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Biology and Biochemistry

D-Index
72
Citations
20030
World Ranking
6259
National Ranking
2939

Research.com Recognitions

  • 1997 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Clayton A. Wiley is affiliated with the University of Pittsburgh in the United States. Their research spans multiple fields, primarily focusing on medicine as well as biochemistry, genetics, and molecular biology. Wiley's work frequently intersects with subfields including molecular biology, genetics, immunology, oncology, and infectious diseases.

Wiley's recent published papers cover a range of topics related to neuroinflammation, viral infections, and genetic disorders. These publications include:

  • Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: The polyG diseases (2021, Neuron)
  • Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain (2021, Journal of Neuroinflammation)
  • An AGS-associated mutation in ADAR1 catalytic domain results in early-onset and MDA5-dependent encephalopathy with IFN pathway activation in the brain (2022, Journal of Neuroinflammation)
  • Emergent Viral Infections of the CNS (2020, Journal of Neuropathology & Experimental Neurology)
  • Multifocal Necrotizing Leukoencephalopathy With Preferential Microglia Toxicity in a Patient Treated With Chimeric Antigen Receptor T-Cells and Review of the Literature (2020, Journal of Neuropathology & Experimental Neurology)

Frequent co-authors include Richard A. Steinman, Qingde Wang, Xinfeng Guo, Sheng Yi, and Timothy R. Billiar. These collaborations highlight interdisciplinary research activities.

Wiley's work is published predominantly in several scientific venues, among which the following have been frequent publication sources:

  • Journal of Neuropathology & Experimental Neurology
  • Journal of Neuroinflammation
  • Brain Pathology
  • Neuron
  • Journal of Pathology Informatics

The main research topics addressed by Wiley include:

  • Interferon and immune responses
  • RNA research and splicing
  • RNA regulation and disease
  • Glioma diagnosis and treatment
  • Genetic neurodegenerative diseases
  • Genetics and neurodevelopmental disorders
  • Mosquito-borne diseases and control

Their work involves investigations into immune system activation, genetic mutations related to neurological diseases, and viral infections affecting the central nervous system. This breadth supports ongoing advancements in understanding mechanisms of disease at the molecular and genetic level.

Clayton A. Wiley was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1997.

Best Publications

  • Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients

    Clayton A. Wiley;Rachel D. Schrier;Jay A. Nelson;Peter W. Lampert

  • Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center.

    E Masliah;R K Heaton;T D Marcotte;R J Ellis

  • Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.

    M P Heyes;K Saito;S P Markey

  • High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients

    Shen Pang;Yoshio Koyanagi;Steven Miles;Clayton Wiley

  • HUMAN IMMUNODEFICIENCY VIRUS DETECTED IN BOWEL EPITHELIUM FROM PATIENTS WITH GASTROINTESTINAL SYMPTOMS

    Jay A. Nelson;Catherine Reynolds-Kohler;William Margaretten;Clayton A. Wiley

  • Chemokines and receptors in HIV encephalitis.

    Virginia J. Sanders;Christopher A. Pittman;Michael G. White;Guoji Wang

  • HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology.

    Herbert Budka;Clayton A. Wiley;Paul Kleihues;Juan Artigas

  • The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging.

    Sriram Venneti;Brian J. Lopresti;Clayton A. Wiley

  • Brain Extracellular Matrix in Neurodegeneration

    Dafna Bonneh-Barkay;Clayton A. Wiley

  • Haptoglobin polymorphism, iron metabolism and mortality in HIV infection.

    J R Delanghe;M R Langlois;J R Boelaert;J Van Acker

  • In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases

    Dafna Bonneh-Barkay;Guoji Wang;Adam Starkey;Ronald L Hamilton

  • Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome

    Clayton A. Wiley;Cristian Achim

  • Distribution of Brain HIV Load in AIDS

    Clayton A. Wiley;Virawudh Soontornniyomkij;Lakshmi Radhakrishnan;Eliezer Masliah

  • Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

    Alec J. Hirsch;Jessica L. Smith;Nicole N. Haese;Rebecca M. Broeckel

  • Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs.

    Lawrence F. Brass;Myles H. Akabas;Linda D. Burnley;David M. Engman

  • HIV and HCMV coinfect brain cells in patients with AIDS.

    Jay A. Nelson;Catherine Reynolds-Kohler;Michael B.A. Oldstone;Clayton A. Wiley

  • Psychostimulant Abuse and Neuroinflammation: Emerging Evidence of Their Interconnection

    Kenneth H. Clark;Clayton A. Wiley;Charles W. Bradberry

  • Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques

    Melvyn P. Heyes;Kuniaki Saito;Andrew Lackner;Clayton A. Wiley

  • Imaging Microglial Activation During Neuroinflammation and Alzheimer’s Disease

    Sriram Venneti;Clayton A. Wiley;Julia Kofler

  • Molecular imaging of microglia/macrophages in the brain.

    Sriram Venneti;Brian J. Lopresti;Clayton A. Wiley

Frequent Co-Authors

William R. Freeman
William R. Freeman University of California, San Diego
Michael Murphey-Corb
Michael Murphey-Corb University of Pittsburgh
Chester A. Mathis
Chester A. Mathis University of Pittsburgh
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Ted M. Ross
Ted M. Ross University of Georgia
Ronald L. Hamilton
Ronald L. Hamilton University of Pittsburgh
Craig Horbinski
Craig Horbinski Northwestern University
John W. Mellors
John W. Mellors University of Pittsburgh
Teresa G. Hastings
Teresa G. Hastings University of Pittsburgh
Jay A. Nelson
Jay A. Nelson Oregon Health & Science University

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