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Molecular Biology

D-Index
107
Citations
32946
World Ranking
421
National Ranking
241

Research.com Recognitions

  • 2006 - Member of the National Academy of Sciences
  • 1996 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Mike O'Donnell is affiliated with Rockefeller University in the United States and works primarily in the field of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology. Their research extends into related subfields including Genetics, Plant Science, Ecology, and Oncology.

The scientist has contributed extensively to topics such as:

  • DNA Repair Mechanisms
  • DNA and Nucleic Acid Chemistry
  • Genomics and Chromatin Dynamics
  • Bacterial Genetics and Biotechnology
  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • RNA Interference and Gene Delivery

Recent papers authored include:

  • Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome (2020, Nature Communications)
  • DNA unwinding mechanism of a eukaryotic replicative CMG helicase (2020, Nature Communications)
  • Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA (2020, Proceedings of the National Academy of Sciences)
  • Replisome bypass of a protein-based R-loop block by Pif1 (2020, Proceedings of the National Academy of Sciences)
  • DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp (2022, Nature Structural & Molecular Biology)

Frequent co-authors of Mike O'Donnell include:

  • Huilin Li
  • Roxana E. Georgescu
  • Nina Y. Yao
  • Fengwei Zheng
  • Olga Yurieva

The primary venues for publications are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Nature Structural & Molecular Biology
  • eLife

Mike O'Donnell has been recognized with awards including the Member of the National Academy of Sciences in 2006 and Fellow of the Indian National Academy of Engineering (INAE) since 1996.

Best Publications

  • Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA

    Jacqueline M Gulbis;Zvi Kelman;Jerard Hurwitz;Mike O'Donnell;Mike O'Donnell

  • Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

    Xiang-Peng Kong;Rene Onrust;Mike O'Donnell;John Kuriyan;John Kuriyan

  • Cellular DNA replicases: components and dynamics at the replication fork.

    Aaron Johnson;Mike O'Donnell

  • UmuD′2C is an error-prone DNA polymerase, Escherichia coli pol V

    Mengjia Tang;Xuan Shen;Ekaterina G. Frank;Mike O’Donnell

  • Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme

    H. Flores-Rozas;Z. Kelman;F. B. Dean;Zhen-Qiang Pan

  • Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

    Mengjia Tang;Phuong Pham;Xuan Shen;John-Stephen Taylor

  • Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex

    Gregory D. Bowman;Mike O'Donnell;John Kuriyan;John Kuriyan

  • Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme.

    P.T. Stukenberg;P.S. Studwell-Vaughan;M. O'Donnell

  • Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

    Ari J. Firestone;Joshua S. Weinger;Maria Maldonado;Kari Barlan

  • Human Cd4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen Ebna1

    Christian Münz;Kara L. Bickham;Marion Subklewe;Ming L. Tsang

  • Crystal Structure of the Processivity Clamp Loader Gamma (γ) Complex of E. coli DNA Polymerase III

    David Jeruzalmi;Mike O'Donnell;John Kuriyan

  • Principles and concepts of DNA replication in bacteria, archaea, and eukarya

    Michael O’Donnell;Lance Langston;Bruce Stillman

  • Sliding Clamps of DNA Polymerases

    John Kuriyan;Mike O'Donnell

  • An interaction between DNA ligase I and proliferating cell nuclear antigen: Implications for Okazaki fragment synthesis and joining

    David S. Levin;Wei Bai;Nina Yao;Michael O’Donnell

  • Saccharomyces cerevisiae MutLα Is a Mismatch Repair Endonuclease

    Farid A. Kadyrov;Shannon F. Holmes;Mercedes E. Arana;Olga A. Lukianova

  • Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III.

    Brian Guenther;Rene Onrust;Andrej Sali;Mike O'Donnell;Mike O'Donnell;Mike O'Donnell

  • Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III.

    David Jeruzalmi;Olga Yurieva;Yanxiang Zhao;Matthew Young

  • Trading places on DNA--a three-point switch underlies primer handoff from primase to the replicative DNA polymerase.

    Alexander Yuzhakov;Zvi Kelman;Mike O’Donnell;Mike O’Donnell

  • Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases.

    Nina Yao;Jennifer Turner;Zvi Kelman;P. Todd Stukenberg

  • Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme.

    Alexander Yuzhakov;Zvi Kelman;Jerard Hurwitz;Mike O'Donnell;Mike O'Donnell

Frequent Co-Authors

John Kuriyan
John Kuriyan Vanderbilt University
Myron F. Goodman
Myron F. Goodman University of Southern California
Huilin Li
Huilin Li Van Andel Institute
Jerard Hurwitz
Jerard Hurwitz Memorial Sloan Kettering Cancer Center
Antoine M. van Oijen
Antoine M. van Oijen Illawarra Health and Medical Research Institute
Roger Woodgate
Roger Woodgate National Institutes of Health
Frank Uhlmann
Frank Uhlmann The Francis Crick Institute
Paul Modrich
Paul Modrich Duke University
Nicholas E. Dixon
Nicholas E. Dixon University of Wollongong
Lori Frappier
Lori Frappier University of Toronto

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