H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 95 Citations 65,903 263 World Ranking 851 National Ranking 523

Research.com Recognitions

Awards & Achievements

2003 - Fellow of the Royal Society of Canada Academy of Science

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Internal medicine

NAD+ kinase, Sirtuin, Internal medicine, Sirtuin 1 and Endocrinology are his primary areas of study. The various areas that he examines in his NAD+ kinase study include Mitochondrion and Cell biology. David A. Sinclair combines subjects such as Ageing, Protein deacetylase, Transcription factor and Longevity with his study of Sirtuin.

Oxidative phosphorylation and Cell nucleus is closely connected to Glucose homeostasis in his research, which is encompassed under the umbrella topic of Sirtuin 1. His work carried out in the field of Endocrinology brings together such families of science as Inflammation, Resveratrol, SRT1720 and Mitochondrial biogenesis. His Resveratrol study incorporates themes from AMPK and Small molecule.

His most cited work include:

  • Resveratrol improves health and survival of mice on a high-calorie diet (3469 citations)
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3242 citations)
  • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (3024 citations)

What are the main themes of his work throughout his whole career to date?

David A. Sinclair focuses on NAD+ kinase, Internal medicine, Biochemistry, Cell biology and Sirtuin. He has researched NAD+ kinase in several fields, including Cofactor, Mitochondrion and Nicotinamide. His studies in Internal medicine integrate themes in fields like Endocrinology and Surgery.

His is involved in several facets of Biochemistry study, as is seen by his studies on Enzyme, Saccharomyces cerevisiae, Sirtuin 1 and Acetylation. The study incorporates disciplines such as Chromatin, Epigenetics and DNA damage in addition to Cell biology. His Sirtuin study frequently links to adjacent areas such as Resveratrol.

He most often published in these fields:

  • NAD+ kinase (27.47%)
  • Internal medicine (22.70%)
  • Biochemistry (20.65%)

What were the highlights of his more recent work (between 2016-2021)?

  • NAD+ kinase (27.47%)
  • Cell biology (18.77%)
  • Internal medicine (22.70%)

In recent papers he was focusing on the following fields of study:

David A. Sinclair mainly investigates NAD+ kinase, Cell biology, Internal medicine, Endocrinology and Nicotinamide mononucleotide. NAD+ kinase is a subfield of Biochemistry that David A. Sinclair explores. His Cell biology research incorporates elements of DNA damage, DNA methylation, Reprogramming, Chromatin and Epigenetics.

Endocrinology and Offspring are commonly linked in his work. The Nicotinamide mononucleotide study combines topics in areas such as Oxidative stress, Fertility, Nicotinamide riboside, Oocyte and Metabolism. His biological study spans a wide range of topics, including Mediator, Mitochondrion and Pharmacology.

Between 2016 and 2021, his most popular works were:

  • Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence (208 citations)
  • Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence (208 citations)
  • Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector (167 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

His primary scientific interests are in NAD+ kinase, Internal medicine, Endocrinology, Cell biology and Nicotinamide adenine dinucleotide. His study in NAD+ kinase focuses on Nicotinamide mononucleotide and Sirtuin. When carried out as part of a general Internal medicine research project, his work on Disease severity, Betacoronavirus and Pandemic is frequently linked to work in 2019-20 coronavirus outbreak, therefore connecting diverse disciplines of study.

The Calorie restriction, Low protein and Dentate gyrus research David A. Sinclair does as part of his general Endocrinology study is frequently linked to other disciplines of science, such as Dendritic spine and Barnes maze, therefore creating a link between diverse domains of science. His work deals with themes such as Reprogramming, Oxidative phosphorylation, Epigenetics and DNA methylation, which intersect with Cell biology. His study with Nicotinamide adenine dinucleotide involves better knowledge in Biochemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham.
Autophagy (2012)

7068 Citations

Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur;Kevin J. Pearson;Nathaniel O Price;Hamish A. Jamieson.
Nature (2006)

4816 Citations

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Konrad T. Howitz;Kevin J. Bitterman;Haim Y. Cohen;Dudley W. Lamming.
Nature (2003)

4332 Citations

Direct evidence for neutrino flavor transformation from neutral current interactions in the Sudbury Neutrino Observatory

Q. R. Ahmad;R. C. Allen;T. C. Andersen;J. D.Anglin.
Physical Review Letters (2002)

4262 Citations

Therapeutic potential of resveratrol: the in vivo evidence.

Joseph A. Baur;David A. Sinclair.
Nature Reviews Drug Discovery (2006)

4041 Citations

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua.
Science (2004)

3289 Citations

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Haim Y. Cohen;Christine Miller;Kevin J. Bitterman;Nathan R. Wall.
Science (2004)

2171 Citations

Measurement of the rate of ve + d → p + p + e- interactions produced by 8B solar neutrinos at the sudbury neutrino observatory

Q. R. Ahmad;R. C. Allen;T. C. Andersen;J. D. Anglin.
Physical Review Letters (2001)

2166 Citations

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Jason G. Wood;Blanka Rogina;Siva Lavu;Konrad Howitz.
Nature (2004)

2081 Citations

Mammalian sirtuins: biological insights and disease relevance.

Marcia C. Haigis;David A. Sinclair.
Annual Review of Pathology-mechanisms of Disease (2010)

1782 Citations

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