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Biology and Biochemistry

D-Index
46
Citations
8495
World Ranking
18916
National Ranking
34

Overview

Mihály Józsi is affiliated with Eötvös Loránd University in Hungary and has a substantial body of research primarily in the fields of Medicine and Immunology and Microbiology. Their work focuses extensively on the study of the complement system in diseases, with significant contributions exploring related areas such as renal diseases, erythrocyte function, platelet disorders, and blood coagulation mechanisms.

The main research topics covered by Mihály Józsi include:

  • Complement system in diseases
  • Renal Diseases and Glomerulopathies
  • Erythrocyte Function and Pathophysiology
  • Platelet Disorders and Treatments
  • Blood Coagulation and Thrombosis Mechanisms
  • Phagocytosis and Immune Regulation
  • Blood groups and transfusion

Their recent scientific papers highlight detailed investigations into complement system components and their biological interactions. Notable recent publications include:

  • "Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice" (2021) in Frontiers in Immunology
  • "A Family Affair: Addressing the Challenges of Factor H and the Related Proteins" (2021) in Frontiers in Immunology
  • "Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization" (2020) in Frontiers in Immunology
  • "Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation" (2022) in Frontiers in Immunology
  • "Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm" (2021) in Frontiers in Immunology

Mihály Józsi has collaborated frequently with various coauthors. The most frequent collaborators are:

  • Barbara Uzonyi (19 joint publications)
  • Alexandra Papp (7 joint publications)
  • Dániel Bencze (7 joint publications)
  • Alexandra T. Matola (6 joint publications)
  • Zoltán Prohászka (5 joint publications)

The scholar's publications primarily appear in several scientific journals, most notably in Frontiers in Immunology, which accounts for thirteen of their works. Other venues include Immunobiology, Molecular Immunology, Kidney International, and BMC Ophthalmology.

In addition to journal articles, Mihály Józsi has contributed to book publications. One such work is "Updates on the Complement System in Kidney Diseases," published by Frontiers Media in 2023.

The subfields within immunology and medicine that frame their work include Immunology, Hematology, Nephrology, Physiology, and Molecular Biology. This diversity demonstrates the interdisciplinary approach to addressing complex biological and pathological mechanisms.

Best Publications

  • Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

    Timothy H.J. Goodship;H. Terence Cook;Fadi Fakhouri;Fernando C. Fervenza

  • Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency

    Mihály Józsi;Christoph Licht;Stefanie Strobel;Svante L. H. Zipfel

  • Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

    Tamara Manuelian;Jens Hellwage;Seppo Meri;Jessica Caprioli

  • Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

    Peter F Zipfel;Matthew Edey;Stefan Heinen;Mihály Józsi

  • C3 glomerulopathy — understanding a rare complement-driven renal disease

    Richard J.H. Smith;Gerald B. Appel;Anna M. Blom;H. Terence Cook

  • Factor H family proteins and human diseases.

    Mihály Józsi;Peter F. Zipfel;Peter F. Zipfel

  • Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)

    Maria Asuncion Abrera-Abeleda;Carla Nishimura;Jenna L.H. Smith;Sanjjev Sethi

  • Anti–factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome

    Mihály Józsi;Stefanie Strobel;Hans-Martin Dahse;Wei-shih Liu

  • Complement and diseases: defective alternative pathway control results in kidney and eye diseases.

    Peter F. Zipfel;Stefan Heinen;Mihály Józsi;Christine Skerka

  • Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

    C. Licht;S. Heinen;M. Józsi;I. Löschmann

  • The C‐terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein

    M. Oppermann;T. Manuelian;M. Józsi;E. Brandt

  • Factor H and Atypical Hemolytic Uremic Syndrome: Mutations in the C-Terminus Cause Structural Changes and Defective Recognition Functions

    Mihály Józsi;Stefan Heinen;Andrea Hartmann;Clemens W. Ostrowicz

  • Factor H-related proteins determine complement-activating surfaces.

    Mihály Józsi;Agustin Tortajada;Barbara Uzonyi;Elena Goicoechea de Jorge;Elena Goicoechea de Jorge

  • Leptospiral immunoglobulin-like proteins interact with human complement regulators Factor H, FHL-1, FHR-1, and C4BP

    Mónica Marcela Castiblanco-Valencia;Tatiana Rodrigues Fraga;Ludmila Bezerra da Silva;Denize Monaris

  • Factor h: a complement regulator in health and disease, and a mediator of cellular interactions.

    Anne Kopp;Mario Hebecker;Eliška Svobodová;Mihály Józsi

  • Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H

    M Mihlan;S Stippa;M Józsi;P F Zipfel;P F Zipfel

  • Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site.

    T. Sakari Jokiranta;Zhu Zhu Cheng;Harald Seeberger;Mihály Jòzsi

  • Anti-factor B autoantibody in dense deposit disease.

    Stefanie Strobel;Miriam Zimmering;Krisztián Papp;József Prechl

  • The C-terminus of complement factor H is essential for host cell protection.

    Mihály Józsi;Martin Oppermann;John D. Lambris;Peter F. Zipfel;Peter F. Zipfel

  • Factor H and Factor H-Related Protein 1 Bind to Human Neutrophils via Complement Receptor 3, Mediate Attachment to Candida albicans, and Enhance Neutrophil Antimicrobial Activity

    Josephine Losse;Peter F. Zipfel;Peter F. Zipfel;Mihály Józsi

Frequent Co-Authors

Peter F. Zipfel
Peter F. Zipfel Friedrich Schiller University Jena
Zoltán Prohászka
Zoltán Prohászka Semmelweis University
Christine Skerka
Christine Skerka Leibniz Association
T. Sakari Jokiranta
T. Sakari Jokiranta University of Helsinki
Santiago Rodríguez de Córdoba
Santiago Rodríguez de Córdoba Spanish National Research Council
Martin Oppermann
Martin Oppermann University of Göttingen
Margarita López-Trascasa
Margarita López-Trascasa Autonomous University of Madrid
Stephen J. Perkins
Stephen J. Perkins University College London
Seppo Meri
Seppo Meri University of Helsinki

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