World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
70
Citations
19469
World Ranking
1413
National Ranking
109

Research.com Recognitions

  • 2015 - Fellow of the Royal Society, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Frank Uhlmann is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology as the core subfield of study.

The scientist's work covers several topics, including:

  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • RNA and Protein Synthesis Mechanisms
  • DNA Repair Mechanisms
  • Fungal and Yeast Genetics Research
  • Chromosomal and Genetic Variations
  • DNA and Nucleic Acid Chemistry

Frank Uhlmann has published numerous papers across various journals, with some notable recent publications being:

  • A Structure-Based Mechanism for DNA Entry into the Cohesin Ring, 2020, Molecular Cell
  • Bridging-induced phase separation induced by cohesin SMC protein complexes, 2021, Science Advances
  • A Brownian ratchet model for DNA loop extrusion by the cohesin complex, 2021, eLife
  • Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment, 2020, Molecular Cell
  • SMC complexes: Lifting the lid on loop extrusion, 2022, Current Opinion in Cell Biology

Frequent coauthors who have contributed to their work include:

  • Maxim I. Molodtsov
  • Céline Bouchoux
  • Christopher Barrington
  • Masashi Minamino
  • Georgii Pobegalov

Regarding publication venues, Frank Uhlmann has published extensively in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Science Advances
  • Cell
  • The EMBO Journal

The scientist has received recognition including election as a Fellow of the Royal Society, United Kingdom in 2015 and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

    Frank Uhlmann;Friedrich Lottspeich;Kim Nasmyth

  • Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast

    Frank Uhlmann;Dominik Wernic;Marc André Poupart;Eugene V. Koonin

  • Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.

    Attila Tóth;Rafal Ciosk;Frank Uhlmann;Marta Galova

  • Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion

    Tom Rolef Ben-Shahar;Sebastian Heeger;Chris Lehane;Philip East

  • Cohesin relocation from sites of chromosomal loading to places of convergent transcription

    Armelle Lengronne;Yuki Katou;Saori Mori;Saori Mori;Shihori Yokobayashi

  • Cohesion between sister chromatids must be established during DNA replication

    Frank Uhlmann;Kim Nasmyth

  • SMC complexes: from DNA to chromosomes

    Frank Uhlmann

  • Disjunction of Homologous Chromosomes in Meiosis I Depends on Proteolytic Cleavage of the Meiotic Cohesin Rec8 by Separin

    Sara B.C Buonomo;Rosemary K Clyne;Joerg Fuchs;Josef Loidl

  • Splitting the chromosome: cutting the ties that bind sister chromatids.

    Nasmyth K;Peters Jm;Uhlmann F

  • Phosphorylation of the Cohesin Subunit Scc1 by Polo/Cdc5 Kinase Regulates Sister Chromatid Separation in Yeast

    Gabriela Alexandru;Frank Uhlmann;Karl Mechtler;Marc-André Poupart

  • Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability

    Hai Rao;Frank Uhlmann;Kim Nasmyth;Alexander Varshavsky

  • Biochemical reconstitution of topological DNA binding by the cohesin ring

    Yasuto Murayama;Frank Uhlmann

  • Identification of cis-acting sites for condensin loading onto budding yeast chromosomes

    Claudio D’Ambrosio;Christine Katrin Schmidt;Yuki Katou;Gavin Kelly

  • Cdc14 Phosphatase Induces rDNA Condensation and Resolves Cohesin-Independent Cohesion during Budding Yeast Anaphase

    Matt Sullivan;Toru Higuchi;Vittorio L Katis;Frank Uhlmann

  • Establishment of Sister Chromatid Cohesion at the S. cerevisiae Replication Fork

    Armelle Lengronne;Armelle Lengronne;John McIntyre;Yuki Katou;Yutaka Kanoh

  • Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase

    Takeshi Tomonaga;Koji Nagao;Yosuke Kawasaki;Kanji Furuya

  • Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast

    Ethel Queralt;Chris Lehane;Bela Novak;Bela Novak;Frank Uhlmann

  • DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism

    Yasuto Murayama;Frank Uhlmann

  • A model for ATP hydrolysis-dependent binding of cohesin to DNA.

    Stefan Weitzer;Chris Lehane;Frank Uhlmann

  • Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation

    Toru Higuchi;Frank Uhlmann

Frequent Co-Authors

Kim Nasmyth
Kim Nasmyth University of Oxford
Bela Novak
Bela Novak University of Oxford
Ambrosius P. Snijders
Ambrosius P. Snijders The Francis Crick Institute
Jan-Michael Peters
Jan-Michael Peters Research Institute of Molecular Pathology
Paul A. Bates
Paul A. Bates The Francis Crick Institute
Jerard Hurwitz
Jerard Hurwitz Memorial Sloan Kettering Cancer Center
Mike O'Donnell
Mike O'Donnell Rockefeller University
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Cees Dekker
Cees Dekker Delft University of Technology

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