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Biology and Biochemistry

D-Index
56
Citations
11785
World Ranking
14391
National Ranking
6060

Overview

Zarife Sahenk is affiliated with Nationwide Children's Hospital in the United States. Their research focuses primarily on neuromuscular disorders and gene therapy, contributing extensively to the fields of medicine and biochemistry, genetics, and molecular biology. The scientist's body of work includes 44 publications in Medicine and 41 publications related to Biochemistry, Genetics and Molecular Biology.

The research spans various subfields with particular emphasis on molecular biology, genetics, cellular and molecular neuroscience, neurology, and physiology. The distribution of their work includes 28 publications in Molecular Biology, 13 in Genetics, 9 in Cellular and Molecular Neuroscience, 9 in Neurology, and 6 in Physiology.

The scientific contributions cover major topics such as muscle physiology and disorders, virus-based gene therapy research, CAR-T cell therapy research, viral infections and immunology research, neurogenetic and muscular disorders research, hereditary neurological disorders, and tissue engineering and regenerative medicine. The frequency of publication on these topics includes 38 works on Muscle Physiology and Disorders, 18 on Virus-based Gene Therapy Research, 10 on CAR-T Cell Therapy Research, 8 on both Viral Infections and Immunology Research and Hereditary Neurological Disorders, and 6 on Tissue Engineering and Regenerative Medicine.

Some of the recent papers authored or coauthored by Zarife Sahenk include:

  • Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy, 2020, JAMA Neurology
  • Expression of SRP-9001 dystrophin and stabilization of motor function up to 2 years post-treatment with delandistrogene moxeparvovec gene therapy in individuals with Duchenne muscular dystrophy, 2023, Frontiers in Cell and Developmental Biology
  • Long-term safety and functional outcomes of delandistrogene moxeparvovec gene therapy in patients with Duchenne muscular dystrophy: A phase 1/2a nonrandomized trial, 2023, Muscle & Nerve
  • AAV1.NT-3 gene therapy for X-linked Charcot-Marie-Tooth neuropathy type 1, 2021, Gene Therapy
  • Unmet Needs and Evolving Treatment for Limb Girdle Muscular Dystrophies, 2021, Neurodegenerative Disease Management

The scientist frequently collaborates with other researchers. Their frequent coauthors include Kelly J. Lehman, M. Iammarino, Lindsay N. Alfano, Rachael A. Potter, and Linda Lowes.

Zarife Sahenk's work is often published in specialized venues with a focus on neuromuscular and neurological disorders. Frequent publication venues include:

  • Neuromuscular Disorders
  • Neurology
  • Gene Therapy
  • Brain Communications
  • JAMA Neurology

Best Publications

  • Dystrophin Immunity in Duchenne's Muscular Dystrophy

    Jerry R. Mendell;Katherine Campbell;Katherine Campbell;Louise Rodino-Klapac;Louise Rodino-Klapac;Zarife Sahenk;Zarife Sahenk

  • Myoblast Transfer in the Treatment of Duchenne's Muscular Dystrophy

    Jerry R. Mendell;John T. Kissel;Anthony A. Amato;Wendy King

  • Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

    Swarnali Acharyya;S. Armando Villalta;Nadine Bakkar;Tepmanas Bupha-Intr

  • Sustained Alpha-Sarcoglycan Gene Expression after Gene Transfer in Limb- Girdle Muscular Dystrophy, Type 2D

    Jerry R. Mendell;Jerry R. Mendell;Louise R. Rodino-Klapac;Louise R. Rodino-Klapac;Xiomara Q. Rosales;Brian D. Coley

  • Fatal infhntile mitochondrial myopathy and renal dysfunction due to cytochrome‐c‐oxidase deficiency

    Salvatore DiMauro;Jerry R. Mendell;Zarife Sahenk;David Bachman

  • A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

    Jerry R Mendell;Jerry R Mendell;Zarife Sahenk;Zarife Sahenk;Vinod Malik;Ana M Gomez

  • Limb-girdle muscular dystrophy type 2D gene therapy restores α-sarcoglycan and associated proteins

    Jerry R. Mendell;Louise R. Rodino-Klapac;Louise R. Rodino-Klapac;Louise R. Rodino-Klapac;Xiomara Rosales-Quintero;Xiomara Rosales-Quintero;Xiomara Rosales-Quintero;Janaiah Kota;Janaiah Kota;Janaiah Kota

  • Polyneuropathy and IgM monoclonal gammopathy: Studies on the pathogenetic role of anti‐myelin‐associated glycoprotein antibody

    J R Mendell;Z Sahenk;J N Whitaker;B D Trapp

  • Taxol Neuropathy: Electrodiagnostic and Sural Nerve Biopsy Findings

    Zarife Sahenk;Richard Barohn;Pamela New;Jerry R. Mendell

  • NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients

    Z. Sahenk;H. N. Nagaraja;B. S. McCracken;W. M. King

  • Gene therapy for muscular dystrophy: lessons learned and path forward.

    Jerry R. Mendell;Louise Rodino-Klapac;Zarife Sahenk;Vinod Malik

  • Heterophilic Binding of L1 on Unmyelinated Sensory Axons Mediates Schwann Cell Adhesion and Is Required for Axonal Survival

    C.A. Haney;C.A. Haney;Z. Sahenk;C. Li;V.P. Lemmon

  • Plasmapheresis Eliminates the Negative Impact of AAV Antibodies on Microdystrophin Gene Expression Following Vascular Delivery

    LG Chicoine;LG Chicoine;LG Chicoine;CL Montgomery;WG Bremer;KM Shontz

  • Studies on the pathogenesis of vincristine‐induced neuropathy

    Zarife Sahenk;Scott T. Brady;Jerry R. Mendell

  • CNTF potentiates peripheral nerve regeneration.

    Zarife Sahenk;Jegatheesan Seharaseyon;Jerry R. Mendell

  • Effects of PMP22 duplication and deletions on the axonal cytoskeleton.

    Zarife Sahenk;Lei Chen;Jerry R. Mendell

  • Inclusion body myositis: Treatment with intravenous immunoglobulin

    A. A. Amato;R. J. Barohn;Carlayne E Jackson;E. J. Pappert

  • Follistatin Gene Therapy for Sporadic Inclusion Body Myositis Improves Functional Outcomes

    Jerry R. Mendell;Jerry R. Mendell;Zarife Sahenk;Zarife Sahenk;Samiah Al-Zaidy;Samiah Al-Zaidy;Louise R. Rodino-Klapac;Louise R. Rodino-Klapac

  • Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery.

    Louise R Rodino-Klapac;Louise R Rodino-Klapac;Chrystal L Montgomery;Chrystal L Montgomery;William G Bremer;William G Bremer;Kimberly M Shontz;Kimberly M Shontz

  • AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy.

    Zarife Sahenk;Gloria M. Galloway;Kelly Reed Clark;Kelly Reed Clark;Vinod Malik;Vinod Malik

Frequent Co-Authors

Jerry R. Mendell
Jerry R. Mendell The Ohio State University
Brian K. Kaspar
Brian K. Kaspar Insmed Incorporated
Kevin M. Flanigan
Kevin M. Flanigan The Ohio State University
Christopher M. Walker
Christopher M. Walker The Ohio State University
John T. Kissel
John T. Kissel The Ohio State University
Anthony A. Amato
Anthony A. Amato Claude Bernard University Lyon 1
Richard J. Barohn
Richard J. Barohn University of Missouri
Julie M. Gastier-Foster
Julie M. Gastier-Foster Baylor College of Medicine
Joshua T. Mendell
Joshua T. Mendell The University of Texas Southwestern Medical Center
George A. Marzluf
George A. Marzluf The Ohio State University

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