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D-Index & Metrics

Microbiology

D-Index
60
Citations
11381
World Ranking
3162
National Ranking
1252

Overview

Neal A. DeLuca is affiliated with the University of Pittsburgh in the United States. Their research spans several fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Agricultural and Biological Sciences. Within these areas, their work addresses subfields such as Epidemiology, Plant Science, Molecular Biology, Endocrinology, and Cardiology and Cardiovascular Medicine.

DeLuca's research topics emphasize viral infections and immune responses, notably focusing on:

  • Herpesvirus Infections and Treatments
  • Plant Virus Research Studies
  • Plant and Fungal Interactions Research
  • Cytomegalovirus and herpesvirus research
  • Viral Infections and Immunology Research
  • Interferon and immune responses
  • RNA Research and Splicing

Their recent scientific publications demonstrate an engagement with viral molecular biology and host interactions. Selected recent papers include:

  • "Manipulation of RNA Polymerase III by Herpes Simplex Virus-1," 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • "Manipulation of RNA polymerase III by Herpes Simplex Virus-1," 2022, Nature Communications
  • "Antiviral Properties of the LSD1 Inhibitor SP-2509," 2020, Journal of Virology
  • "New model integrates innate responses, PML-NB formation, epigenetic control and reactivation from latency," 2021, EMBO Reports
  • "Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1," 2024, Immunology

Frequent coauthors working alongside DeLuca include Sarah E. Dremel, Frances L. Sivrich, Jessica M. Tucker, Britt A. Glaunsinger, and Mitchell R. Harancher.

The venues where DeLuca's work appears are diverse and include Nature Communications, Journal of Virology, bioRxiv (Cold Spring Harbor Laboratory), EMBO Reports, and Immunology.

Best Publications

  • Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4.

    N. A. DeLuca;Ann Marie McCarthy;P. A. Schaffer

  • Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins

    Lorna A. Samaniego;Lisa Neiderhiser;Neal A. DeLuca

  • Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

    Megan H. Orzalli;Neal A. DeLuca;David M. Knipe

  • Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4.

    N A DeLuca;P A Schaffer

  • PERTURBATION OF CELL CYCLE PROGRESSION AND CELLULAR GENE EXPRESSION AS A FUNCTION OF HERPES SIMPLEX VIRUS ICP0

    William E. Hobbs;Neal A. DeLuca

  • Herpes Simplex Virus 1 Has Multiple Mechanisms for Blocking Virus-Induced Interferon Production

    Gregory T. Melroe;Neal A. DeLuca;David M. Knipe

  • The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27.

    L A Samaniego;N Wu;N A DeLuca

  • Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides

    Neal A. DeLuca;Priscilla A. Schaffer

  • Development and application of herpes simplex virus vectors for human gene therapy

    J C Glorioso;N A DeLuca;D J Fink

  • ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.

    C. A. Smith;P. Bates;R. Rivera-Gonzalez;Baohua Gu

  • Gene transfer to neurons using herpes simplex virus-based vectors.

    D J Fink;N A DeLuca;W F Goins;J C Glorioso

  • Expression of Herpes Simplex Virus ICP0 Inhibits the Induction of Interferon-Stimulated Genes by Viral Infection

    Kasey M. Eidson;William E. Hobbs;Brian J. Manning;Paul Carlson

  • Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22.

    N Wu;S C Watkins;P A Schaffer;N A DeLuca

  • Localization and Membrane Topology of Coronavirus Nonstructural Protein 4: Involvement of the Early Secretory Pathway in Replication

    Unknown

  • Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4.

    L A Samaniego;A L Webb;N A DeLuca

  • Relationship of herpes simplex virus genome configuration to productive and persistent infections

    Sara A. Jackson;Neal A. DeLuca

  • Interaction of the Viral Activator Protein ICP4 with TFIID through TAF250.

    M J Carrozza;N A DeLuca

  • Nucleotide sequence specifying the glycoprotein gene, gB, of herpes simplex virus type 1.

    Unknown

  • Mutations in herpes simplex virus type 1 genes encoding VP5 and VP23 abrogate capsid formation and cleavage of replicated DNA.

    P Desai;N A DeLuca;J C Glorioso;S Person

  • Herpes simplex virus type 1 VP26 is not essential for replication in cell culture but influences production of infectious virus in the nervous system of infected mice.

    Prashant Desai;Neal A. DeLuca;Stanley Person

  • Activation of human immunodeficiency virus by herpes simplex virus.

    Marjorie P. Golden;Sunyoung Kim;Scott M. Hammer;Elizabeth A. Ladd

  • Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4.

    A A Shepard;A N Imbalzano;N A DeLuca

Frequent Co-Authors

Joseph C. Glorioso
Joseph C. Glorioso University of Pittsburgh
David M. Knipe
David M. Knipe Harvard University
Anthony N. Imbalzano
Anthony N. Imbalzano University of Massachusetts Chan Medical School
William F. Goins
William F. Goins University of Pittsburgh
Donald M. Coen
Donald M. Coen Harvard University
Sandra K. Weller
Sandra K. Weller University of Connecticut
Clayton A. Wiley
Clayton A. Wiley University of Pittsburgh
Priscilla A. Schaffer
Priscilla A. Schaffer Beth Israel Deaconess Medical Center
Sean P. J. Whelan
Sean P. J. Whelan Washington University in St. Louis

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