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Molecular Biology

D-Index
71
Citations
17002
World Ranking
1381
National Ranking
702

Overview

Anthony N. Imbalzano is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on the intersection of biochemistry, genetics, and molecular biology, with a strong emphasis on molecular biology as reflected in the volume of their work.

Their studies cover several specialized areas within these broader fields, including:

  • Genomics and Chromatin Dynamics
  • Chromatin Remodeling and Cancer
  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Cancer Mechanisms and Therapy
  • RNA modifications and cancer

Much of Imbalzano's scientific output has appeared in frequent publication venues such as bioRxiv (Cold Spring Harbor Laboratory), where they have five publications, as well as Results and Problems in Cell Differentiation, International Journal of Molecular Sciences, Advanced Science, and Nucleic Acids Research.

Their recent papers include:

  • Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues (2020) published in Advanced Science
  • The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation (2021) published in Nucleic Acids Research
  • CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis (2020) published in International Journal of Molecular Sciences
  • Differential requirements for different subfamilies of the mammalian SWI/SNF chromatin remodeling enzymes in myoblast cell cycle progression and expression of the Pax7 regulator (2022) published in Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • PRMT5 links lipid metabolism to contractile function of skeletal muscles (2023) published in EMBO Reports

Collaborations have been a significant part of Imbalzano's research activities. Frequent co-authors include:

  • Teresita Padilla-Benavides
  • Sabriya A. Syed
  • Tapan Sharma
  • Monserrat Olea-Flores
  • Hanna Witwicka

Their work spans intricate mechanisms of chromatin remodeling, epigenetic regulation, and metabolic processes connected to cellular function and differentiation. The integration of these topics situates their research at crucial intersections of genetic regulation and disease mechanisms, particularly in cancer and muscle physiology.

Best Publications

  • Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

    Hyockman Kwon;Anthony N. Imbalzano;Paul A. Khavari;Robert E. Kingston

  • Facilitated binding of TATA-binding protein to nucleosomal DNA

    Anthony N. Imbalzano;Hyockman Kwon;Michael R. Green;Robert E. Kingston

  • Repression and activation by multiprotein complexes that alter chromatin structure.

    R E Kingston;C A Bunker;A N Imbalzano

  • RNA Polymerase II Holoenzyme Contains SWI/SNF Regulators Involved in Chromatin Remodeling

    Christopher J Wilson;David M Chao;Anthony N Imbalzano;Gavin R Schnitzler

  • The Chd family of chromatin remodelers.

    Concetta G.A. Marfella;Anthony N. Imbalzano

  • Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.

    Vladimir R. Ramirez-Carrozzi;Aaron A. Nazarian;Caiyi C. Li;Sarah L. Gore

  • p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.

    Cristiano Simone;Sonia Vanina Forcales;David A Hill;Anthony N Imbalzano

  • Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers.

    Ivana L. de la Serna;Yasuyuki Ohkawa;Anthony N. Imbalzano

  • Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice

    Cynthia J. Guidi;Arthur T. Sands;Brian P. Zambrowicz;Tod K. Turner

  • Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.

    Ivana L. de la Serna;Kerri A. Carlson;Anthony N. Imbalzano

  • Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes

    Saïd Sif;Andrew J. Saurin;Anthony N. Imbalzano;Robert E. Kingston

  • BRG-1 is required for RB-mediated cell cycle arrest

    Matthew W. Strobeck;Karen E. Knudsen;Anne F. Fribourg;Marc F. DeCristofaro

  • MyoD Targets Chromatin Remodeling Complexes to the Myogenin Locus Prior to Forming a Stable DNA-Bound Complex

    Ivana L. de la Serna;Yasuyuki Ohkawa;Charlotte A. Berkes;Donald A. Bergstrom;Donald A. Bergstrom

  • Versatility of PRMT5-induced methylation in growth control and development

    Vrajesh Karkhanis;Yu-Jie Hu;Robert A. Baiocchi;Anthony N. Imbalzano

  • Mammalian SWI/SNF complexes facilitate DNA double‐strand break repair by promoting γ‐H2AX induction

    Ji Hye Park;Eun Jung Park;Han Sae Lee;So Jung Kim

  • Activator-dependent regulation of transcriptional pausing on nucleosomal templates.

    S A Brown;A N Imbalzano;R E Kingston

  • Temporal Recruitment of Transcription Factors and SWI/SNF Chromatin-Remodeling Enzymes during Adipogenic Induction of the Peroxisome Proliferator-Activated Receptor γ Nuclear Hormone Receptor

    Nunciada Salma;Hengyi Xiao;Elisabetta Mueller;Anthony N. Imbalzano

  • Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2

    Daniel W. Young;Mohammad Q. Hassan;Jitesh Pratap;Mario Galindo;Mario Galindo

  • Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

    Rajini R. Mudhasani;Zhiqing Zhu;Gyorgy Hutvagner;Christine M. Eischen

  • Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells

    A. Rasim Barutcu;Bryan R. Lajoie;Rachel P. McCord;Coralee E. Tye

Frequent Co-Authors

Gary S. Stein
Gary S. Stein University of Vermont
Jane B. Lian
Jane B. Lian University of Vermont
Janet L. Stein
Janet L. Stein University of Vermont
Jeffrey A. Nickerson
Jeffrey A. Nickerson University of Massachusetts Chan Medical School
Yasuyuki Ohkawa
Yasuyuki Ohkawa Kyushu University
Stephen N. Jones
Stephen N. Jones University of Massachusetts Chan Medical School
Sayyed K. Zaidi
Sayyed K. Zaidi University of Vermont
Andre J. Van Wijnen
Andre J. Van Wijnen University of Connecticut Health Center
Martin Montecino
Martin Montecino Andrés Bello University
Robert E. Kingston
Robert E. Kingston Harvard University

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