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Molecular Biology

D-Index
68
Citations
20689
World Ranking
1501
National Ranking
762

Overview

Denis C. Guttridge is affiliated with the Medical University of South Carolina in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with particular attention to molecular biology, physiology, oncology, cancer research, and rheumatology as subfields.

The scientist's work addresses key topics such as nutrition and health in aging, muscle physiology and disorders, GDF15 and related biomarkers, pancreatic and hepatic oncology research, immune cells in cancer, microRNA in disease regulation, and sarcoma diagnosis and treatment.

Recent papers authored or co-authored by Denis C. Guttridge include:

  • Emerging signaling mediators in the anorexia-cachexia syndrome of cancer (2022, Trends in Cancer)
  • STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer (2022, Life Science Alliance)
  • Extracellular vesicles derived from tumour cells as a trigger of energy crisis in the skeletal muscle (2021, Journal of Cachexia Sarcopenia and Muscle)
  • Cancer cachexia: involvement of an expanding macroenvironment (2023, Cancer Cell)
  • Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia (2024, Cell Reports)

Their frequent co-authors include:

  • Teresa A. Zimmers
  • Erin E. Talbert
  • Michael C. Ostrowski
  • David J. Wang
  • Benjamin R. Pryce

Denis C. Guttridge's publications often appear in venues such as UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Cell Reports, and the Journal of Clinical Oncology.

Best Publications

  • NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

    Denis C. Guttridge;Chris Albanese;Julie Y. Reuther;Richard G. Pestell

  • Cancer-associated cachexia

    Vickie E. Baracos;Lisa Martin;Murray Korc;Denis C. Guttridge

  • Cancer cachexia: mediators, signaling, and metabolic pathways.

    Kenneth C.H. Fearon;David J. Glass;Denis C. Guttridge

  • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB

    Lee V. Madrid;Cun Yu Wang;Denis C. Guttridge;Arndt J G Schottelius

  • NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

    Cun Yu Wang;Denis C. Guttridge;Marty W. Mayo;Albert S. Baldwin

  • NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

    Huating Wang;Ramiro Garzon;Hao Sun;Katherine J. Ladner

  • Cancer cachexia is regulated by selective targeting of skeletal muscle gene products

    Unknown

  • Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

    Swarnali Acharyya;S. Armando Villalta;Nadine Bakkar;Tepmanas Bupha-Intr

  • NF-κB inhibition delays DNA damage–induced senescence and aging in mice

    Jeremy S. Tilstra;Andria R. Robinson;Jin Wang;Siobhán Q. Gregg

  • Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation

    Courtney Nicholas;Sanjay Batra;Melissa A. Vargo;Oliver H. Voss

  • Role for Activating Transcription Factor 3 in Stress-Induced β-Cell Apoptosis

    Matthew G. Hartman;Dan Lu;Mi Lyang Kim;Gary J. Kociba

  • Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.

    Swarnali Acharyya;Matthew E.R. Butchbach;Zarife Sahenk;Huating Wang

  • NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.

    Wei A. He;Emanuele Berardi;Veronica M. Cardillo;Swarnali Acharyya

  • Tumor Necrosis Factor-regulated Biphasic Activation of NF-κB Is Required for Cytokine-induced Loss of Skeletal Muscle Gene Products

    Katherine J. Ladner;Michael A. Caligiuri;Denis C. Guttridge

  • NF-κB Regulation of YY1 Inhibits Skeletal Myogenesis through Transcriptional Silencing of Myofibrillar Genes

    Huating Wang;Erin Hertlein;Nadine Bakkar;Hao Sun

  • Inflammation induced loss of skeletal muscle

    Unknown

  • DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo.

    Lindsay M. Wallace;Sara E. Garwick;Wenyan Mei;Wenyan Mei;Alexandra Belayew

  • Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis

    Zongbing You;Daniel Saims;Shaoqiong Chen;Zhaocheng Zhang

  • NF-κB Signaling: A Tale of Two Pathways in Skeletal Myogenesis

    Unknown

  • IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis

    Nadine Bakkar;Jingxin Wang;Katherine J. Ladner;Huating Wang

Frequent Co-Authors

Cheryl A. London
Cheryl A. London Tufts University
Kenneth C. H. Fearon
Kenneth C. H. Fearon University of Edinburgh
Peter J. Houghton
Peter J. Houghton The University of Texas Health Science Center at San Antonio
Albert S. Baldwin
Albert S. Baldwin University of North Carolina at Chapel Hill
Gustavo Leone
Gustavo Leone Medical University of South Carolina
Sandya Liyanarachchi
Sandya Liyanarachchi The Ohio State University
Michael C. Ostrowski
Michael C. Ostrowski Medical University of South Carolina
Carlo M. Croce
Carlo M. Croce The Ohio State University
Hao Sun
Hao Sun Chinese University of Hong Kong

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