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Leif A. Kirsebom

Leif A. Kirsebom

D-Index & Metrics

Biology and Biochemistry

D-Index
42
Citations
5256
World Ranking
19514
National Ranking
313

Overview

Leif A. Kirsebom is affiliated with Uppsala University in Sweden, focusing on research within biochemistry, genetics, and molecular biology. Their work intersects primarily with molecular biology and genetics, with additional contributions in epidemiology, infectious diseases, and ecology.

Their research covers a range of topics, prominently including:

  • RNA and protein synthesis mechanisms
  • Bacterial genetics and biotechnology
  • RNA modifications and cancer
  • Mycobacterium research and diagnosis
  • Tuberculosis research and epidemiology
  • Genomics and phylogenetic studies
  • Bacteriophages and microbial interactions

Among their recent publications are the following papers:

  • "The discovery of a catalytic RNA within RNase P and its legacy" (2024), Journal of Biological Chemistry
  • "Comparative genome analysis of mycobacteria focusing on tRNA and non-coding RNA" (2022), BMC Genomics
  • "Tribute to Sidney AltmanSIDNEY ALTMAN: AN EXEMPLARY SCIENTIST, TEACHER, AND FRIEND (1939-2022)SIDNEY ALTMAN'S GREATEST ACHIEVEMENTA SHORT HISTORY OF THE DISCOVERY OF THE ESSENTIAL RNA COMPONENT OF RNase PRECOLLECTIONS OF A GRADUATE STUDENT IN SIDNEY ALTMAN'S LABORATORYMEMORIES FROM THE EARLY YEARS OF THE SIDNEY ALTMAN LABORATORYTHE SPINACH CHLOROPLAST RNase P: THE FIRST PROTEIN-ONLY RNase P!SIDNEY ALTMAN: A BRIEF MEMOIRSIDNEY ALTMAN: IN MEMORIAM ET GRATITUDINEMTALES OF THE UNEXPECTED IN SIDNEY ALTMAN'S LABORATORYTO CLEAVE OR NOT TO CLEAVE, THAT IS THE QUESTIONSIDNEY ALTMAN: CHALLENGING AUTHORITY AND BEING AN ERUDITE SCHOLARTRIBUTE TO MY BELOVED MENTOR, SIDNEY ALTMANHAVING A MENTOR FOR AN ERAIN MEMORY OF PROFESSOR SIDNEY ALTMAN: INSPIRING PEOPLE TO THE FULLHALF A CENTURY WITH SIDNEY ALTMANRECOLLECTIONS OF MY FRIENDSHIP WITH SID ALTMANPERSONAL MEMORIES OF SIDNEY ALTMANA REMARKABLE CATALYSTREMEMBERING SIDNEY ALTMANSIDNEY ALTMAN-A SCIENTIFIC ODYSSEYSID ALTMAN: FRIEND, COLLEAGUE, AND GODFATHERSIDNEY ALTMAN-A REMEMBRANCERECOLLECTIONS OF MY SCIENTIFIC INTERACTIONS WITH SIDNEY ALTMANSIDNEY ALTMAN'S TIES TO CHINATARGETING RNA TO FIGHT ANTIBIOTIC-RESISTANT BACTERIASIDNEY ALTMAN: IN HIS OWN WORDS" (2022), RNA
  • "Intracellular localization of the mycobacterial stressosome complex" (2021), Scientific Reports
  • "Importance of residue 248 in Escherichia coli RNase P RNA mediated cleavage" (2023), Scientific Reports

Scientific Reports, Journal of Biological Chemistry, RNA, BMC Genomics, and bioRxiv (Cold Spring Harbor Laboratory) are among the frequent publication venues associated with this scientist.

Their collaborations include frequent co-authors such as Phani Rama Krishna Behra, Malavika Ramesh, Santanu Dasgupta, Venkat Gopalan, and B. M. Fredrik Pettersson.

Best Publications

  • Base pairing between Escherichia coli RNase P RNA and its substrate.

    Leif A Kirsebom;Staffan G Svärd

  • Eukaryotic RNase P RNA mediates cleavage in the absence of protein

    Ema Kikovska;Staffan G. Svärd;Leif A. Kirsebom

  • Recent studies of ribonuclease P.

    Sidney Altman;Leif Kirsebom;Simon Talbot

  • Sporulation in mycobacteria

    Jaydip Ghosh;Pontus Larsson;Bhupender Singh;B. M. Fredrik Pettersson

  • Inhibition of RNase P RNA cleavage by aminoglycosides.

    Nils E. Mikkelsen;Mathias Brännvall;Anders Virtanen;Leif A. Kirsebom

  • Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects.

    Lien B. Lai;Agustín Vioque;Leif A. Kirsebom;Venkat Gopalan

  • RNase P RNA mediated cleavage: substrate recognition and catalysis.

    Leif A. Kirsebom

  • Aminoglycoside binding displaces a divalent metal ion in a tRNA–neomycin B complex

    Nils E. Mikkelsen;Kenth Johansson;Anders Virtanen;Leif A. Kirsebom

  • Synthesis of RNA using 2'-O-DTM protection.

    Andrey Semenyuk;Andras Földesi;Tommy Johansson;Camilla Estmer-Nilsson

  • Product release is a rate-limiting step during cleavage by the catalytic RNA subunit of Escherichia Coli RNase P

    Annika Tallsjö;Leif A. Kirsebom

  • The kinetics and specificity of cleavage by RNase P is mainly dependent on the structure of the amino acid acceptor stem.

    Leif A. Kirsebom;Staffan G. Svärd

  • Differential role of the intermolecular base-pairs G292-C(75) and G293-C(74) in the reaction catalyzed by Escherichia coli RNase P RNA.

    Silke Busch;Leif A Kirsebom;Holger Notbohm;Roland K Hartmann

  • Differential effects of mutations in the protein and RNA moieties of RNase P on the efficiency of suppression by various tRNA suppressors.

    Leif A. Kirsebom;Madeline F. Baer;Sidney Altman

  • Differentiation of Chlamydia spp. by sequence determination and restriction endonuclease cleavage of RNase P RNA genes.

    Björn Herrmann;Ola Winqvist;Jens G Mattsson;Leif A Kirsebom

  • Involvement of ribosomal protein L7/L12 in control of translational accuracy

    Leif A Kirsebom;Leif A Isaksson

  • Phylogenetic comparative mutational analysis of the base-pairing between RNase P RNA and its substrate.

    Staffan G Svärd;Ulrika Kagardt;Leif A Kirsebom

  • Catalysis by the RNA subunit of RNase P — a minireview ☆

    S Altman;MF Baer;M Bartkiewicz;H Gold

  • Metal ion cooperativity in ribozyme cleavage of RNA

    Mathias Brännvall;Leif A. Kirsebom

  • The NMR Structure of 31mer RNA Domain of Escherichia Coli RNase P RNA Using Its Non-Uniformly Deuterium Labelled Counterpart [the ‘NMR-window’ Concept]

    C Glemarec;J Kufel;A Földesi;T Maltseva

  • Correction for Eukaryotic RNase P RNA mediates cleavage in the absence of protein

    Ema Kikovska;Staffan G. Svärd;Leif A. Kirsebom

Frequent Co-Authors

Staffan G. Svärd
Staffan G. Svärd Uppsala University
Sidney Altman
Sidney Altman Yale University
Roland K. Hartmann
Roland K. Hartmann Philipp University of Marburg
Ola Winqvist
Ola Winqvist Karolinska University Hospital
E. Gerhart H. Wagner
E. Gerhart H. Wagner Uppsala University
Måns Ehrenberg
Måns Ehrenberg Uppsala University
Charles G. Kurland
Charles G. Kurland Lund University
Per Olcén
Per Olcén Örebro University
Jonas Blomberg
Jonas Blomberg Uppsala University
Roderich D. Süssmuth
Roderich D. Süssmuth Technical University of Berlin

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