. Barenholz;J. P. Behr;S. H. Cheng

  • Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes

    Avi Schroeder;Joseph Kost;Yechezkel Barenholz

  • Nanomedicines: addressing the scientific and regulatory gap

    Sally Tinkle;Scott E McNeil;Stefan Mühlebach;Raj Bawa

  • Sphingomyelins in bilayers and biological membranes

    Y. Barenholz;Y. Barenholz;T.E. Thompson

  • A calorimetric and fluorescent probe study of the gel-liquid crystalline phase transition in small, single-lamellar dipalmitoylphosphatidylcholine vesicles.

    J. Suurkuusk;B. R. Lentz;Y. Barenholz;R. L. Biltonen

  • Gelation of liposome interior A novel method for drug encapsulation

    D.D. Lasic;P.M. Frederik;M.C.A. Stuart;Y. Barenholz

  • Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions

    Thomas J. Anchordoquy;Yechezkel Barenholz;Diana Boraschi;Michael Chorny

  • Liposome drugs' loading efficiency: a working model based on loading conditions and drug's physicochemical properties.

    Unknown

  • Ultrasound triggered release of cisplatin from liposomes in murine tumors.

    Avi Schroeder;Reuma Honen;Keren Turjeman;Alberto Gabizon

  • Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: pharmacokinetic studies in rodents and dogs.

    Alberto A. Gabizon;Yechezkel Barenholz;Meir Bialer

  • Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer.

    Unknown

  • DOTAP (and other cationic lipids): chemistry, biophysics, and transfection.

    Dmitri Simberg;Sarah Weisman;Yeshayahu Talmon;Yechezkel Barenholz

  • Hydration of Polyethylene Glycol-Grafted Liposomes

    Unknown

  • Ammonium Sulfate Gradients for Efficient and Stable Remote Loading of Amphipathic Weak Bases into Liposomes and Ligandoliposomes.

    Elijah M. Bolotin;Rivka Cohen;Liliana K. Bar;Noam Emanuel

  • Liposomes: Preparation, Characterization, and Preservation

    Unknown

  • Controlling liposomal drug release with low frequency ultrasound: mechanism and feasibility.

    Avi Schroeder;Yuval Avnir;Sarah Weisman;Yousef Najajreh

  • Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery☆

    D.D. Lasic;B. Čeh;M.C.A. Stuart;L. Guo

  • States of aggregation and phase transformations in mixtures of phosphatidylcholine and octyl glucoside.

    S. Almog;B. J. Litman;W. Wimley;J. Cohen

  • A calorimetric study of the thermotropic behavior of aqueous dispersions of natural and synthetic sphingomyelins.

    Y. Barenholz;J. Suurkuusk;D. Mountcastle;T. E. Thompson

  • Sphingolipid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions.

    Naava Naslavsky;Hilary Shmeeda;Gilgi Friedlander;Anat Yanai

  • Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome.

    János Szebeni;Péter Bedőcs;Zoltán Rozsnyay;Zsóka Weiszhár

  • Electrostatic and structural properties of complexes involving plasmid DNA and cationic lipids commonly used for gene delivery

    Nicolaas J Zuidam;Yechezkel Barenholz

  • Phase behavior, DNA ordering, and size instability of cationic lipoplexes. Relevance to optimal transfection activity.

    Dmitri Simberg;Dganit Danino;Yeshayahu Talmon;Abraham Minsky

  • Thermal behavior of synthetic sphingomyelin-cholesterol dispersions.

    T. N. Estep;D. B. Mountcastle;Y. Barenholz;R. L. Biltonen

  • Polysaccharide-oligoamine based conjugates for gene delivery.

    Tony Azzam;Hagit Eliyahu;Libi Shapira;Michal Linial

  • Relevancy of drug loading to liposomal formulation therapeutic efficacy.

    Yechezkel Barenholz

Frequent Co-Authors

Alberto Gabizon
Alberto Gabizon Shaare Zedek Medical Center
Shimon Gatt
Shimon Gatt Hebrew University of Jerusalem
Thomas E. Thompson
Thomas E. Thompson University of Virginia
Ranajit Pal
Ranajit Pal Advanced Bioscience Laboratories (United States)
Janos Szebeni
Janos Szebeni Semmelweis University
Abraham J. Domb
Abraham J. Domb Hebrew University of Jerusalem
Eliahu Zlotkin
Eliahu Zlotkin Hebrew University of Jerusalem
Yeshayahu Talmon
Yeshayahu Talmon Technion – Israel Institute of Technology
Gilad Haran
Gilad Haran Weizmann Institute of Science
Dganit Danino
Dganit Danino Technion – Israel Institute of Technology

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