World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
26971
World Ranking
2577
National Ranking
1349

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Hongtao Yu is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology. Other areas of study include Infectious Diseases, Immunology, Cell Biology, and Plant Science.

Their work covers several main topics spanning genomics and chromatin dynamics, RNA research and splicing, RNA and protein synthesis mechanisms, and SARS-CoV-2 and COVID-19 research. Additional topics explored include computational drug discovery methods, interferon and immune responses, as well as microtubule and mitosis dynamics.

Hongtao Yu has contributed to publications in various scientific venues. Frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), Cell Discovery, Nature Biomedical Engineering, Experimental & Molecular Medicine, and Nature.

  • Prolonged activation of innate immune pathways by a polyvalent STING agonist (2021, Nature Biomedical Engineering)
  • Cryo-EM structure of the human cohesin-NIPBL-DNA complex (2020, Science)
  • Insulin receptor endocytosis in the pathophysiology of insulin resistance (2020, Experimental & Molecular Medicine)
  • Structure of human GABAB receptor in an inactive state (2020, Nature)
  • Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro (2023, ACS Central Science)

The scientist frequently collaborates with several researchers. Notable co-authors include Zhubing Shi, Shu-Tao Qi, Haishan Gao, Bret M. Evers, and Chao Xing.

In recognition of contributions to science, Hongtao Yu was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Structural basis for the binding of proline-rich peptides to SH3 domains

    Hongtao Yu;James K. Chen;Sibo Feng;David C. Dalgarno

  • Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions.

    Sibo Feng;James K. Chen;Hongtao Yu;Julian A. Simon

  • Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.

    Sungyul Lee;Florian Kopp;Tsung Cheng Chang;Anupama Sataluri

  • The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

    Guowei Fang;Hongtao Yu;Hongtao Yu;Marc W. Kirschner

  • The spindle checkpoint, aneuploidy, and cancer

    Rajnish Bharadwaj;Hongtao Yu

  • Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

    Guowei Fang;Hongtao Yu;Marc W Kirschner

  • Human cohesin compacts DNA by loop extrusion

    Yoori Kim;Zhubing Shi;Hongshan Zhang;Ilya J. Finkelstein

  • SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

    Hyun Seok Kim;Athanassios Vassilopoulos;Rui Hong Wang;Tyler Lahusen

  • Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

    David A. Solomon;Taeyeon Kim;Laura A. Diaz-Martinez;Joshlean Fair

  • Mad2-Independent Inhibition of APCCdc20 by the Mitotic Checkpoint Protein BubR1

    Zhanyun Tang;Rajnish Bharadwaj;Bing Li;Hongtao Yu

  • Regulation of APC-Cdc20 by the spindle checkpoint.

    Hongtao Yu

  • Solution structure of the SH3 domain of Src and identification of its ligand-binding site

    Hongtao Yu;Michael K. Rosen;Tae Bum Shin;Cynthia Seidel-Dugan

  • The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

    Patrick Ryan Potts;Hongtao Yu

  • Cdc20: a WD40 activator for a cell cycle degradation machine.

    Hongtao Yu

  • The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad1 or Cdc20

    Xuelian Luo;Zhanyun Tang;Josep Rizo;Hongtao Yu

  • PP2A Is Required for Centromeric Localization of Sgo1 and Proper Chromosome Segregation

    Zhanyun Tang;Hongjun Shu;Wei Qi;Nadir A. Mahmood

  • Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase

    Maojun Yang;Christian B. Gocke;Xuelian Luo;Dominika Borek

  • The Mad2 spindle checkpoint protein has two distinct natively folded states.

    Xuelian Luo;Zhanyun Tang;Guohong Xia;Katja Wassmann

  • Phosphorylation of Cdc20 by Bub1 Provides a Catalytic Mechanism for APC/C Inhibition by the Spindle Checkpoint

    Zhanyun Tang;Hongjun Shu;Dilhan Oncel;She Chen

  • Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

    Hongtao Yu;Jan Michael Peters;Jan Michael Peters;Randall W. King;Randall W. King;Andrew M. Page;Andrew M. Page

Frequent Co-Authors

Bing Li
Bing Li Shanghai Jiao Tong University
Diana R. Tomchick
Diana R. Tomchick The University of Texas Southwestern Medical Center
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Mischa Machius
Mischa Machius The University of Texas Southwestern Medical Center
Zarife Sahenk
Zarife Sahenk Nationwide Children's Hospital
Josep Rizo
Josep Rizo The University of Texas Southwestern Medical Center
Chad A. Brautigam
Chad A. Brautigam The University of Texas Southwestern Medical Center
Marc W. Kirschner
Marc W. Kirschner Harvard University
Joshua T. Mendell
Joshua T. Mendell The University of Texas Southwestern Medical Center
Yang Xie
Yang Xie The University of Texas Southwestern Medical Center

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