H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 64 Citations 19,460 255 World Ranking 4206 National Ranking 99

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Internal medicine

Quinolinic acid, Kynurenine pathway, Microglia, Immunology and Kynurenic acid are his primary areas of study. His Quinolinic acid study combines topics from a wide range of disciplines, such as Internal medicine, Pathogenesis, Endocrinology and Kynurenine. His Kynurenine pathway study combines topics in areas such as Astrocyte, Neuroinflammation, Cell biology, Pharmacology and Indoleamine 2,3-dioxygenase.

Gilles J. Guillemin focuses mostly in the field of Neuroinflammation, narrowing it down to matters related to Neuroprotection and, in some cases, Disease and Neurodegeneration. His biological study spans a wide range of topics, including ABCA7, ABCA8, ATP-binding cassette transporter, Gene expression and Neuroglia. His Kynurenic acid research integrates issues from Multiple sclerosis, Dementia and Kynureninase.

His most cited work include:

  • An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor (1047 citations)
  • Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification (444 citations)
  • Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification (444 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Kynurenine pathway, Quinolinic acid, Immunology, Biochemistry and Kynurenine. His Kynurenine pathway research includes themes of Kynurenic acid, Bioinformatics, Pathogenesis, Neuroinflammation and Indoleamine 2,3-dioxygenase. His Neuroinflammation research is multidisciplinary, incorporating perspectives in Neurodegeneration and Neuroscience.

The various areas that Gilles J. Guillemin examines in his Quinolinic acid study include Microglia, Neuroprotection, Pharmacology, Excitotoxicity and Cell biology. His studies in Cell biology integrate themes in fields like NMDA receptor and Molecular biology. The study incorporates disciplines such as Metabolite, Internal medicine and Endocrinology in addition to Kynurenine.

He most often published in these fields:

  • Kynurenine pathway (42.93%)
  • Quinolinic acid (34.77%)
  • Immunology (22.06%)

What were the highlights of his more recent work (between 2017-2021)?

  • Kynurenine pathway (42.93%)
  • Kynurenine (20.14%)
  • Pharmacology (18.47%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Kynurenine pathway, Kynurenine, Pharmacology, Cell biology and Neuroprotection. His Kynurenine pathway research includes elements of Biomarker, Neuroinflammation, Kynurenic acid and Bioinformatics. The concepts of his Kynurenine study are interwoven with issues in Endocrinology, Inflammation, Internal medicine, Pathogenesis and Quinolinic acid.

Gilles J. Guillemin carries out multidisciplinary research, doing studies in Quinolinic acid and Population. His Pharmacology research includes themes of Viability assay, Memantine, Signal transduction and Chronic pain. His research in Neuroprotection intersects with topics in Oxidative stress, Neurotoxicity, Sphingosine, Sphingosine-1-phosphate and Neurodegeneration.

Between 2017 and 2021, his most popular works were:

  • Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia (58 citations)
  • Dendritic spines: Revisiting the physiological role (43 citations)
  • Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma (42 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

Gilles J. Guillemin mostly deals with Kynurenine, Kynurenine pathway, Internal medicine, Neuroprotection and Neurotoxicity. His Kynurenine research integrates issues from Cytokine, Indoleamine 2,3-dioxygenase, Quinolinic acid, Cell biology and Candidate gene. Gilles J. Guillemin combines subjects such as SH-SY5Y, Transcriptome and NAD+ kinase with his study of Quinolinic acid.

His work carried out in the field of Kynurenine pathway brings together such families of science as Kynurenic acid, Case-control study, Neopterin, Serotonin and Alzheimer's disease. While the research belongs to areas of Internal medicine, Gilles J. Guillemin spends his time largely on the problem of Endocrinology, intersecting his research to questions surrounding Pathogenesis. His Neuroprotection research is classified as research in Pharmacology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Christiane A. Opitz;Ulrike M. Litzenburger;Ulrike M. Litzenburger;Felix Sahm;Martina Ott.
Nature (2011)

1305 Citations

Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification

Gilles J. Guillemin;Gilles J. Guillemin;Bruce J. Brew.
Journal of Leukocyte Biology (2004)

632 Citations

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

Johann Steiner;Johann Steiner;Martin Walter;Tomasz Gos;Tomasz Gos;Gilles J Guillemin.
Journal of Neuroinflammation (2011)

522 Citations

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

Nady Braidy;Gilles J. Guillemin;Hussein Mansour;Tailoi Chan-Ling.
PLOS ONE (2011)

492 Citations

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States:

Yiquan Chen;Gilles J. Guillemin.
International Journal of Tryptophan Research (2009)

465 Citations

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Alban Bessede;Alban Bessede;Marco Gargaro;Maria T. Pallotta;Davide Matino.
Nature (2014)

457 Citations

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

Gilles J. Guillemin;Stephen J. Kerr;George A. Smythe;Danielle G. Smith.
Journal of Neurochemistry (2001)

453 Citations

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.

Gilles J. Guillemin;Gilles J. Guillemin;George Smythe;Osamu Takikawa;Bruce J. Brew;Bruce J. Brew.
Glia (2005)

443 Citations

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.

Hassina Massudi;Ross Grant;Ross Grant;Nady Braidy;Jade Guest;Jade Guest.
PLOS ONE (2012)

366 Citations

Quinolinic acid, the inescapable neurotoxin.

Gilles J. Guillemin;Gilles J. Guillemin.
FEBS Journal (2012)

330 Citations

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