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Genetics

D-Index
98
Citations
37680
World Ranking
806
National Ranking
405

Molecular Biology

D-Index
98
Citations
37680
World Ranking
571
National Ranking
313

Overview

Stephen J. Tapscott is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology and related subfields. Additional areas of study include Biomedical Engineering, Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, and Genetics.

The main topics covered in their work involve Muscle Physiology and Disorders, RNA Research and Splicing, RNA modifications and cancer, Genetic Neurodegenerative Diseases, Cardiomyopathy and Myosin Studies, Muscle activation and electromyography studies, and CRISPR and Genetic Engineering.

Frequent publication venues for Tapscott's work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Human Molecular Genetics
  • Scientific Reports
  • Neuromuscular Disorders
  • Nature Cell Biology

They have collaborated extensively with co-authors such as Silvère M. van der Maarel, Rabi Tawil, Seth D. Friedman, Jeffrey Statland, and Leo H. Wang.

Some of their recent papers illustrate a focus on muscular dystrophy, cancer biology, and molecular mechanisms involving RNA expression and oxidative stress. Selected publications include:

  • Longitudinal measures of RNA expression and disease activity in FSHD muscle biopsies (2020, Human Molecular Genetics)
  • Facioscapulohumeral muscular dystrophy: the road to targeted therapies (2023, Nature Reviews Neurology)
  • Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells (2022, Nature Cell Biology)
  • Longitudinal study of MRI and functional outcome measures in facioscapulohumeral muscular dystrophy (2021, BMC Musculoskeletal Disorders)
  • Systemic delivery of a DUX4-targeting antisense oligonucleotide to treat facioscapulohumeral muscular dystrophy (2021, Molecular Therapy - Nucleic Acids)

Best Publications

  • The myoD gene family: nodal point during specification of the muscle cell lineage

    Harold Weintraub;Robert Davis;Stephen Tapscott;Matthew Thayer

  • Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

    H Weintraub;S J Tapscott;R L Davis;M J Thayer

  • MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

    Stephen J. Tapscott;Robert L. Davis;Mathew J. Thayer;Pei Feng Cheng

  • The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription.

    Stephen J. Tapscott

  • MyoD and the transcriptional control of myogenesis

    Charlotte A. Berkes;Stephen J. Tapscott

  • Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease

    Ruth Luthi-Carter;Andrew Strand;Nikki L. Peters;Steven M. Solano

  • A Unifying Genetic Model for Facioscapulohumeral Muscular Dystrophy

    Richard J. L. F. Lemmers;Patrick J. van der Vliet;Rinse Klooster;Sabrina Sacconi

  • Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2

    Richard J.L.F. Lemmers;Rabi Tawil;Lisa M. Petek;Judit Balog

  • Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

    Peter G. Hendrickson;Jessie A. Doráis;Edward J. Grow;Jennifer L. Whiddon

  • Positive autoregulation of the myogenic determination gene MyoD1.

    Mathew J. Thayer;Stephen J. Tapscott;Stephen J. Tapscott;Robert L. Davis;Robert L. Davis;Woodring E. Wright

  • Generation of neurons by transient expression of neural bHLH proteins in mammalian cells

    Mohamed H. Farah;James M. Olson;Holly B. Sucic;Richard I. Hume

  • Functional antagonism between c-Jun and MyoD proteins: A direct physical association

    Eyal Bengal;Lynn Ransone;Raphael Scharfmann;V.J. Dwarki

  • Genome-wide MyoD Binding in Skeletal Muscle Cells: A Potential for Broad Cellular Reprogramming

    Yi Cao;Zizhen Yao;Deepayan Sarkar;Michael Lawrence

  • Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene

    Lauren Snider;Linda N. Geng;Richard J. L. F. Lemmers;Michael Kyba

  • Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

    Olga Klezovitch;Tania E. Fernandez;Stephen J. Tapscott;Valeri Vasioukhin

  • DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy

    Linda N. Geng;Zizhen Yao;Lauren Snider;Abraham P. Fong

  • Promoter-Specific Regulation of MyoD Binding and Signal Transduction Cooperate to Pattern Gene Expression

    Donald A. Bergstrom;Bennett H. Penn;Andrew Strand;Robert L.S. Perry

  • Muscle-specific transcriptional activation by MyoD.

    H Weintraub;V J Dwarki;I Verma;R Davis

  • Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

    Ruth Luthi-Carter;Sarah A. Hanson;Andrew D. Strand;Donald A. Bergstrom

  • MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206.

    Miriam I. Rosenberg;Sara A. Georges;Amy Asawachaicharn;Erwin Analau

Frequent Co-Authors

Rabi Tawil
Rabi Tawil University of Rochester Medical Center
Silvère M. van der Maarel
Silvère M. van der Maarel Leiden University Medical Center
Zizhen Yao
Zizhen Yao Allen Institute for Brain Science
Rainer Storb
Rainer Storb Fred Hutchinson Cancer Research Center
James M. Olson
James M. Olson Fred Hutchinson Cancer Research Center
Harold Weintraub
Harold Weintraub Fred Hutchinson Cancer Research Center
Jeffrey S. Chamberlain
Jeffrey S. Chamberlain University of Washington
Meng-Chao Yao
Meng-Chao Yao Academia Sinica
Andrew B. Lassar
Andrew B. Lassar Harvard University
F. Jeffrey Dilworth
F. Jeffrey Dilworth University of Wisconsin–Madison

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