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Chemistry

D-Index
120
Citations
57165
World Ranking
494
National Ranking
214

Biology and Biochemistry

D-Index
122
Citations
59355
World Ranking
579
National Ranking
369

Research.com Recognitions

  • 2015 - Fellow, National Academy of Inventors
  • 2009 - US President's National Medal of Science "For his research contributions in the field of bioorganic chemistry, which have changed our understanding of how enzymes function and advanced the identification of targets and strategies for drug design. ", Presented by President Barack H. Obama in the East Room of the White House on November 17, 2010.
  • 1987 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1985 - Member of the National Academy of Sciences
  • 1984 - Fellow of the American Academy of Arts and Sciences
  • 1975 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1968 - Fellow of Alfred P. Sloan Foundation

Overview

Stephen J. Benkovic is affiliated with Pennsylvania State University in the United States. Their research activities predominantly span the field of Biochemistry, Genetics, and Molecular Biology, making significant contributions to molecular biology among various subfields including physiology, genetics, computational mechanics, and cell biology.

Their scholarly output addresses a range of topics, notably biochemical and molecular research, RNA modifications and cancer, DNA repair mechanisms, adenosine and purinergic signaling, ion-surface interactions and analysis, bacteriophages and microbial interactions, as well as bacterial genetics and biotechnology.

Recent publications by Stephen J. Benkovic include:

  • "Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells," 2020, Science
  • "Human de novo purine biosynthesis," 2020, Critical Reviews in Biochemistry and Molecular Biology
  • "Metabolic channeling: predictions, deductions, and evidence," 2021, Molecular Cell
  • "The Purinosome: A Case Study for a Mammalian Metabolon," 2022, Annual Review of Biochemistry
  • "Hypoxia drives the assembly of the multienzyme purinosome complex," 2020, Journal of Biological Chemistry

They have coauthored frequently with a number of researchers, including Vidhi Pareek, Anthony M. Pedley, Jingxuan He, Nicholas Winograd, and Ling-Nan Zou.

Stephen J. Benkovic's publications appear predominantly in several key journals, such as the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), Annual Review of Biochemistry, Nature Communications, and Science.

The scientist's career has been recognized through a variety of awards and honors. These include Fellowship of the National Academy of Inventors in 2015, the US President's National Medal of Science in 2009 presented by President Barack H. Obama, Fellowship of the American Association for the Advancement of Science in 1987, Membership in the National Academy of Sciences in 1985, Fellowship of the American Academy of Arts and Sciences in 1984, Fellowship of the John Simon Guggenheim Memorial Foundation in 1975, and Fellowship of the Alfred P. Sloan Foundation in 1968.

Best Publications

  • Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda

    William D. Huse;Lakshmi Sastry;Sheila A. Iverson;Angray S. Kang;Angray S. Kang

  • Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

    Carlos F. Barbas;Angray S. Kang;Richard A. Lerner;Stephen J. Benkovic

  • A Perspective on Enzyme Catalysis

    Stephen J. Benkovic;Sharon Hammes-Schiffer

  • Colloidal Au-Enhanced Surface Plasmon Resonance for Ultrasensitive Detection of DNA Hybridization

    Lin He;Michael D. Musick;Sheila R. Nicewarner;Frank G. Salinas

  • On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

    Xiaoyun Ding;Sz-Chin Steven Lin;Brian Kiraly;Hongjun Yue

  • At the crossroads of chemistry and immunology: Catalytic antibodies

    Richard A. Lerner;Stephen J. Benkovic;Peter G. Schultz

  • Allosteric regulation and catalysis emerge via a common route.

    Nina M Goodey;Stephen J Benkovic

  • Relating Protein Motion to Catalysis

    Sharon Hammes-Schiffer;Stephen J. Benkovic

  • Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

    Angray S. Kang;Carlos F. Barbas;Kim D. Janda;Stephen J. Benkovic

  • An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.

    Fernando L. Rock;Weimin Mao;Anya Yaremchuk;Mikhail Tukalo

  • Reversible compartmentalization of de novo purine biosynthetic complexes in living cells.

    Songon An;Ravindra Kumar;Erin D. Sheets;Stephen J. Benkovic

  • Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

    Carol A. Fierke;Kenneth A. Johnson;Stephen J. Benkovic

  • A New View into the Regulation of Purine Metabolism: The Purinosome

    Anthony M. Pedley;Stephen J. Benkovic

  • Network of coupled promoting motions in enzyme catalysis

    Pratul K. Agarwal;Salomon R. Billeter;P. T. Ravi Rajagopalan;Stephen J. Benkovic

  • A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

    Gira Bhabha;Jeeyeon Lee;Damian C. Ekiert;Jongsik Gam

  • Production of cyclic peptides and proteins in vivo.

    Charles P. Scott;Ernesto Abel-Santos;Mark Wall;Daphne C. Wahnon

  • Kinetic Mechanism of DNA Polymerase I (Klenow)

    R. D. Kuchta;V. Mizrahi;P. A. Benkovic;K. A. Johnson

  • Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.

    James A. Peliska;Stephen J. Benkovic

  • Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids

    Ralph Hirschmann;Amos B. Smith;Carol M. Taylor;Patricia A. Benkovic

  • A combinatorial approach to hybrid enzymes independent of DNA homology.

    Marc Ostermeier;Jae Hoon Shim;Stephen J. Benkovic

Frequent Co-Authors

Richard A. Lerner
Richard A. Lerner Scripps Research Institute
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Dale L. Boger
Dale L. Boger Scripps Research Institute
Jon D. Stewart
Jon D. Stewart University of Florida
Kim D. Janda
Kim D. Janda Scripps Research Institute
Sharon Hammes-Schiffer
Sharon Hammes-Schiffer Yale University
Vincent Croquette
Vincent Croquette École Normale Supérieure
Peter E. Wright
Peter E. Wright Scripps Research Institute
Gordon G. Hammes
Gordon G. Hammes Duke University

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