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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
15241
World Ranking
10700
National Ranking
11

Overview

Janos Szebeni is affiliated with Semmelweis University in Hungary and has contributed extensively to research in the field of medicine. Their work spans several subfields including infectious diseases, immunology, immunology and allergy, pharmacology, and molecular biology.

The scientist has a substantial publication record, focusing particularly on topics such as SARS-CoV-2 and COVID-19 research, drug-induced adverse reactions, food allergy and anaphylaxis research, the complement system in diseases, heparin-induced thrombocytopenia and thrombosis, nanoparticle-based drug delivery, and RNA interference and gene delivery.

Notable recent papers include:

  • Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines, 2022, Nature Nanotechnology
  • Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA-Lipid Complexes, 2023, ACS Nano
  • Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals, 2020, Advanced Drug Delivery Reviews
  • Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement, 2021, Journal of Controlled Release
  • Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: Evidence for immunogenicity of PEG, 2023, Vaccine

Janos Szebeni frequently collaborates with a core group of researchers. Frequent co-authors include:

  • Tamás Mészáros
  • Gergely Tibor Kozma
  • Tamás Radovits
  • László Dézsi
  • Béla Merkely

The scientist has published multiple articles in several publication venues, with a concentration in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Preprints.org
  • Pharmaceutics
  • Journal of Controlled Release
  • ACS Nano

Best Publications

  • Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties.

    Seyed Moghimi;J. Szebeni

  • Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity.

    Janos Szebeni

  • Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®): possible role in hypersensitivity reactions

    Asher Chanan-Khan;J. Szebeni;S. Savay;L. Liebes

  • Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention.

    Janos Szebeni;Franco Muggia;Alberto Gabizon;Yechezkel Barenholz

  • Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

    Gergely Tibor Kozma;Taro Shimizu;Tatsuhiro Ishida;Janos Szebeni

  • Complement Activation by Cremophor EL as a Possible Contributor to Hypersensitivity to Paclitaxel: an In Vitro Study

    Janos Szebeni;Franco M. Muggia;Franco M. Muggia;Carl R. Alving

  • PEGylated liposomes: immunological responses

    Marwa Mohamed;Marwa Mohamed;Amr S. Abu Lila;Amr S. Abu Lila;Taro Shimizu;Eman Alaaeldin

  • Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biologicals.

    Janos Szebeni

  • Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management.

    David Rampton;Joergen Folkersen;Steven Fishbane;Michael Hedenus

  • Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process

    I. Hamad;A.C. Hunter;J. Szebeni;S.M. Moghimi

  • F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins.

    Milan Basta;Fredric Van Goor;Stefano Luccioli;Eric M. Billings

  • Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production

    S. Moein Moghimi;Islam Hamad;Thomas L. Andresen;Kent Jørgensen

  • Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20.

    Zsóka Weiszhár;Judit Czúcz;Csaba Révész;László Rosivall;László Rosivall

  • Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes: experimental and clinical studies.

    J. Szebeni;L. Baranyi;S. Savay;J. Milosevits

  • Hemodynamic Changes Induced by Liposomes and Liposome-Encapsulated Hemoglobin in Pigs A Model for Pseudoallergic Cardiopulmonary Reactions to Liposomes: Role of Complement and Inhibition by Soluble CR1 and Anti-C5a Antibody

    Janos Szebeni;John L. Fontana;Nabila M. Wassef;Paul D. Mongan

  • Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome.

    János Szebeni;Péter Bedőcs;Zoltán Rozsnyay;Zsóka Weiszhár

  • Animal Models of Complement-Mediated Hypersensitivity Reactions to Liposomes and Other Lipid-Based Nanoparticles

    János Szebeni;Carl R. Alving;László Rosivall;Rolf Bünger

  • Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction

    Janos Szebeni;Lajos Baranyi;Sandor Savay;Mihaly Bodo

  • Formation of complement-activating particles in aqueous solutions of Taxol: possible role in hypersensitivity reactions.

    Janos Szebeni;Carl R. Alving;Sandor Savay;Yechezkel Barenholz

  • Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents.

    Janos Szebeni

Frequent Co-Authors

Carl R. Alving
Carl R. Alving Walter Reed Army Institute of Research
Gert Storm
Gert Storm Utrecht University
Yechezkel Barenholz
Yechezkel Barenholz Hebrew University of Jerusalem
Mihály Józsi
Mihály Józsi Eötvös Loránd University
Franco M. Muggia
Franco M. Muggia New York University
Tom Eirik Mollnes
Tom Eirik Mollnes Oslo University Hospital
Thomas Lars Andresen
Thomas Lars Andresen Technical University of Denmark
Miklós Tóth
Miklós Tóth Cornell University
Nam-Joon Cho
Nam-Joon Cho Nanyang Technological University

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