World's Best Scientists 2026 revealed!
David A. Sinclair

David A. Sinclair

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
101834
World Ranking
618
National Ranking
394

David A. Sinclair publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where David A. Sinclair sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 420 publications — 91st percentile

91% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

David A. Sinclair D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where David A. Sinclair sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 120 D-Index — 97th percentile

97% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2003 - Fellow of the Royal Society of Canada Academy of Science

Overview

David A. Sinclair is affiliated with Harvard University in the United States. Their research focuses on areas within Medicine and Biochemistry, Genetics and Molecular Biology, with a substantial number of publications in these fields.

The scientist's main fields of study include Medicine with 108 publications and Biochemistry, Genetics and Molecular Biology with 96 publications. Their work dives deeper into subfields such as Molecular Biology, Physiology, Geriatrics and Gerontology, Aging, and Cellular and Molecular Neuroscience.

The primary topics covered in their research are diverse. These include Genetics, Aging, and Longevity in Model Organisms; Sirtuins and Resveratrol in Medicine; Epigenetics and DNA Methylation; Adipose Tissue and Metabolism; Mitochondrial Function and Pathology; Diet and metabolism studies; and Frailty in Older Adults.

David A. Sinclair has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Aging, Nature Aging, Innovation in Aging, and Cell. The number of publications in these venues ranges from three to seventeen, indicating a strong presence in both preprint and peer-reviewed journals specializing in aging and cellular biology.

The scientist has collaborated closely with colleagues, the most frequent co-authors being Alice E. Kane, Sarah J. Mitchell, Xiao Tian, Daniel L. Vera, and Vadim N. Gladyshev.

Significant recent papers include:

  • "Why does COVID-19 disproportionately affect older people?", 2020, Aging
  • "Mitochondrial and metabolic dysfunction in ageing and age-related diseases", 2022, Nature Reviews Endocrinology
  • "Reprogramming to recover youthful epigenetic information and restore vision", 2020, Nature
  • "Loss of epigenetic information as a cause of mammalian aging", 2023, Cell
  • "NAD+ Repletion Rescues Female Fertility during Reproductive Aging", 2020, Cell Reports

David A. Sinclair was recognized as a Fellow of the Royal Society of Canada in 2003 for contributions to the Academy of Science.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Resveratrol improves health and survival of mice on a high-calorie diet

    Joseph A. Baur;Kevin J. Pearson;Nathaniel O Price;Hamish A. Jamieson

  • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

    Konrad T. Howitz;Kevin J. Bitterman;Haim Y. Cohen;Dudley W. Lamming

  • Therapeutic potential of resveratrol: the in vivo evidence.

    Joseph A. Baur;David A. Sinclair

  • Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

    Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua

  • GRADE guidelines: 6. Rating the quality of evidence-imprecision

    Gordon H. Guyatt;Andrew D. Oxman;Regina Kunz;Jan Brozek

  • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

    Haim Y. Cohen;Christine Miller;Kevin J. Bitterman;Nathan R. Wall

  • Sirtuin activators mimic caloric restriction and delay ageing in metazoans

    Jason G. Wood;Blanka Rogina;Siva Lavu;Konrad Howitz

  • Mammalian sirtuins: biological insights and disease relevance.

    Marcia C. Haigis;David A. Sinclair

  • Sirtuins in mammals: insights into their biological function

    Shaday Michan;David A Sinclair

  • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

    Jill C. Milne;Philip D. Lambert;Simon Schenk;David P. Carney

  • Extrachromosomal rDNA circles--a cause of aging in yeast.

    David A Sinclair;Leonard Guarente

  • SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

    Nathan L. Price;Ana P. Gomes;Alvin J.Y. Ling;Filipe V. Duarte

  • Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

    Ana P. Gomes;Ana P. Gomes;Nathan L. Price;Alvin J.Y. Ling;Javid Moslehi

  • The Intersection Between Aging and Cardiovascular Disease

    Brian J. North;David A. Sinclair

  • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

    Kevin J. Pearson;Joseph A. Baur;Kaitlyn N. Lewis;Leonid Peshkin

  • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

    Dohoon Kim;Dohoon Kim;Minh Dang Nguyen;Matthew M. Dobbin;Andre Fischer

  • Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

    Kevin J. Bitterman;Rozalyn M. Anderson;Haim Y. Cohen;Magda Latorre-Esteves

  • The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication

    P. Bercik;A. J. Park;D. Sinclair;A. Khoshdel

  • Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

    Hongying Yang;Tianle Yang;Joseph A. Baur;Evelyn Perez

Frequent Co-Authors

Yuehe Lin
Yuehe Lin Washington State University
Rafael de Cabo
Rafael de Cabo National Institutes of Health
Michael Bonkowski
Michael Bonkowski University of Cologne
Joseph A. Baur
Joseph A. Baur University of Pennsylvania

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