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David A. Sinclair

David A. Sinclair

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
101834
World Ranking
618
National Ranking
394

Research.com Recognitions

  • 2003 - Fellow of the Royal Society of Canada Academy of Science

Overview

David A. Sinclair is affiliated with Harvard University in the United States. Their research focuses on areas within Medicine and Biochemistry, Genetics and Molecular Biology, with a substantial number of publications in these fields.

The scientist's main fields of study include Medicine with 108 publications and Biochemistry, Genetics and Molecular Biology with 96 publications. Their work dives deeper into subfields such as Molecular Biology, Physiology, Geriatrics and Gerontology, Aging, and Cellular and Molecular Neuroscience.

The primary topics covered in their research are diverse. These include Genetics, Aging, and Longevity in Model Organisms; Sirtuins and Resveratrol in Medicine; Epigenetics and DNA Methylation; Adipose Tissue and Metabolism; Mitochondrial Function and Pathology; Diet and metabolism studies; and Frailty in Older Adults.

David A. Sinclair has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Aging, Nature Aging, Innovation in Aging, and Cell. The number of publications in these venues ranges from three to seventeen, indicating a strong presence in both preprint and peer-reviewed journals specializing in aging and cellular biology.

The scientist has collaborated closely with colleagues, the most frequent co-authors being Alice E. Kane, Sarah J. Mitchell, Xiao Tian, Daniel L. Vera, and Vadim N. Gladyshev.

Significant recent papers include:

  • "Why does COVID-19 disproportionately affect older people?", 2020, Aging
  • "Mitochondrial and metabolic dysfunction in ageing and age-related diseases", 2022, Nature Reviews Endocrinology
  • "Reprogramming to recover youthful epigenetic information and restore vision", 2020, Nature
  • "Loss of epigenetic information as a cause of mammalian aging", 2023, Cell
  • "NAD+ Repletion Rescues Female Fertility during Reproductive Aging", 2020, Cell Reports

David A. Sinclair was recognized as a Fellow of the Royal Society of Canada in 2003 for contributions to the Academy of Science.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Resveratrol improves health and survival of mice on a high-calorie diet

    Joseph A. Baur;Kevin J. Pearson;Nathaniel O Price;Hamish A. Jamieson

  • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

    Konrad T. Howitz;Kevin J. Bitterman;Haim Y. Cohen;Dudley W. Lamming

  • Therapeutic potential of resveratrol: the in vivo evidence.

    Joseph A. Baur;David A. Sinclair

  • Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

    Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua

  • GRADE guidelines: 6. Rating the quality of evidence-imprecision

    Gordon H. Guyatt;Andrew D. Oxman;Regina Kunz;Jan Brozek

  • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

    Haim Y. Cohen;Christine Miller;Kevin J. Bitterman;Nathan R. Wall

  • Sirtuin activators mimic caloric restriction and delay ageing in metazoans

    Jason G. Wood;Blanka Rogina;Siva Lavu;Konrad Howitz

  • Mammalian sirtuins: biological insights and disease relevance.

    Marcia C. Haigis;David A. Sinclair

  • Sirtuins in mammals: insights into their biological function

    Shaday Michan;David A Sinclair

  • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

    Jill C. Milne;Philip D. Lambert;Simon Schenk;David P. Carney

  • Extrachromosomal rDNA circles--a cause of aging in yeast.

    David A Sinclair;Leonard Guarente

  • SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

    Nathan L. Price;Ana P. Gomes;Alvin J.Y. Ling;Filipe V. Duarte

  • Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

    Ana P. Gomes;Ana P. Gomes;Nathan L. Price;Alvin J.Y. Ling;Javid Moslehi

  • The Intersection Between Aging and Cardiovascular Disease

    Brian J. North;David A. Sinclair

  • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

    Kevin J. Pearson;Joseph A. Baur;Kaitlyn N. Lewis;Leonid Peshkin

  • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

    Dohoon Kim;Dohoon Kim;Minh Dang Nguyen;Matthew M. Dobbin;Andre Fischer

  • Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

    Kevin J. Bitterman;Rozalyn M. Anderson;Haim Y. Cohen;Magda Latorre-Esteves

  • The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication

    P. Bercik;A. J. Park;D. Sinclair;A. Khoshdel

  • Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

    Hongying Yang;Tianle Yang;Joseph A. Baur;Evelyn Perez

Frequent Co-Authors

Yuehe Lin
Yuehe Lin Washington State University
Rafael de Cabo
Rafael de Cabo National Institutes of Health
Michael Bonkowski
Michael Bonkowski University of Cologne
Joseph A. Baur
Joseph A. Baur University of Pennsylvania

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