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Biology and Biochemistry

D-Index
73
Citations
38256
World Ranking
5789
National Ranking
2734

Overview

Joseph A. Baur is affiliated with the University of Pennsylvania in the United States. Their research spans multiple areas primarily within Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to molecular biology, physiology, geriatrics and gerontology, oncology, and epidemiology.

The scientist's recent notable papers include:

  • CAR T therapy beyond cancer: the evolution of a living drug (2023, Nature)
  • The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine (2021, Cell Metabolism)
  • Lactate Limits T Cell Proliferation via the NAD(H) Redox State (2020, Cell Reports)
  • CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels (2020, Nature Metabolism)
  • Role of NAD+ in regulating cellular and metabolic signaling pathways (2021, Molecular Metabolism)

The research work extensively covers key topics such as:

  • Mitochondrial Function and Pathology
  • Sirtuins and Resveratrol in Medicine
  • Adipose Tissue and Metabolism
  • Diet and metabolism studies
  • Genetics, Aging, and Longevity in Model Organisms
  • Calcium signaling and nucleotide metabolism
  • PARP inhibition in cancer therapy

Frequent collaboration plays a role in their work, with regular coauthors including:

  • Sarmistha Mukherjee
  • Karthikeyani Chellappa
  • Joshua D. Rabinowitz
  • James G. Davis
  • Paul M. Titchenell

Joseph A. Baur has published repeatedly in several venues, with multiple papers appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Metabolism
  • Nature Metabolism
  • Molecular Metabolism
  • Innovation in Aging

Their work is characterized by a multidisciplinary approach addressing complex biological and metabolic pathways, especially focusing on aging, metabolic regulation, and immune cell function. The breadth and depth of their research themes reflect an ongoing engagement with both fundamental biological mechanisms and applied therapeutic strategies.

Best Publications

  • Resveratrol improves health and survival of mice on a high-calorie diet

    Joseph A. Baur;Kevin J. Pearson;Nathaniel O Price;Hamish A. Jamieson

  • Therapeutic potential of resveratrol: the in vivo evidence.

    Joseph A. Baur;David A. Sinclair

  • SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

    Nathan L. Price;Ana P. Gomes;Alvin J.Y. Ling;Filipe V. Duarte

  • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

    Kevin J. Pearson;Joseph A. Baur;Kaitlyn N. Lewis;Leonid Peshkin

  • Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

    Dudley W. Lamming;Lan Ye;Pekka Katajisto;Marcus D. Goncalves

  • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

    Dohoon Kim;Dohoon Kim;Minh Dang Nguyen;Matthew M. Dobbin;Andre Fischer

  • Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

    Alessia Angelin;Luis Gil-de-Gómez;Satinder Dahiya;Jing Jiao

  • Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

    Hongying Yang;Tianle Yang;Joseph A. Baur;Evelyn Perez

  • Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

    Richard A. Miller;Richard A. Miller;David E. Harrison;C. M. Astle;Joseph A. Baur

  • NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

    Jun Yoshino;Joseph A. Baur;Shin ichiro Imai;Shin ichiro Imai

  • Resveratrol and health – A comprehensive review of human clinical trials

    James M. Smoliga;Joseph A. Baur;Heather A. Hausenblas

  • Functional requirement of p23 and Hsp90 in telomerase complexes

    Shawn E. Holt;Shawn E. Holt;Dara L. Aisner;Joseph Baur;Valerie M. Tesmer

  • Telomere Position Effect in Human Cells

    Joseph A. Baur;Ying Zou;Jerry W. Shay;Woodring E. Wright

  • A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

    Cholsoon Jang;Sungwhan F Oh;Shogo Wada;Glenn C Rowe

  • Rapalogs and mTOR inhibitors as anti-aging therapeutics.

    Dudley W. Lamming;Lan Ye;David M. Sabatini;Joseph A. Baur

  • What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

    Ole Vang;Nihal Ahmad;Clifton A. Baile;Joseph A. Baur

  • Are sirtuins viable targets for improving healthspan and lifespan

    Joseph A. Baur;Zoltan Ungvari;Robin K. Minor;David G. Le Couteur

  • Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

    Ling Liu;Ling Liu;Xiaoyang Su;Xiaoyang Su;William J. Quinn;Sheng Hui

  • Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

    Ki Wung Chung;Poonam Dhillon;Shizheng Huang;Xin Sheng

  • SRT1720 improves survival and healthspan of obese mice

    Robin K. Minor;Joseph A. Baur;Ana P. Gomes;Theresa M. Ward

Frequent Co-Authors

David A. Sinclair
David A. Sinclair Harvard University
Joshua D. Rabinowitz
Joshua D. Rabinowitz Princeton University
Rafael de Cabo
Rafael de Cabo National Institutes of Health
Dudley W. Lamming
Dudley W. Lamming University of Wisconsin–Madison
Anna Csiszar
Anna Csiszar University of Oklahoma Health Sciences Center
Zoltan Ungvari
Zoltan Ungvari University of Oklahoma Health Sciences Center
Woodring E. Wright
Woodring E. Wright The University of Texas Southwestern Medical Center
Jerry W. Shay
Jerry W. Shay The University of Texas Southwestern Medical Center
David E. Harrison
David E. Harrison Jackson Laboratory
Kevin G. Becker
Kevin G. Becker National Institutes of Health

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