World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
76
Citations
21511
World Ranking
1150
National Ranking
596

Research.com Recognitions

  • 1990 - Member of the National Academy of Sciences
  • 1989 - Nobel Prize for their discovery of catalytic properties of RNA
  • 1988 - Fellow of the American Academy of Arts and Sciences
  • 1987 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Sidney Altman is affiliated with Yale University in the United States. Their research outputs span multiple fields related to biochemistry, genetics, molecular biology, agricultural and biological sciences, and medicine. A substantial part of their work focuses on molecular biology, genetics, plant science, insect science, and public health, environmental and occupational health.

The primary topics in Altman's research include advanced biosensing and bioanalysis techniques, RNA interference and gene delivery, bacteriophages and microbial interactions, phytoplasmas and hemiptera pathogens, insect symbiosis and bacterial influences, mosquito-borne diseases and control, and microRNA in disease regulation.

They have collaborated frequently with several researchers, including Alexey A. Belogurov, Stanislav S. Terekhov, Alexander G. Gabibov, Olga Patutina, and Valentin V. Vlassov. These collaborations have contributed to their academic output, which is regularly published in a range of scientific journals.

Their recent papers include:

  • Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency, 2020, Proceedings of the National Academy of Sciences
  • Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells, 2021, Molecular Therapy - Nucleic Acids
  • Switchable targeting of solid tumors by BsCAR T cells, 2022, Proceedings of the National Academy of Sciences
  • A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding, 2020, Science Advances
  • Peptide conjugated morpholinos for management of the huanglongbing pathosystem, 2020, Pest Management Science

Frequent publication venues for Sidney Altman's work include:

  • Proceedings of the National Academy of Sciences
  • Molecular Therapy - Nucleic Acids
  • Science Advances
  • Pest Management Science
  • Viruses

Sidney Altman has received several awards for their contributions to science. These include the Nobel Prize in 1989 for the discovery of catalytic properties of RNA, membership in the National Academy of Sciences since 1990, fellowship of the American Academy of Arts and Sciences since 1988, and fellowship of the American Association for the Advancement of Science (AAAS) since 1987.

Best Publications

  • The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

    Cecilia Guerrier-Takada;Katheleen Gardiner;Terry Marsh;Norman Pace

  • RNA therapeutics: beyond RNA interference and antisense oligonucleotides

    Ryszard Kole;Adrian R. Krainer;Sidney Altman

  • External guide sequences for an RNA enzyme.

    Anthony C. Forster;Sidney Altman

  • Purification and Properties of a Specific Escherichia coli Ribonuclease which Cleaves a Tyrosine Transfer Ribonucleic Acid Precursor

    Hugh D. Robertson;Sidney Altman;John D. Smith

  • Ribonuclease P: an enzyme with an essential RNA component

    Benjamin C. Stark;Ryszard Kole;Emma J. Bowman;Sidney Altman

  • Model substrates for an RNA enzyme.

    William H. McClain;Cecilia Guerrier-Takada;Sidney Altman

  • Catalytic activity of an RNA molecule prepared by transcription in vitro

    Cecilia Guerrier-Takada;Sidney Altman

  • Tyrosine tRNA precursor molecule polynucleotide sequence.

    S. Altman;S. Altman;J. D. Smith

  • Targeted cleavage of mRNA by human RNase P

    Yan Yuan;Eun-Seong Hwang;Sidney Altman

  • Identification and characterization of an RNA molecule that copurifies with RNase P activity from HeLa cells.

    M Bartkiewicz;H Gold;S Altman

  • Characterization of an RNase P activity from HeLa cell mitochondria. Comparison with the cytosol RNase P activity.

    C J Doersen;C Guerrier-Takada;S Altman;G Attardi

  • Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity

    Stanislav S. Terekhov;Stanislav S. Terekhov;Ivan V. Smirnov;Ivan V. Smirnov;Anastasiya V. Stepanova;Tatyana V. Bobik;Tatyana V. Bobik

  • Protein-RNA interactions in the RNase P holoenzyme from Escherichia coli.

    Agustín Vioque;John Arnez;Sidney Altman

  • Role in translation of a triple tandemly repeated sequence in the 5′-untranslated region of human thymidylate synthase mRNA

    Sumiko Kaneda;Keiichi Takeishi;Dai Ayusawa;Kimiko Shimizu

  • Recent studies of ribonuclease P.

    Sidney Altman;Leif Kirsebom;Simon Talbot

  • Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli.

    Cecilia Guerrier-Takada;Karen Haydock;Leland Allen;Sidney Altman

  • Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P

    Madeline Baer;Timothy W. Nilsen;Christine Costigan;Sidney Altman

  • Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.

    Fenyong Liu;Sidney Altman

  • Similar cage-shaped structures for the RNA components of all ribonuclease P and ribonuclease MRP enzymes

    Anthony C. Forster;Sidney Altman

  • Kinetics of the processing of the precursor to 4.5 S RNA, a naturally occurring substrate for RNase P from Escherichia coli.

    Karen A. Peck-Miller;Sidney Altman

Frequent Co-Authors

Leif A. Kirsebom
Leif A. Kirsebom Uppsala University
Alfred L. M. Bothwell
Alfred L. M. Bothwell University of Arizona
Konstantin Severinov
Konstantin Severinov Rutgers, The State University of New Jersey
Choukri Ben Mamoun
Choukri Ben Mamoun Yale University
Hugh D. Robertson
Hugh D. Robertson Cornell University
Valentin V. Vlassov
Valentin V. Vlassov Russian Academy of Sciences
Eric Westhof
Eric Westhof University of Strasbourg
Jorge E. Galán
Jorge E. Galán Yale University
Themis R. Kyriakides
Themis R. Kyriakides Yale University
Joe Craft
Joe Craft Yale University

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