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Chemistry

D-Index
81
Citations
19711
World Ranking
3321
National Ranking
1095

Biology and Biochemistry

D-Index
81
Citations
19874
World Ranking
3949
National Ranking
1949

Research.com Recognitions

  • 2018 - Monie A. Ferst Award, Sigma Xi
  • 2014 - Fellow of the American Chemical Society
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Carol A. Fierke is a researcher affiliated with Texas A&M University in the United States. Their work spans multiple disciplines within biochemistry, genetics, and molecular biology, with a significant focus on molecular biology subfields.

Their research covers a variety of topics, including:

  • Histone Deacetylase Inhibitors Research
  • SARS-CoV-2 and COVID-19 Research
  • Computational Drug Discovery Methods
  • RNA and Protein Synthesis Mechanisms
  • RNA Modifications and Cancer
  • Protein Degradation and Inhibitors
  • Peptidase Inhibition and Analysis

Carol A. Fierke's publication record includes papers in diverse venues, reflecting broad interests in biochemistry and molecular biology. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biopolymers
  • The FASEB Journal
  • ChemMedChem
  • Proceedings of the National Academy of Sciences

Notable recent papers authored or co-authored by Carol A. Fierke include:

  • A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors, 2020, ChemMedChem
  • Unexpected specificity within dynamic transcriptional protein-protein complexes, 2020, Proceedings of the National Academy of Sciences
  • Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA, 2020, Nucleic Acids Research
  • Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors, 2024, ACS Central Science
  • Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P, 2020, RNA

The scientist frequently collaborates with several co-authors, with multiple joint publications with:

  • Shiqing Xu
  • Wenshe Ray Liu
  • Yan Sheng
  • Kai S. Yang
  • Elkan Blout

Carol A. Fierke's research contributions have been recognized through several awards, including:

  • Monie A. Ferst Award, Sigma Xi (2018)
  • Fellow of the American Chemical Society (2014)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2006)

Best Publications

  • Function and mechanism of zinc metalloenzymes.

    Keith A. McCall;Chih Chin Huang;Carol A. Fierke

  • Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

    Carol A. Fierke;Kenneth A. Johnson;Stephen J. Benkovic

  • Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design

    David W. Christianson;Carol A. Fierke

  • Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli.

    Teru Ogura;Koichi Inoue;Takashi Tatsuta;Toshinobu Suzaki

  • Measuring Picomolar Intracellular Exchangeable Zinc in PC-12 Cells Using a Ratiometric Fluorescence Biosensor

    Rebecca A. Bozym;Richard B. Thompson;Andrea K. Stoddard;Carol A. Fierke

  • Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion

    C. J. Frederickson;L. J. Giblin;A. Krezel;D. J. McAdoo

  • Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II.

    Ronald A. Venters;Ronald A. Venters;Bennett T. Farmer;Bennett T. Farmer;Carol A. Fierke;Carol A. Fierke;Leonard D. Spicer;Leonard D. Spicer

  • Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.

    Jane E. Jackman;Carol A. Fierke;L.Nathan Tumey;Michael Pirrung

  • Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA

    S. Niranjanakumari;Travis Stams;Sharon M. Crary;David W. Christianson

  • Protein Component of Bacillus subtilis RNase P Specifically Enhances the Affinity for Precursor-tRNAAsp †

    Jeffrey C. Kurz;S. Niranjanakumari;Carol A. Fierke

  • Structural Studies of Human Histone Deacetylase 8 and its Site-Specific Variants Complexed with Substrate and Inhibitors

    Daniel P. Dowling;Stephanie L. Gantt;Samuel G. Gattis;Carol A. Fierke

  • Zinc hydrolases: the mechanisms of zinc-dependent deacetylases.

    Marcy Hernick;Carol A. Fierke

  • Biochemical characterization of the Yersinia YopT protease: Cleavage site and recognition elements in Rho GTPases

    Feng Shao;Panayiotis O. Vacratsis;Zhaoqin Bao;Katherine E. Bowers

  • Hydrogen bond network in the metal binding site of carbonic anhydrase enhances zinc affinity and catalytic efficiency

    Laura L. Kiefer;Steven A. Paterno;Carol A. Fierke

  • Ribonuclease P Protein Structure: Evolutionary Origins in the Translational Apparatus

    Travis Stams;S. Niranjanakumari;S. Niranjanakumari;Carol A. Fierke;Carol A. Fierke;David W. Christianson;David W. Christianson

  • Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.

    Douglas A. Whittington;Kristin M. Rusche;Hyunshun Shin;Carol A. Fierke

  • Insights into enzyme function from studies on mutants of dihydrofolate reductase

    S. J. Benkovic;C. A. Fierke;A. M. Naylor

  • Catalytic Activity and Inhibition of Human Histone Deacetylase 8 Is Dependent on the Identity of the Active Site Metal Ion

    Stephanie L. Gantt;Samuel G. Gattis;Carol A. Fierke

  • Evidence for a Catalytic Role of Zinc in Protein Farnesyltransferase SPECTROSCOPY OF Co2+-FARNESYLTRANSFERASE INDICATES METAL COORDINATION OF THE SUBSTRATE THIOLATE

    Chih-Chin Huang;Patrick J. Casey;Carol A. Fierke

  • Catalysis and Inhibition of Human Carbonic Anhydrase IV

    Teaster T. Baird;Abdul Waheed;Torayuki Okuyama;William S. Sly

Frequent Co-Authors

David W. Christianson
David W. Christianson University of Pennsylvania
Xin Liu
Xin Liu Chinese Academy of Sciences
Ayyalusamy Ramamoorthy
Ayyalusamy Ramamoorthy Florida State University
Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Eric J. Toone
Eric J. Toone Duke University
Richard A. Gibbs
Richard A. Gibbs Baylor College of Medicine
David R. Engelke
David R. Engelke University of Michigan–Ann Arbor
James E. Penner-Hahn
James E. Penner-Hahn University of Michigan–Ann Arbor
Patrick J. Casey
Patrick J. Casey National University of Singapore
Christian R. H. Raetz
Christian R. H. Raetz Duke University

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